Author: Kristy Licari

July 1, 2015 – Ithaca, NY – As previously mentioned in the June 5, 2015 announcement of the signing of the Merger Agreement, effective July 1, 2015, Beijing Bohui Innovation Technology, Ltd. completed the acquisition of Advion, Inc.

About Advion, Inc.
Advion develops, manufactures and globally supports mass spectrometers, chip-based ion sources, microfluidic flow chemistry systems and consumables for life science and related industries. We seek to enhance analysis performance and workflows. Using our deep scientific and engineering knowledge of mass spectrometry and microfluidics, we leverage our passionate employees’ commitment to create quality, flexible and fit-for-purpose solutions. More about Advion, Inc. can be found on our website, www.advion.com.

About Bohui
Bohui Innovation Technology Co. is a developer, manufacturer, supplier and service provider of diagnostic systems related to women and children’s health.  Its core product line is fully automated blood heavy metal analyzers.  It is committed to developing microfluidic and mass spectrometry technologies for diagnostic and inspection applications.  Bohui is located in Beijing and publically traded in the Chinese stock market.  More about Bohui can be found on our website, www.bohui-tech.com.

For Advion, Inc.
Amy Lummus
Director of Marketing
Advion, Inc.
Telephone: 1.607.379.4565
alummus@advion.com

For Bohui
Min Liu
Secretary of the Board
Bohui Innovation Technology Co.
Telephone: 010 8885 0168
Email: liumin@bohui-tech.com

June 5, 2015 – Ithaca, NY – Advion, Inc., a leading systems and consumables developer for the life sciences industry, announces it has signed a definitive agreement to be acquired by Bohui with an expected close date on June 30, 2015. The acquisition is strategic for both companies and will enable Advion to broaden its investments in the areas of life science, clinical, and food safety applications. Advion will continue to trade under its current name and brand, with all employees and executives remaining with the company. All three (3) operations and locations in Ithaca, NY are expected to remain unchanged into the future.

Commenting upon the acquisition, Advion’s CEO Dave Patteson stated “Our company’s business progression has been quite notable over the past three years since we launched the expression CMS line of compact mass spectrometers. Following substantial inbound interest to acquire Advion, we utilized an investment banking partner to conduct a formal process. Our strategic alignment with Bohui is remarkable. Their commitment to the development of clinical applications of MS technology, and substantial footprint in the world’s fastest growing economy have created an ideal combination.”

Bohui’s CEO, Lu Xinqun continued, “We have been impressed by Advion’s deep technical skills and operational excellence. Bohui intends to fully fund Advion’s R&D projects to strengthen its market position, and to promote Advion’s products in the Chinese Market. Advion’s strong presence in North America and the EU also allow for Bohui to gain a more balanced global footprint. Advion’s academic and life science focus is a perfect pairing with Bohui’s traditional markets and clinical presence.”

About Advion, Inc.

Advion develops, manufactures and globally supports mass spectrometers, chip-based ion sources, microfluidic flow chemistry systems and consumables for life science and related industries. We seek to enhance analysis performance and workflows. Using our deep scientific and engineering knowledge of mass spectrometry and microfluidics, we leverage our passionate employees’ commitment to create quality, flexible and fit-for-purpose solutions. More about Advion, Inc. can be found on our website, www.advion.com.

About Bohui

Bohui Innovation Technology Co. is a developer, manufacturer, supplier and service provider of diagnostic systems related to women and children’s health. Its core product line is fully automated blood heavy metal analyzers. It is committed to developing microfluidic and mass spectrometry technologies for diagnostic and inspection applications. Bohui is located in Beijing and publically traded in the Chinese stock market. More about Bohui can be found on our website, www.bohui-tech.com.

For Advion, Inc.

Amy Lummus
Director of Marketing
Advion, Inc.
Telephone: 1.607.379.4565
alummus@advion.com

For Bohui

Min Liu
Secretary of the Board
Bohui Innovation Technology Co.
Telephone: 010 8885 0168
liumin@bohui-tech.com

June 1, 2015 – Ithaca, NY – Advion, Inc., a leading systems and consumables developer for the life sciences industry, has launched the the expression^E compact mass spectrometer (CMS).  Created specifically for global education institutions interested in providing industry-relevant, hands-on mass spectrometry experience at an affordable price point, the expression^E delivers tailored performance, versatile sample introduction systems, and a clear, easy-to-follow, complete curriculum with a lecture and video series created by Jack Henion, PhD, an expert in mass spectrometry and co-inventor of the modern ion-spray technique.

The United States is home to more than 600 undergraduate chemistry programs recognized by the American Chemical Society (ACS), and many are small private institutions, creating challenging funding environments for expensive analytical equipment. Advion has not only priced the expression^E at an affordable price, but also created an academic teaching “kit” including the most desirable chemistry, biochemistry or medicinal chemistry program features: a single quadrupole mass spectrometer, computer, training, choice of interfaces, and an easy-to-follow video and lecture curriculum.

The expression^E offers unrivaled student and faculty flexibility and versatility, enabling users to learn various sample introduction techniques including manual injection and liquid chromatography (LC). Unique to the CMS is the direct analysis probe (ASAP®), whereby students simply dip the probe into their reaction mixture and insert the probe into the mass spectrometer for immediate analysis without additional sample preparation. Or by using the Plate Express TLC/CMS interface, students can analyze a developed TLC plate without the need for scraping spots.

“Advion strives to deliver instruments specific to the chemist’s needs and we have long been aware of the need for a robust, simple mass spectrometer in chemistry teaching laboratories. The expression^E and course curriculum were created with input from a number of academic users who have a need for both the lab-based assays and the lecture course”, comments Simon Prosser, Vice President of Marketing. “We see the ability to provide hands-on, industry relevant training with mass spectrometers capable of directly analyzing liquid samples as a huge benefit to any undergraduate or graduate degree program.”

Attendees at the American Society for Mass Spectrometry (ASMS) Annual Meeting in Saint Louis, MO will have the opportunity to get a glimpse of the slide presentation and videos at Advion’s booth number 171.

Learn more.

March 23, 2015 – Ithaca, NY – Advion, Inc., a leading systems and consumables developer for the life sciences industry, introduces the Plate Express^TM, a patent-pending automated software-controlled system to directly analyze thin-layer chromatography (TLC) plates and a full range of other planar surfaces by mass spectrometry.  Plate Express provides a simple, automated, software-clicked means of visually pinpointing and extracting compounds from a range of TLC plate formats into Advion’s expression^® compact mass spectrometer (CMS). The combined technique is known as TLC/CMS. Synthetic organic, natural product and peptide chemists can quickly and confidently identify analytes in complex mixtures without additional sample preparation utilizing TLC/CMS

Plate Express is controlled by Advion’s Mass Express software, vastly simplifying the process and increasing the robustness of TLC spot and planar surface analysis. A patent-pending pressure-sensing feature allows for uncommon force management to be controlled, superbly sealing around the point of interest, while extending the life of the probe, further reducing the cost of consumables. For routine and expert users alike, the software allows for methods to be developed for their plates and surfaces of choice.

“Advion developed the patent-pending Plate Express with input from chemists involved in several research areas as well as extensive review of peer-reviewed publications,” comments Simon J. Prosser, Vice President of Marketing. “We identified a strong market desire for an integrated simple to use, software-enabled technique, not requiring expertise in mass spectrometry, as well as robust enough to handle more challenging mixtures, plate types and other planar surfaces.  Initial feedback has been tremendous.”

The system works by placing a developed TLC plate into the device, aligning the spot of interest and clicking the Mass Express start button, then real-time data is displayed on the computer screen. Plate Express can also be used to extract samples from other surfaces, such as papers and biological tissue samples, with an array of extraction heads available, and each optimized for different applications. With many features designed specifically to extend probe life and auto-clean, the combined TLC/CMS system is ideally suited for chemistry laboratories and QA/QC.

The Plate Express/expression CMS system is on display at the ACS National Spring Meeting 2015 at the Denver Convention Center booth #1033, ANAKON in Gras, Austria at stand B1, and at the 32nd SCI Process Development Symposium in Cambridge, UK. In addition, a presentation about all capabilities of the expression CMS including the new Plate Express will be given during Advion’s exhibitor workshop on Tuesday, March 24th at 9:30 AM in the Denver Convention Center, Room 301. All ACS attendees and Denver locals are welcome to attend.

December 1, 2014 – Ithaca, NY – Advion, Inc. announces that its TriVersa NanoMate with liquid extraction surface analysis (LESA) capability will be evaluated as part of a study at Brigham and Women’s Hospital.

When coupled to a mass spectrometer, the TriVersa NanoMate with LESA capability allows for automated and direct sample analysis from samples with minimal sample preparation. The user can select tissue samples around the interest area, and get real-time mass spectral data.

Dr. Nathalie Agar, Director of the Surgical Molecular Imaging Laboratory in the Department of Neurosurgery at BWH, will work with tissue preparations for biomarker analysis to guide real-time surgical margin decisions in the operating room with a comparison to alternative modern techniques as well as traditional pathology. The purpose of the study is to determine novel markers for cancer tissue, detect them using LESA and mass spectrometry, and then guide precise and accurate surgery marginal incision start and stop points. If successful, this could increase treatment success, decrease residual cancer presence and minimize unnecessary removal of healthy tissue.

According to Advion Chief Scientific Officer, Jack Henion, PhD, “This is an exciting aspect of translational research for cancer biomarkers that potentially has immediate benefit for patients undergoing cancer surgery. In the intended workflow from ‘bench-to-bedside’ (or more accurately from ‘bench-to-operation room’) a surgical decision is guided not only by standard procedures but additionally by mass spectrometry data from tissue samples obtained in real-time during the procedure.”

Pilot experiments are now underway with an initial publication targeted for early 2015.

About Advion, Inc.

Advion develops, manufactures and globally supports mass spectrometers, chip-based ion sources, microfluidic flow chemistry systems and consumables for life science and related industries. We seek to enhance analysis performance and workflows. Using our deep scientific and engineering knowledge of mass spectrometry and microfludics, we leverage our passionate employees’ commitment to create quality, flexible and fit-for-purpose solutions. More about Advion, Inc. can be found on our website, www.advion.com.

For Advion, Inc.

Amy Lummus
Director of Marketing
Advion, Inc.
Telephone: 1.607.379.4565
alummus@advion.com

August 7, 2014 – Ithaca, NY – Advion, Inc., a leading systems and consumables developer for the life sciences industry, introduces an affordable high performance liquid chromatography system to complement its line of expression compact mass spectrometers (CMS).  Introduced in 2012, the CMS has been met with glowing reviews from the global synthetic organic chemistry market. With hundreds of CMS purchased and installed, this latest introduction offers a complete solution for those needing separation capabilities at an affordable price.

Leveraging the 100-240 VAC requirements, the Advion LC/CMS system can become transportable on a cart or installed in space-restricted benches and hoods, allowing for easy access.  With unrivaled ease-of-use, and the ability to utilize the CMS for multi-modalities, Advion’s LC/CMS offers chemists within teaching labs, research facilities and industry a high performance solution at an affordable price.  Moreover, Advion is increasingly the vendor of choice for numerous accounts requiring a full scope of LC, CMS, TLC-CMS, pumps, integration kits and extended support packages.

“LC/MS is an important technique for complex sample analysis, especially final synthetic route steps, registration vial characterization, and publication-quality data, while offering a level of high purification certainty. Our novel solutions will allow the chemists to stay well within their budgets and take control of their assays. This saves time, improves information and workflow” comments David B. Patteson, Chief Executive Office and President. “In addition, integration of the system through the Clarity software program with full quantitation and 21CFR11 compliance makes it a complete LC solution.”

The new LC system will be displayed at next week’s ACS National Fall Meeting 2014 in booth 1007 at the Moscone Convention Center in San Francisco from August 10 – 12. In addition, Advion is hosting an exhibitor workshop on Monday, August 11^th at 9:30 AM in Moscone room 206. All ACS attendees and locals are welcome to attend.

August 6, 2014 – Ithaca, NY – Advion, Inc., a leading systems and consumables developer for the life sciences industry, announces the release of a Direct Analysis Probe for its line of expression compact mass spectrometers (CMS). With hundreds of CMS systems utilized in chemistry laboratories around the world, this latest development creates yet another important tool for chemists who need fast, simple, reliable sample analysis of liquids and solids such as reaction mixtures, food samples, natural products and tablets without the need for sample preparation.

Chemists’ assays are often driven by their need to understand reaction kinetics and composition, to decide when to quench reactions, and verify iterative and final purification fractions. Recognizing the unrivaled flexibility of the Advion CMS as a detector across many workflows, the Direct Analysis Probe delivers essential mass spectral information of compounds in less than one minute.

The new Direct Analysis Probe sample introduction, otherwise known as ASAP® (Atmospheric Solids Analysis Probe), uses a standard glass melting point capillary which is introduced into CMS system.  Chemists dip the closed end of the capillary into the sample of interest (even complex reaction mixtures) or scrape the surface of a solid, and then place the capillary into the CMS for analysis. Involatile contaminants remain on the glass capillary, while compounds of interest are identified by the CMS.

“The holy grail of mass spectrometry is direct mass spectrometric analysis without sample preparation and the Direct Analysis Probe enables this,” comments David B. Patteson, Chief Executive Officer and President. “Customer sites already using the Direct Analysis Probe with the CMS rave about the simplicity and productivity gains and are surprised at the affordability of the system.”

The Direct Analysis Probe sample introduction system on the Advion CMS will be displayed at booth #1007 during next week’s ACS National Fall Meeting 2014 at the Moscone Convention Center in San Francisco from August 10 – 12. In addition, data obtained using the new ion source will be presented during an exhibitor workshop on Monday, August 11^th at 9:30 AM in Moscone room 206. All ACS attendees and locals are welcome to attend.

January 7, 2014 – Ithaca, NY – Advion, Inc., a leading systems and consumables developer for the life sciences industry, announced today the release of the latest development in its line of compact mass spectrometers, the expression S. This latest release includes benefits that further address the needs of Advion’s key target market of academic, industry and research chemistry groups.  The new enhancements include polarity switching during a single analysis to ensure detection of the greatest range of compounds, fast mass scanning (10,000 u/s) for compatibility with UPLC, SFC and where multiple compounds need to be monitored simultaneously with SIM, as well as higher flow rates of 1-2 ml/min for simpler interfacing with standard chromatographic conditions.

The expression S, along with the recently released expression L for large molecule applications, replaces the first generation expression CMS, which will remain available for Advion’s OEM partners on an indefinite basis. The two new CMS units allow Advion to offer enhanced performance specifications to address specific workflow challenges.

In addition to the hardware enhancements, a large number of new software features are being released with the new CMS models to offer additional analysis and data processing options and further improve ease of use. The new software also provides compatibility with DataApex Clarity chromatography software providing seamless integrations with many LC platforms.

“Advion developed the expression line of compact mass spectrometers to address the very specific needs of chemists. As we have learned more from our customers, we recognized the unique needs of our users,” comments Simon Prosser, Vice President of Marketing. “We have brought to the chemist’s bench the best-in-class mass spectrometer performance that was previously reserved for mass spec specialists.  By offering an –S and an –L model, chemists have a choice regarding the best fit for their specific application.”

The expression S is available now for orders with a 12 week lead time.  Advion will be holding a press conference during Pittcon in Chicago, IL on Tuesday, March 4th at 1:00 P.M.

About Advion, Inc.

Advion develops, manufactures and globally supports mass spectrometers, chip-based ion sources, microfluidic flow chemistry systems and consumables for life science and related industries. We seek to enhance analysis performance and workflows. Using our deep scientific and engineering knowledge of mass spectrometry and microfludics, we leverage our passionate employees’ commitment to create quality, flexible and fit-for-purpose solutions. More about Advion, Inc. can be found on our website, www.advion.com.

For Advion, Inc.
Amy Lummus
Director of Marketing
Advion, Inc.
Telephone: 1.607.379.4565
alummus@advion.com

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December 9th, 2013 – Ithaca, NY – Advion, Inc., a leading instruments and consumables developer for the life sciences industry, announced today the release of the latest in chip-based technology, the Chip-Mate™. The Chip-Mate is an ESI Chip®-based nano-LC ion source for applications requiring small micron ID HPLC columns and nanoelectrospray ionization (nano-ESI). This latest product offering from Advion is a line extension of its well-established TriVersa NanoMate® technology.

While the TriVersa NanoMate has multiple modes of operation, the Chip-Mate is an easy-to use nano-LC ion source that focuses on stable and reliable nano-ESI through its ability to sense poor spray performance and engage the next nozzle. Ease-of-use and robustness of nano-ESI are important features for proteomics customers as well as applications in highly regulated environments such as biomarker/biosimilar and small molecule quantification utilizing nano-LC.

For use with the Chip-Mate, Advion has created a smaller footprint ESI Chip with 25 emitter nozzles and an integrated memory card. In combination with spray sensing and next nozzle capability, researchers can now have complete confidence for 24/7 nano-LC/MS/MS operation.

“Advion is known for its fit-for-purpose products and creating instrumentation that eases challenging workflows. This latest development offers the established benefits seen with chip-based nanoelectrospray in a package just for nano-LC users,” notes Simon Prosser, Vice President of Marketing. “We have long anticipated this product introduction, and given the advancements in nano-LC and proteomics, we believe this is the optimal time to offer this product to the market.”

Compatible with Thermo Fisher model mass spectrometers, including the LTQ, Orbitrap, Fusion, Exactive TSQ, etc., the Chip-Mate is now available for shipment with first units shipping this month to customers in Europe, the US and South America. Chip-Mate is available worldwide through a global network of distributors committed to innovative technology and exceptional customer service.

About Advion, Inc.
Advion develops, manufactures and globally supports mass spectrometers, chip-based ion sources, microfluidic flow chemistry systems and consumables for life science and related industries. We seek to enhance analysis performance and workflows. Using our deep scientific and engineering knowledge of mass spectrometry and microfludics, we leverage our passionate employees’ commitment to create quality, flexible and fit-for-purpose solutions. More about Advion, Inc. can be found on our website, www.advion.com.

For Advion, Inc.
Amy Lummus
Director of Marketing
Advion, Inc.
Telephone: 1.607.379.4565
alummus@advion.com