Mass Spec Solutions for Chemical Biology

Advion is the partner of choice for biopharmaceutical, academic/government researchers, and industrial chemists seeking to enhance their chemical synthesis knowledge, workflow and mass spectrometry results. Using our deep scientific and engineering expertise, we develop a broad portfolio of chemist-centric, purpose-built mass spectrometers, nanoelectrospray ionization sources, flow-chemistry synthesis systems and consumables characterized by their reliability, high quality and flexibility.

Advion has added highperformance, dependable and easy to use HPLC and
UHPLC systems with best-in-class performance into our lineup of sample introduction systems. Modular, stackable design provides configurations from
the simplest, least expensive, manual injection HPLC to a fully streamlined UHPLC system and everything inbetween.

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Introducing a new type of mass spectrum, available exclusively in the Advion peak Express software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance.

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The inert ASAP (iASAP) allows easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove box or Schlenk line to prevent oxidation. The technique allows a synthetic chemist to perform real-time reaction monitoring.

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The vAPCI ion source for the expression CMS is a simple, powerful tool for gas phase sample analysis. The technique can quickly and confidently identify compounds in air, breath, headspace and other gas samples without the need for any sample preparation.

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Quant Express, an addition to Advion’s user-friendly Mass Express 4.0 software suite, features quantitation to create a fully integrated software system for expression CMS users.

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The Chemist’s Detector

A high performance mass spec for every chemistry laboratory

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Chip-based electrospray ionization technology

Combining the strengths of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated system

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Featured Applications

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Natural products

Faster scan speed, online polarity switching and in-source CID to generate the information for compound identification and structural information of previously unknown natural product analytes.

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Reaction monitoring

The expression CMS addresses the need of organic and synthetic chemists to understand the optimal time to quench a reaction mixture. They can obtain answers within minutes rather than hours or days.

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Teaching chemistry

Advion offers a plug and play, compact, single quadrupole mass spectrometer designed specifically with the academic chemistry laboratory in mind, the expressionE CMS.

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Protein assays and peptide synthesis

Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions in the modern laboratory.

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Success Stories

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New Path Molecular Ltd, United Kingdom

“Expression CMS meets our requirements for an instrument that is intuitive to use, robust and capable of being maintained, expanded and serviced without manufacturer call outs.”

Dr. Gary Tarver, Lead Chemist

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University of Cambridge, Ley Group

“I would recommend the system to any group that works with continuous flow chemistry, especially those that need real time analysis of stream compositions.”

Daniel E. Fitzpatrick, Ph. D Candidate, Student Researcher & Founder, ChemInventory

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Research Analyst – University of Leiden

“I incorporated the expression CMS as a TLC/MS system because of its simplicity, low cost and the brilliant combination with the Plate Express.”

Dr. Hans van den Elst, Research Analyst, University of Leiden

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Department of Chemistry – Creighton University

“It’s easy, walk-up use with straightforward swapping of ESI and APCI sources make it a reliable, productive tool for determining synthetic success.”

Dr. Martin Hulce, Department of Chemistry, Creighton University

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December 5 - 7

Gulf Coast Conference

January 17 - 18
Houston, TX

MSACL – Mass Spectrometry Applications to the Clinical Lab 2017

January 21 - 25
Palm Springs, CA

27th Applied Technical Chemistry (ATC) – Conference 2018: Industrial Inorganic Chemistry – Materials and Processes

February 22 - 23
Frankfurt am Main, Germany

Press Releases

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