The Advion Interchim Scientific suite of systems and consumables allows users to harness the power of mass spectrometry, flash chromatography, prep LC and more. Simple and robust, download our brochure to learn more about:
The Advion Interchim Scientific expression® compact mass spectrometer (CMS): A fast and easy analytical tool for the organic chemist. Ideal for fast reaction monitoring, the expression® CMS features a single quadrupole that can adapt to multiple ionization sources in seconds, including both ESI and APCI. The expression® CMS offers a variety of novel sampling techniques, including fast assay methods for liquids, solids, gases, and even air-sensitive compounds.
Direct mass analysis of TLC plates in 30 seconds at the push of a button with Plate Express™
One-touch analysis of solids and liquid samples with the ASAP® probe
LC/CMS
puriFlash® ultra performance flash purification: Ideal for method development and purification of rare and high added value compounds, the Interchim family of puriFlash® systems offer users a wide range of throughput options and the highest recovery rates at >95%.
Mass-Guided Purification: the Interchim puriFlash® + Advion CMS offers the ideal solution for Flash-MS, and can provide fraction identification in <30 seconds.
Fill out the form to download the full Advion Interchim Scientific brochure now.
Martin-Luther-University Halle-Wittenberg, Free University of Berlin
Abstract
Cannabis products have been used in various fields of everyday life for many centuries, and applications in folk medicine and textile production have been well-known for many centuries. For traditional textile production, hemp fibers were extracted from the stems by water retting in stagnant or slow-moving waters.
During this procedure, parts of the plant material‚ among them phytocannabinoids‚ are released into the water. Cannabinol (CBN) is an important degradation product of the predominant phytocannabinoids found in Cannabis species. Thus, it is an excellent indicator for present as well as ancient hemp water retting.
In this study, we developed and validated a simple and fast method for the determination of CBN in sediment samples using high-performance thin-layer chromatography (HPTLC) combined with electrospray ionization mass spectrometry (ESI-MS), thereby testing different extraction and cleanup procedures‚ as well as various sorbents and solvents for planar chromatography.
This method shows a satisfactory overall analytical performance with an average recovery rate of 73%. Our protocol enabled qualitative and quantitative analyses of CBN in samples of a bottom sediment core‚ having been obtained from a small lake in Northern India, where intense local retting of hemp was suggested in the past. The findings correlate with existing records of Cannabis-type pollen. Thus, the method we propose is a helpful tool to track ancient hemp retting activities.
The Advion TLC/CMS system with the expression® Compact Mass Spectrometer (CMS) and Plate Express® TLC Plate Reader was utilized for the elution of compounds from the HPTLC plates.
In this Lab Manager webinar, Dr. Daniel Eikel, Advion Director of Product Applications and Customer Service reviews the use of the Advion expression Compact Mass Spectrometer (CMS) for food and beverage analysis.
As an attendee, you will learn more about:
How leading technologies and techniques affect food science researchers
How to establish workflows that optimize the efficiency of your food science lab
New and novel applications in the field of food and beverage science
Constructive machine learning aims to create examples from its learned domain which are likely to exhibit similar properties. Here, a recurrent neural network was trained with the chemical structures of known cell‐migration modulators. This machine learning model was used to generate new molecules that mimic the training compounds. Two top‐scoring designs were synthesized, and tested for functional activity in a phenotypic spheroid cell migration assay. These computationally generated small molecules significantly increased the migration of medulloblastoma cells. The results further corroborate the applicability of constructive machine learning to the de novo design of druglike molecules with desired properties.
Analysis was performed by TLC/MS using the Advion expression Compact Mass Spectrometer (CMS) and Plate Express TLC Plate Reader.
Leiden University, Eindhoven University of Technology
Abstract
The structure of the copper complex of the 6-((1-butanethiol)oxy)-tris(2-pyridylmethyl)amine ligand (Cu-tmpa-O(CH2)4SH) anchored to a gold surface has been investigated. To enable covalent attachment of the complex to the gold surface, a heteromolecular self-assembled monolayer (SAM) of butanethiol and a thiol-substituted tmpa ligand was used…These results show that upon immobilization of Cu-tmpa-O(CH2)4SH, the resulting structure is not identical to the homogeneous CuII-tmpa complex. Upon anchoring, a novel CuI species is formed instead. This illustrates the importance of a thorough characterization of heterogenized molecular systems before drawing any conclusions regarding the structure–function relationships.
The cannabinoid makeup of cannabis has significantly changed over the past few decades. Efforts to increase the psychotropic effects of cannabis have resulted in a THC content for current strains of the crop of 30 to 40 percent compared with only 5 percent 30 years ago. Up-regulating the THC content of the plant causes a loss of other cannabinoids the plant is producing. Some of these other cannabinoids, such as CBD, are believed to be responsible for its medical benefits.
Furthermore, no pesticides can currently legally be used during the production process. However, a recent test showed that two out of three samples of legal cannabis samples had pesticide residues above the legal limit for an edible. Once sample exceeded the limit by a factor of 1,600. Such a sample poses a consumer health risk and clearly shows the potential for illegal growing procedures or unclear product streams in the marketplace.
Additionally, cannabis contains more than 400 chemical compounds, 80 of which are unique to cannabis. This fact, plus the finding of cannabinoid receptors in human nerve, immune and brain cells explains why this product is such an interesting target for medicinal use.
This webinar examines three different workflows surrounding compact mass spectrometry as they apply to cannabis law enforcement, it’s natural product research, and product control.
Thanks to the diminishing size and cost of mass spectrometers, coupled with their increasing robustness and ease of use, universities are now starting to furnish their undergraduate chemistry laboratories with this advanced analytic tool.
“My favorite learning environment is the laboratory,” explains Paul A. Flowers, professor of analytical chemistry at University of North Carolina at Pembroke. “I like teaching students fundamentals through bona fide research experiences.” Flowers began using mass spectrometry in the teaching laboratory about six years ago and hasn’t looked back.
Learn more about the integration of mass spectrometry for teaching with this free whitepaper.
Advion Interchim Scientific’s Plate Express® is ideal for fast, easy TLC/MS analysis. Coupled with the expression® Compact Mass Spectrometer (CMS), the TLC plate reader allows prep-free sampling and data in less than 30 seconds.
Nigerian Institute for Trypanosomiasis, University of Jos, University of Yaoundé
Abstract
Medicinal plants are the richest bio-resource of drugs for traditional systems of medicine, modern medicines, food supplements, pharmaceutical intermediates and chemical entities for synthetic drugs. Human African Trypanosomiasis (HAT) is a challenging and deadly disease due to its complex epidemiology and clinical presentations. This study was conducted to investigate anti-trypanosomal action of Ximenia americana root bark on Trypanosoma brucei brucei using various solvent extracts and to develop thin layer (TLC-MS) and liquid chromatography-mass spectrometric (LC-MS) profiles of the plant. Soxhlet extraction was used to obtain acetone, 70% ethanol total extracts in addition to n-hexane, dichloromethane, ethyl acetate and methanol fractions by sequential extraction. The inhibitory activity of the various extracts was compared by testing against T. b. brucei using isometamidium chloride as standard drug. The most active extract was separated by solid-phase extraction (C18 stationary phase) to obtain fractions which were profiled by TLC-MS (+ESI) and LC-MS. It was observed that anti-trypanosomal activity of acetone (16.83% yield) and 70% ethanol (18.23% yield) were comparable. However, methanol extract exhibited the highest activity with 99.18%, 97.5% and 87.50% inhibition at 3 h incubation (room temperature) using 1000 µg, 500 µg and 250 µg concentrations respectively. The activities at 1000 µg for methanol extract and isometamidium chloride were comparable with 95% CI [-1.10, 1.77]. TLC-MS and LC-MS analyses suggested gallic acid, 2,3,4,5-tetrahydroxybenzoic acid, 2ʹ,5-dimethoxyflavone, quercetin, dihydroquercetin and sesquiterpene when compared with literature database. This study presents data that could be useful in standardisation and preparation of alternative medicine in the treatment of African trypanosomiasis.
Analysis was performed by TLC/MS using the Advion expression Compact Mass Spectrometer (CMS) and Plate Express TLC Plate Reader.
Reaction monitoring is a key aspect in a range of chemistry environments from chemical synthesis to drug discovery to understanding natural products to protein synthesis. Understanding the optimal time to quench a reaction for maximum yield, as well as monitoring a reaction in real-time is vital to many medicinal and synthetic organic chemists. Advion Interchim Scientific’s expression® CMS was developed with the chemist in mind to optimize their workflow directly at the bench. It is an easy-to-use and maintain single quadrupole detector that integrates with the industry’s broadest range of innovative sampling techniques from direct probe analysis to ultra-high performance liquid chromatography. Users can rapidly switch between the many different sampling techniques required throughout the chemist’s workflow.
