Q: What is the focus of your lab’s research?
A: Medicinal chemistry research in my lab is a collaborative exercise where we engage other scientists with complementary interests. Currently, we are engaged in the discovery of protein kinase inhibitors for anti-infective and anti-inflammatory applications and in the discovery of new agents useful for the potential treatment of neurodegenerative diseases. We are working with others at MSU as well as scientists in other universities and research institutes.
Q: Why did you incorporate the expression CMS into your laboratory?
A: As a medicinal chemist working in the industry, I wanted to have access to the same technology for my group’s research at MSU. However, working in the industry I had experts to run samples. In my lab at MSU, it is essential to have the same technology available in an easy to use the instrument. Not only do the expression CMS specifications meet our needs perfectly, but also it runs without a hitch and it is easily serviceable by a non-expert.
Q: Who would you recommend to purchase the expression CMS?
A: I would recommend the expression CMS to any non-expert chemist or laboratory who needs access to this level of technology. The Advion service and support groups make it accessible.
The expression compact mass spectrometer (CMS) is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.
The rapid identification of radiolabeled compounds would clearly be beneficial for applied clinical and preclinical tracers used for imaging with positron emission tomography (PET). The limited uptake of mass spectrometry in the imaging field has been due to several factors including concerns regarding adequate sensitivity, instrument footprint in the highly constrained space requirements for the majority of labs and high initial capital costs plus high ongoing maintenance costs.
The introduction of the expression Compact Mass Spectrometer (CMS) at the 2012 Spring ACS National Meeting addressed for the first time three of the concerns: space, capital cost and maintenance costs. Only the question of adequate sensitivity remained to be answered.
Ultra (high) performance liquid chromatography (UPLC/UHPLC) is a relatively new technique, and is valued for its speed, efficiency and the quality of information provided. Many synthetic and medicinal chemistry laboratories are moving to this process to improve their workflows and save time.
Q: What is the focus of youR lab’s ReseaRch?
A: Our activities on lignin chemistry cover the extraction of lignin by the organosolv process, characterization of lignin and development of catalysts for lignin hydrogenolysis, oxidation and depolymerization.
The similarity between the chemical structures of low ranking coals and lignin encourages us to develop integrated strategies to process coal and biomass together. Our activities on coal chemistry cover the direct coliquefaction of low ranking coals and biomass to produce liquid fuels.
Furthermore, we are aiming at understanding the process of dissolution of cellulose in nonconventional solvent systems and are exploring the reactivity of cellulose in new solvent systems.
Q: What pRevious WoRkfloW challenges DiD you expeRience?
A: Many scientists generating a high number of diverse compounds need fast and direct access to the exact mass data for those compounds. Thus, we had to find a way to conduct most of the mass determination directly in our laboratory in a timely and cost-efficient way.
Q: Why DiD you incoRpoRate the expRession cMs into youR laboRatoRy?
A: The purchase of Advion expression compact mass spectrometer reveals to be an excellent investment. We are performing analyses of complex samples (e.g., lignin, cellulose and coal products) in a multi-user environment. As such, the Advion device is very easy to operate as well as a robust and very reliable mass spectrometer, surpassing all the expectations that we had for an affordable device.
The expression CMS was developed with the chemist’s objectives and laboratory workflow in mind. Organic, Natural Product and Peptide chemists utilize many techniques to determine the progress, yield and purity of their reactions.
Goa College of Pharmacy
Abstract
The present study was undertaken to carry out phytochemical investigation of the ethanolic extract of the stem bark of Terminalia tomentosa Roxb (ex DC) Wight & Arnbelonging to the family Combreteaceae. The plant is known in Sanskrit as Asana, in English as Black murdah, in Hindi as Asan, Saj, Sain and in Marathi as Ain.The plant has been known to possess various pharmacological activities like antifungal, antioxidant, antihyperglycaemic, antidiarrhoeal, antileucorrheal etc. The bark of the plant is astringent& useful in ulcers, vata, fractures, haemorrhages, bronchitis, diarrhoea etc.Preliminary phytochemical screening of the ethanolic extract of stem bark revealed the presence of carbohydrates, flavonoids, triterpenoids,steroids, tannins and saponins. The chemical entities isolated and characterised includes 4 – methy l – 4 – hydroxymethylene – 6β – (10 – methyl octanyl) cyclohexane (Arjuna homoses quiterpenol), di-n-octyl phthalate, di isobutyl phthalate and dibutyl phthalate. All these phytoconstituents are reported for the first time from the ethanolic extract of stem bark of T.tomentosa.
Mass spectra was obtained by ESI ionization using the Advion expression Compact Mass Spectrometer (CMS).
A novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions.
Medical chemists are routinely faced with personally over a hundred new chemical entities (NCE’s) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route.
Advion demonstrates a novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions employing either LC/MS or flow injection analysis (FIA).
