Recorded May 5, 2022.
Join Daniel Kim, Ph.D., Assistant Professor Organic, Inorganic, Biological, from Temple University, as he presents several new methodologies developed for reaction discovery.
In this webinar, you will learn:
Lab Manager Ask the Expert Webinar. Recorded September 7, 2022
Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how to avoid them to improve your process.
As a viewer, you will learn more about:
Webinar speakers include:
Gary Williams
Vice President, Chemist & North American Sales
Advion Interchim Scientific
Nathaniel Kunzer
Product Specialist
Heidolph
Recorded June 15, 2022.
Join Christopher Thomson, Researcher at Heriot-Watt University, as he shares his work expanding the tool kit of automated flow synthesis with the development of in-line flash chromatography purification.
In this webinar, you will learn:
Chris completed his chemistry with biochemistry degree (MChem, 1st Class) at Heriot-Watt University, Edinburgh, in 2018 and was recipient of the ‘William H. Perkin Prize’ for excellence in organic chemistry. He was then awarded a PhD scholarship through the EPSRC funded centre for doctoral training in critical resource catalysis (CRITICAT), under the joint supervision of Dr Filipe Vilela and Dr Ai-Lan Lee.
Chris’ research focuses on the development and implementation of enabling technologies – especially flow chemistry – to enhance heterogeneous photocatalysis for organic synthesis.
He has published several papers on the development of flow systems featuring enabling technologies, such as: in-line NMR spectroscopy, in-line UV-Vis. spectroscopy, static mixing photocatalyst monoliths produced via functional material additive manufacturing, and most recently, reported the first example of continuous in-line flash chromatography – which will be the subject of this webinar.
In this application note, we describe a novel method to perform the continuous isolation of flow synthesis products from residual starting materials, catalysts or by-products to expedite chemical discovery. A promising new approach is highlighted here, featuring the Advion Interchim Scientific puriFlash® 5.250 preparative LC system.
The first results of our cooperation with the VilelaLAB and Continuum Flow Lab at Heriot-Watt University, Edinburgh, on this topic are outlined here and can be read in more detail in the following source: C.G.Thomson et al.: Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification, J. Org. Chem. 2021, 86, 20, 14079–14094.
Avoid workflow bottlenecks by streamlining the flash purification process in your lab. This whitepaper can help you identify, reduce, or even eliminate these bottlenecks, tanking your standard operational time from hours to minutes. Learn how essential tools including TLC, a smartphone application and a simple dipping probe for fraction ID offer a novel, systematic approach to help accelerate both synthesis and purification.
The NEW puriFlash® XS-Vap, your intuitive laboratory evaporator. X-tra compact. X-tra intuitive. X-tra efficient. X-tra evaporation.
Reduce evaporation time and gas consumption with the most advanced evaporator on the market. The puriFlash® XS-Vap offers an extensive range of benefits over the competition:
In this application note, we used the Advion Interchim Scientific puriFlash® 5.250 to purify five active ingredients found in over-the-counter (OTC) and prescription drugs including caffeine, glafenine, ketoprofen, flavone, and fenofibrate, by a preparative purification workflow. The compounds were then confirmed using the expression® compact mass spectrometer.
The compound synthesis, purification, and confirmation processes often present challenges. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy workflow can be time consuming and repetitive. This webinar will provide a foundation for flash purification processes and will showcase a novel workflow concept that breaks down the process into easy steps for optimal success. We will offer tips to optimize each essential segment of the workflow, and share seamless steps to quickly and easily drive the process from reaction monitoring to flash purification and fraction ID.
Presented by Chase Needham, Application Scientist—Flash and Prep LC
Advion Interchim Scientific. This webinar was hosted by Lab Manager and recorded 9/30/21.
Flash chromatography has traditionally used UV absorption as the main method of detection for compounds during a purification process. While UV absorption is broadly applicable to many classes of compounds, it has limited specificity to individual compounds in a mixture and misses classes of compounds that do not carry chromophores.
Mass-directed fraction collection gives users the ability to collect fractions based on mass spectrometry detection (MS) which is based on ions specific to individual compounds and provides specific molecular information. This allows for simplification in the overall purification process and greater confidence in the identity of each isolated compound. Here we describe methods of isolating natural products from green tea and turmeric powder by mass-directed fraction collection during flash chromatography and preparative LC.
This poster was presented at the 2021 ASMS national conference in Philadelphia, PA.
In this exclusive webinar, our cannabis instrumentation experts will share information about solutions that relieve the purification bottleneck for processors.
This 15-minute on-demand session will cover: