This whitepaper outlines an integrated and streamlined workflow for early-stage drug discovery, covering all key elements of drug development, including compound synthesis, reaction monitoring, purification, compound identification, and evaporation. By leveraging a seamless, end-to-end platform, pharmaceutical companies can accelerate lead optimization, reduce costs, and improve decision-making in the discovery process.
Higher purity. Higher Yield. Optimize your purification workflow, from lab scale to scale-up.
This Webinar was originally presented November 9, 2023 on LabRoots.com
ABSTRACT
In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover:
- How to select the ideal purification solution for your lab’s specific needs
- How to optimize your purification workflow daily, to automate compound ID and fraction confirmation – using simple, prep free tools
- How your cell phone can be used for automated method development
- How column selection factors in to your workflow, and why exploring what is best for your method matters
SPEAKER
Chase Needham, puriFlash and PrepLC Applications Scientist, Advion Interchim Scientific®
Direct, multielement determinations from cotton swipes via Plate Express™ microextraction coupled to an inductively coupled plasma mass spectrometer, SOLATION® ICP-MS
Cameron J. Stouffer and R. Kenneth Marcus *
Abstract
Cloth swipes are a fairly common sampling modality, having relevance across a wide variety of applications including environmental analysis, forensics, and bioassays. One of the biggest attractions of swipes (and related paper substrates) is the ease of sample collection and transportation, where just the swipe of a surface is required to collect particulates or solution phase species, with the substrate then readily transported to laboratory facilities. Additionally, the possibility to sample low-volume analytes, such as blood, gunshot residue, etc., provides additional benefits. The modes for the analytical sampling of the immobilized material vary greatly based on the means of analysis. These vary from direct solid analysis by a variety of optical probing methods, to solvent rinsing/extraction, and complete ashing/digestion of the cloth to liberate adsorbed species. Of the methods applied for elemental (metals) analysis of swipe materials, inductively coupled plasma-mass spectrometry (ICP-MS) is the most versatile in terms of coverage and sensitivity. Recently, a direct microextraction approach has been described for uranium isotope ratio determinations. Here, we describe the initial methodology development towards the use of the Advion Interchim Scientific® Plate Express™ microextraction device, coupled to an Advion Interchim Scientific® SOLATION® ICP-MS, for simultaneous, multielement analysis. Practical means of identifying test sites and evaluating elution quality are described. Methods of multielement quantification are identified with preliminary figures of merit presented. Finally, use of the method to quantify metals spiked into a synthetic urine matrix is demonstrated. While areas of improvement are clearly suggested, this rapid (<2 min) method of direct microextraction into the ICP (Ex-ICP-MS) shows great promise for use across diverse applications.
Advion Interchim Scientific® SOLATION® ICP-MS and Plate Express™ (Advion, Ithaca, NY) was utilized.
A Handheld Guide: Fun & Easy Mass Spectrometry Experiments for your Teaching Lab
A book of experiments for your students
The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.
Rapid Analysis Using Direct Microextraction Assays Coupled to the New SOLATION® ICP-MS
Recorded February 2, 2023: LIVE Location, the 2023 European Winter Conference on Plasma Spectrochemistry
Speakers:
Janez Ilaš, Ph. D., Professor, University of Ljubljana
Fadi Abou-Shakra, Director of Advion Interchim Scientific® ICP-MS Portfolio
Join Advion Interchim Scientific® with guest speaker from the University of Ljubljana, Faculty of Pharmacy, to learn more about a new novel sample introduction method for ICP-MS utilizing direct analysis via microextraction. First you will learn microextraction methods with the Plate Express TLC Plate/microextraction reader coupled to the single-quadrupole expression® Compact Mass Spectrometer (CMS). After understanding the basics of the platform, you will learn more about how this technology was reimagined to suit the SOLATION® ICP-MS for a rapid method to determine isotopic analysis faster and easier than ever before.
Ready to learn more?
Extraction and Purification of 3 Curcuminoids from Turmeric Powder
In this application note, a method to separate and purify 3 curcuminoids from turmeric powder using thin layer chromatography (TLC) with mass spectrometry and flash chromatography is demonstrated.
Mass Spectrometry for Teaching Chemistry Undergraduates – The expression® CMS & the SOLATION® ICP-MS
Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium
Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications.
Fadi Abou-shakra started using ICP-MS in 1987 applying it for the analysis of trace elements in biological fluids and has been active in the field of atomic spectroscopy since then. He holds an MSc in Medical Physics and a PhD in Chemistry from the University of Surrey, England. He brings a wealth of experience in ICP-MS as a researcher, customer support specialist and a business manager.
Ready to learn more?
Development of New Synthetic Methodologies Enabled by Advion Interchim Scientific Workflow
Recorded May 5, 2022.
Join Daniel Kim, Ph.D., Assistant Professor Organic, Inorganic, Biological, from Temple University, as he presents several new methodologies developed for reaction discovery.
In this webinar, you will learn:
- How to develop a fast and modular workflow for reaction discovery on a budget
- The advantages to using Advion-Interchim Scientific suite of instruments
- A review of unpublished work on developing new reaction discovery
Streamlined Benchtop Chemistry: Faster Workflow from Reaction to Fraction
Lab Manager Ask the Expert Webinar. Recorded September 7, 2022
Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how to avoid them to improve your process.
As a viewer, you will learn more about:
- How to use TLC plates to make flash purification faster and more efficient
- Software hacks leveraging sophisticated algorithms for better purifications
- 30-second fraction ID to speed up the process
- How evaporation can be easier, faster, and more reliable
Webinar speakers include:
Gary Williams
Vice President, Chemist & North American Sales
Advion Interchim Scientific
Nathaniel Kunzer
Product Specialist
Heidolph
Helium Shortages in the Chemistry Lab: Compound Characterization Using Helium-Free Techniques
Helium shortages are not new – annually, scientists see the cost of helium rise and fall like the stock market. Except this isn’t just a financial impact. Global helium shortages threaten to derail research and essential industry functions, taking down GC and high-field NMR instruments, bringing a once state-of-the-art lab down to a bare-bones facility.
This whitepaper explores the use of alternative reaction monitoring technology, including the expression® CMS (Compact Mass Spectrometer), Plate ExpressTM TLC Plate Reader, and ASAP® probe for liquid and solid samples – all helium-free alternatives for the chemistry laboratory.
Reaction Monitoring Capabilities at the Bench:
- The expression® CMS offers an ideal reaction monitoring solution that will live on long beyond the helium shortage and become a centerpiece of the lab. The system offers a complete solution for:
- Batch and flow chemistry
- Fast compound identification and purity determination
- …with little or no sample preparation required, and many novel sample introduction interfaces