Direct Mass Analysis of TLC Plates

Plate Express™ is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion Interchim Scientific’s expression® Compact Mass Spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

Suzuki Reaction Monitoring Using Compact Mass Spectrometry with TLC Interface

This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion Interchim Scientific expression® compact mass spectrometer (CMS) and Plate Express™ interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination of reaction mixture components without the need for off-line TLC sample preparation procedures.

Natural Product Analysis Using Compact Mass Spectrometry with Polarity Switching and In-source CID

Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the  pharmaceutical drug development process and consequently half of all currently approved  drugs in the US are based on natural products. It is therefore not surprising that natural product analysis is a field of major interest world wide. Here, we present a simple example  of the added benefits of mass spectrometry in typical natural product analysis workflows based on an alcoholic extract of nutmeg.

The expression compact mass spectrometer (CMS) is a novel high performance, easy-to-use single quadrupole mass spectrometer with enhanced scan speed and the ability for on-line polarity switching and in-source fragmentation.

THC Plant Material Analysis Using Compact Mass Spectrometry for Product Control and Law Enforcement of cannabis-related Plant Products

Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible  analysis methods for the detection and quantification of plant  metabolites are required, mass spectrometry is the detector of  choice.

Here, we present two simple workflows for the analysis of cannabinoids such as the naturally occuring cannabinol (CBN), the psychoactive ingredient of cannabis sativa,  tetrahydrocannabinol (THC) and the degradation product cannabidiol (CBD). Both TLC/FIA/CMS for qualitative detection  of cannabinoids, as well as HPLC/CMS for the quantitative determination of THC demonstrate the added benefit of compact mass spectrometry in the analysis of natural products.

expression® CMS: Mass Spectrometers Designed for Chemists

With decades of mass spectrometry and chemistry expertise, Advion Interchim Scientific has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting.

The Advion Interchim Scientific expression® compact mass spectrometer (CMS) is a fast and easy analytical tool for the organic chemist. Ideal for fast reaction monitoring, the expression® CMS features a single quadrupole that can adapt to multiple ionization sources in seconds, including both ESI and APCI. The mass spectrometer works in a variety of applications, including food and beverage, pharmaceutical, biomedical, peptides and proteins, drug discovery and more. The expression® CMS offers a variety of novel sampling techniques, including:

  • Direct mass analysis of TLC plates in 30 seconds at the push of a button with Plate Express™
  • One-touch analysis of solids and liquid samples with the ASAP® probe
  • LC/CMS
  • Many more options and configurations to suit your needs

Learn more about the different sample techniques available with the expression® CMS, including fast assay methods for liquids, solids, gases, and even air-sensitive compounds.

Fill out the form to download the full expression® CMS brochure now.

Screening of explosive residues without sample preparation using a direct sample analysis probe on the expression® CMS

The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to detect trace amounts of explosive residues.

The expression® Compact Mass Spectrometer (CMS) with an Atmospheric Solids Analysis Probe (ASAP®) is a high performance instrument with a small footprint that allows airports to better screen for explosive residues on passengers and their belongings.

The expression® CMS provides rapid and accurate detection with significantly reduced false-positives and false-negatives than ion mobility instruments.

Rapid Determination of Aflatoxins in Corn Flour by LC/CMS

Aflatoxins (B1, B2, G1, G2) produced by certain fungi (Aspergillus flavus and Aspergillus parasificus) are toxic metabolites which have been associated with various diseases, such as aflatoxicosis, in livestock, domestic animals and humans throughout the world. Many methods can be used for Aflatoxins analysis, including TLC, HPLC, immunoassay, LCMS etc. Of all the methods, the LC/MS method is considered the preferred technique because of its high selectivity and sensitivity. In this presentation, a simple, cost effective LC/CMS analytical approach is described for the determination of Aflatoxins.

Direct Sample Analysis of “Fizzy Drinks”

Chemists are tasked with quickly identifying compounds created, ensuring quality of products or evaluating safety. Current techniques are adequate, but not all offer speed, data quality or ease-of-use provided by the expression® Compact Mass Spectrometer (CMS). The expression® CMS with the direct analysis probe (ASAP®) offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.

LC/MS Determination of Amino Acids Using Compact Mass Spectrometry

A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.