Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.
iASAP: How it Works
The inert Atmospheric Solids Analysis Probe (iASAP) allows easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glovebox or Schlenk line.
Quant Express – Mass Express 4.0 Software with Quantitation
Quant Express, an addition to Advion’s user-friendly Mass Express 4.0 software suite, features quantitation to create a fully integrated software system for expression CMS users.
Peak Express™ Software: For the Analytical Chemist
Introducing a new type of mass spectrum, available exclusively in the Advion Peak Express™ software suite: the Delta Spectrum (ΔS). The ΔS is available with the expression compact mass spectrometer (CMS) to look beyond chemical noise and automatically detect even the smallest peaks without knowing the m/z in advance.
With the Peak Express™ software, you can:
- Find minor components and impurities you would otherwise miss
- Find unknowns in complex samples like natural products
- Acquire XIC-quality data while scanning the entire mass range, allowing Peak Express™ to tell you the m/z
- Perform real-time, mass-directed purification without knowing the mass Realize automatic ‘expert’ data processing
TAMI Molecular Identification Software Suite for expression® CMS
Turn your expression® CMS into a high resolution, exact mass instrument in its ability to provide elemental formulae. TAMI uses accurate centroiding and mass correction algorithms to provide a more accurate mass assignment. In combination with isotope abundance analysis and careful consideration of chemical valence rules this provision of elemental formulae with a high level of confidence.
TAMI includes a post-run mass calibration tool that further increases the mass accuracy of your data. TAMI software is accessed directly from Data Express as you process your data.
University of Leiden, Biosyn Group
Q: WHAT IS THE FOCUS OF YOUR LAB’S RESEARCH?
A: The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop synthetic methodology or as an inspiration for mimetic design.
Q: WHAT WAS YOUR PREVIOUS EXPERIENCE?
A: I started as organic chemist on Pt-adducts on self-made DNA fragments under supervision of Professor Dr. J. Reedijk. Following that, I switched to synthesis of bio-organic molecules on solid support under supervision of Professor Dr. J.van Boom. Currently I am working with sophisticated analytical equipment including many (prep) LCMS systems under supervision of Professor Dr. H. Overkleeft. With this equipment we show our facility to many other workgroups within and outside the University of Leiden.
Q: WHY DID YOU INCORPORATE THE EXPRESSION CMS INTO YOUR LABORATORY?
A: It’s easy, walk-up use with straightforward swapping of ESI and APCI sources make it a reliable, productive tool for determining synthetic success.
Q: HOW DID THE EXPRESSION CMS HELP RESOLVE YOUR CHALLENGES?
A: I incorporated the expression CMS as TLC/MS system because of its simplicity, low cost and the brilliant combination with the Plate Express (as a TLC interface).
Q: TO WHOM WOULD YOU RECOMMEND THE EXPRESSION CMS?
A: I recommend the expression CMS to people who want to use a robust system with simple handling (like organic chemists).
Creighton University, Department of Chemistry
Q: WHAT IS THE FOCUS OF YOUR LAB’S RESEARCH?
A: The synthesis of modified histidines for solid-phase peptide synthesis and new routes to exocyclic allenes.
Q: WHAT WAS YOUR PREVIOUS WORK FLOW OR CHALLENGE?
A: Some Nim-tritylated histidine analogues and exocyclic allenes provided weak or no molecular ions using other mass spectrometry methods.
Q: WHY DID YOU INCORPORATE THE EXPRESSION® CMS INTO YOUR LABORATORY?
A: It’s easy, walk-up use with straight-forward swapping of ESI and APCI sources make it a reliable, productive tool for determining synthetic success.
Q: HOW DID THE EXPRESSION® CMS HELP RESOLVE YOUR CHALLENGES?
A: ESI and APCI resolved extensive fragmentation observed with some analytes.
Q: TO WHOM WOULD YOU RECOMMEND THE EXPRESSION® CMS?
A: Organic synthesis labs and undergraduate programs needing a simple diagnostic tool for reaction outcomes.
Q: WHAT IMPRESSES YOU THE MOST ABOUT THE EXPRESSION® CMS?
A: Students find it straight-forward to use and its sources are easy to clean.
The Role of Mass Spectrometry in the Drug Discovery Unit’s Workflow – Medicinal Chemistry & the Advion CMS
The Drug Discovery Unit at the University of Dundee is met daily with a global task: address unmet medical needs and diseases in the developing world, and continuously build their innovative targets portfolio.
Learn from Susan Davis, a Medicinal Chemist with the unit, how she has processed 22,639 sample injections via the Advion compact mass spectrometer, and how it has assisted her research daily.
Also hear from Dr. Jack Henion, Advion’s Scientific Founder, as he joins for a Q&A session about mass spec and it’s role in drug discovery and disease prevention.
This webinar examines the workflow of a medicinal chemist as they utilize compact mass spectrometry techniques for drug discovery and disease prevention.
Identification of a Pesticide Used in Lawn Care by vAPCI Compact Mass Spectrometry
At regular intervals throughout the year a local lawn service applies pesticides to the lawn surrounding the Advion headquarters in Ithaca, NY. The grass is very uniform and not a single dandelion or crabgrass plant is visible – so we wondered, what chemical do they use? After an application in the early spring, we sampled the yellow pellets and utilized the Advion expression® CMS (compact mass spectrometer) coupled with a vapor Atmospheric Pressure Chemical Ionization (vAPCI) ion source to determine the unknown chemical.
Analyses of Different Grades of Olive Oil by Volatile Mass Spectrometry
In this application note, we demonstrate the use of the Advion Interchim Scientific expression® CMS with a volatile APCI (vAPCI) ion source to analyze extra-virgin, virgin, and lampante olive oil samples. We show statistical analysis allowing us to categorize and identify olive oil samples by their grade. This technique allows us to test individual olive oil samples and determine if they are truly extra-virgin, virgin, or lampante grade.