Maximize your analytical spectroscopy workflow in pharmaceutical applications—even with limited space at the bench. This session features innovative solutions for streamlining everyday needs in the lab, including reaction monitoring utilizing fast, prep-free sample introduction techniques for answers in seconds. You will also learn the latest technology in heavy metal analysis, as well as purification tools to maximize your scale-up efforts.
As a viewer, you will learn more about:
How to obtain direct mass analysis from TLC plates in seconds
Prep-free mass sampling techniques such as a direct analysis probe
How heavy metal analysis technology has improved for maximum use in the pharmaceutical lab
How scale-up needs can be met with the latest purification technologies
In this application note, we show how Cyanidin-3-glucoside can be extracted from black rice and purified with a prepLC/Flash system. The amount and purity of Cyanidin-3-glucoside was measured utilizing a certified reference standard.
In this application note, a method to separate and purify green tea catechins with preparative liquid chromatography (Prep-LC) using the puriFlash® 5.250 system is demonstrated. An additional HPLC-UV-MS method is also demonstrated for compound confirmation and purity analysis.
In this application note, a method to separate and purify 3 curcuminoids from turmeric powder using thin layer chromatography (TLC) with mass spectrometry and flash chromatography is demonstrated.
In this application note, we describe methods of isolating natural products from green tea and turmeric powder by mass-directed fraction collection during flash chromatography and preparative LC. For demonstration purposes, the isolated compounds were then additionally confirmed by Atmospheric Solids Analysis Probe (ASAP®) MS or HPLC-MS.
Recorded November 3, 2022: Featured talk in the LCGC Mass Spectrometry Symposium
Join Fadi Abou-Shakra, Director of ICP-MS Portfolio for Advion Interchim Scientific®, as he shares some of the organization’s latest mass spectrometry applications for the teaching lab. This includes student-friendly experiments using a compact single-quadrupole system, as well as simplified ICP-MS applications.
Fadi Abou-shakra started using ICP-MS in 1987 applying it for the analysis of trace elements in biological fluids and has been active in the field of atomic spectroscopy since then. He holds an MSc in Medical Physics and a PhD in Chemistry from the University of Surrey, England. He brings a wealth of experience in ICP-MS as a researcher, customer support specialist and a business manager.
Ask the Expert Webinar
Presented live November 2, 2022
Step inside the Parasram Lab at New York University for a look at some of their latest research.
In this webinar, Professor Marvin Parasram will discuss data from his laboratory’s recent publication, “Anaerobic Heteroatom Transfer Reactions Using Photoexcited Nitroarenes.” The research features developments on the anaerobic cleavage of alkenes into carbonyl compounds using nitroarenes as oxygen transfer reagents under visible light. This approach is a safe and practical alternative to mainstream oxidative cleavage protocols, such as ozonolysis and the Lemieux–Johnson reaction.
As an attendee, you will learn more about:
How a wide range of alkenes possessing oxidatively sensitive functionalities underwent anaerobic cleavage to generate carbonyl derivatives with high efficiency and regioselectivity, using the Advion Interchim Scientific puriFlash® 5.250 Preparative HPLC system.
Mechanistic studies support that the transformation occurs via direct photoexcitation of the nitroarene followed by a nonstereospecific radical cycloaddition event with alkenes.
How this process leads to 1,3,2- and 1,4,2-dioxazolidine intermediates that fragment to give the carbonyl products, using the Advion Interchim Scientific expression Compact Mass Spectrometer.
How a combination of radical clock experiments and in situ photoNMR spectroscopy revealed the identities of the key radical species and the putative aryl dioxazolidine intermediates, respectively.Watched the video and ready to learn more?
Join Daniel Kim, Ph.D., Assistant Professor Organic, Inorganic, Biological, from Temple University, as he presents several new methodologies developed for reaction discovery.
In this webinar, you will learn:
How to develop a fast and modular workflow for reaction discovery on a budget
The advantages to using Advion-Interchim Scientific suite of instruments
A review of unpublished work on developing new reaction discovery
Lab Manager Ask the Expert Webinar. Recorded September 7, 2022
Maximize your workflow—even with limited space at the bench. This webinar features innovative solutions for streamlining the chemists’ everyday needs, including reaction monitoring, purification, fraction collection, and evaporation. No matter what your application, the session will address some of the most common bottlenecks and how to avoid them to improve your process.
As a viewer, you will learn more about:
How to use TLC plates to make flash purification faster and more efficient
Software hacks leveraging sophisticated algorithms for better purifications
30-second fraction ID to speed up the process
How evaporation can be easier, faster, and more reliable
Webinar speakers include:
Gary Williams
Vice President, Chemist & North American Sales Advion Interchim Scientific
Helium shortages are not new – annually, scientists see the cost of helium rise and fall like the stock market. Except this isn’t just a financial impact. Global helium shortages threaten to derail research and essential industry functions, taking down GC and high-field NMR instruments, bringing a once state-of-the-art lab down to a bare-bones facility.
This whitepaper explores the use of alternative reaction monitoring technology, including the expression® CMS (Compact Mass Spectrometer), Plate ExpressTM TLC Plate Reader, and ASAP® probe for liquid and solid samples – all helium-free alternatives for the chemistry laboratory.
Reaction Monitoring Capabilities at the Bench:
The expression® CMS offers an ideal reaction monitoring solution that will live on long beyond the helium shortage and become a centerpiece of the lab. The system offers a complete solution for:
Batch and flow chemistry
Fast compound identification and purity determination
…with little or no sample preparation required, and many novel sample introduction interfaces
