iASAP – Mass Analysis of Air-Sensitive Samples, Catalysts and Organometallics at the Bench
The Atmospheric Solids Analysis Probe (ASAP™) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove box or Schlenk line to prevent oxidation.
The technique allows a synthetic chemist to perform real-time reaction monitoring by sampling the compound with the special iASAP probe, which is designed to provide access to the sample without disturbing the inert environment, then transferring the sample to the CMS, while continuing to protect it in an inert environment where it is ionized by atmospheric pressure chemical ionization (APCI). Mass Spectra are acquired in seconds.