Poster

Study of ionization efficiency on silicon-based, micro-fabricated electrospray nozzles for micro flow LC/ESI-MS applications

One of the benefits of nanoelecrtospray ionization (nanoESI) is the reported optimal ionization efficiency (equalized response) of chemically different analyses despite the presence of matrix components. However, outside of a very low flow rate of ca. 1-20 nL/min, the ionization efficiency drops exponentially and coupling higher flow rates from a typical liquid chromatography (LC) system to ESI loses most of the benefits such as enhanced sensitivity and reduced ion suppression in mass spectrometry analysis (LC/ESI/MS). The Advion silicon-based ESI Chip accommodates micro flow LC/MS applications at ionization efficiencies near optimal levels and comparable to nanoelectrospray ionization (nanoESI).

To download, please fill out the form below.

Advion respects your privacy. We will not give your email address to third parties or send you unwanted email.