Rapid Screening for Fentanyl in Urine Using a Compact Mass Spectrometer (CMS) with an Open Port Sampling Interface (OPSI)


Fentanyl, a fast-acting synthetic painkiller about 100 times stronger than morphine, is also the most widely used synthetic opioid medicine in 2017.1 Its abuse is becoming a public health problem. A quick and easy analysis method for this drug is in high demand from health practitioners and law enforcement agencies. 

The Touch Express™ Open Port Sampling Interface (OPSI),2,3 is designed for simple sampling of solids, liquids, sample preparation tips and fibers. Paired with the ESI of the expression CMS, the product incorporates an open port of continuous low-volume solvent, flowing directly into the ESI for MS analysis. Any soluble sample touching the open port will be analyzed by the mass spectrometer in just seconds. 

Here, a simple and quick analysis method for fentanyl in urine using Touch Express™ OPSI on the Advion expression CMS is presented.