Application with Mass Directed Preparative SFC Utilizing the JASCO Preparative SFC platform and Advion expression^® Compact Mass Spectrometer

In this study we evaluated the performance of a Preparative SFC‐MS system combining the JASCO Preparative SFC with the Advion expression^® CMS (Compact Mass Spectrometer) utilizing a simplified passive splitter for mass‐directed fraction collection. The initial test explored a wide range of flow rates both isocratic and gradient to test performance and reliability of the passive splitter, coinciding timing of MS and UV signal and the clearance of the source with highly concentrated samples.