Corden Pharma Switzerland LLC, Liestal, Switzerland

Q: WHAT IS THE FOCUS OF YOUR LAB’S RESEARCH?
A: Our work is focused on the development and implementation of chromatographic purification processes, ranging from mg to 100 kg scale. Many compounds of interest lack chromophores and cannot be detected by classical UV detection.

Q: WHAT WAS YOUR PREVIOUS WORKFLOW AND EXPERIENCED CHALLENGES? 

A: In the past, the fraction collection during preparative HPLC was very time consuming as we had no indicator when the compound of interest was eluting in the chromatographic process in case it was not UV-active. All fractions had to be analyzed by TLC and in many cases additionally with HPLC and Corona detection before we could identify the fractions of interest.

Q: WHY DID YOU INCORPORATE THE EXPRESSION^® CMS INTO YOUR LABORATORY? 

A: We use the Advion Interchim Scientific expression^® CMS as a robust and versatile detector in our chromatographic processes, both MPLC and HPLC. The data transfer into the control software of our prep HPLC systems was straightforward. The Advion MS is shared with our R&D department for more conventional applications and gave both departments very quick access to MS data. Both departments appreciated the quick set-up, the user-training, and the reliable after sales service whenever a question pops up.

Q: TO WHOM WOULD YOU RECOMMEND THE EXPRESSION^® CMS? 

A: The Advion MS is a robust instrument that can be used in different environments. It does not require a lot of training and is easy to understand. Whenever you have a need for MS data, be it online or offline, Advion MS might give you very easy access to the data you need.