Developed in collaboration with Oak Ridge National Laboratory*, the liquid extraction surface analysis (LESA) capability of the TriVersa Nanomate® enables simple, direct ESI mass spectrometric analysis from a variety of surfaces.
Presented by: Dr. Tom Covey
In this web presentation Dr. Tom Covey describes how researchers can incorporate the fast, simple & direct method of LESA Clarity for AB SCIEX Mass Spec Systems into their labs. He shows data that illustrates how you can see more analytes with better sensitivity.
Presented by: Thomas Covey, Principal Research Scientist at AB SCIEX
Thomas Covey describes how various organizations are incorporating the fast, simple, and direct method of LESA – Liquid Extraction Surface Analysis – into their labs. He shows data that illustrates how you can see more analytes with better sensitivity by combining LESA with mass spectrometry and chip-based nanoESI via Advion’s TriVersa NanoMate. This new analytical technique has a wide range of applications for sample analysis from a variety of surfaces e.g. tissue slices, TLC plates, MALDI plates, and Dried Blood Spots.
Dr. Covey also demonstrates the latest LESA upgrade – LESA Points software that provides simple, point-and-click surface analysis. Users can scan a digital image of their samples and select sampling positions within 90-μm resolution. The new upgrade also provides a specially-developed mounting block that keeps all kinds of surfaces at a fixed height for simple method set-up.
Fuller, S.J.; Zhao, Y.; Cliff, S.S.; Wexler, A.S.; Kalberer, M.
Anal Chem. 2012 Oct 30. [Epub ahead of print]
Paine, M. R. L.; Barker, P. J.; Maclauglin, S. A.; Mitchell, T. W.; Blanksby, S. J.
Rapid Commun Mass Spectrom. 2012 Feb 29;26(4):412-18. [Epub 2 012 Jan 15]
Schadt, S.; Kallback, S.; Almeida, R.; Sandel, J.
Drug Metab Dispos. [Epub 2011 Dec 19]. doi:10.1124/dmd.111.043562
Walworth, M.J.; ElNaggar, M.S.; Stankovich, J.J.; Witkowski, C.; Norris, J.L.; Van Berkel, G.J.
Rapid Commun Mass Spectrom. 2011 Sep 15;25(17):2389-96.
Eikel, D.; Henion, J.
Rapid Commun Mass Spectrom. 2011 Aug 30;25(16):2345-54. doi: 10.1002/rcm.5107
Blatherwick, E.Q.; Van Berkel, G.J.; Pickup, K.; Johansson, M.K.; Beaudoin, M.E.; Cole, R.O.; Day, J.M.; Iverson, S.; Wilson, I.D.; Scrivens, J.H., Weston, D.J.
Xenobiotica. 2011 Aug;41(8):720-34. [Epub 2011 Jun 14]