Application Note

Using the TriVersa NanoMate® for Rapid Analyte Identification Based on Static nESI-MS/MS (Infusion MS/MS) Employing Polarity Switching Experiments

Automated static nano-ESI/MS/MS (Infusion MS/MS) is an easy-to-use and high-throughput approach to analyte identification. It is particularly useful in the field of shotgun lipidomics, which itself has great potential for biomarker discovery and gained some significant attention in the last couple of years (Schuhmann et al. 2012; Jung et al. 2011; Han et al. 2011).

In order to simplify shotgun lipidomic approaches even further, the TriVersa NanoMate can now change nano-ESI spray polarity within the same infusion experiment.