Application Note

Rapid Screening for Fentanyl in Urine using the Advion expressionL CMS with the Touch Express™ Open Port Sampling Interface (OPSI)

Quick and easy analysis methods for drugs of abuse are in high demand from health practitioners and law enforcement agencies on a global scale. In 2017, it was found that fentanyl, a fast-acting synthetic painkiller that is nearly 100 times stronger than morphine, has become the most widely abused synthetic opioid medicine – to the point it has become a public health problem. In this application note, a simple method for fentanyl screening in urine is introduced, using Advion’s Touch Express™ Open Port Sampling Interface (OPSI) coupled with the expressionL Compact Mass Spectrometer (CMS).

OPSI was developed by Gary Van Berkel and Vilnos Kertesz of Oak Ridge National Laboratory. Paired with the electrospray ionization (ESI) source of the CMS, Touch Express™ OPSI offers a fast assay benchtop solution in a small-footprint, easy-to-use system.