LC/MS Screening For EDTA In Fresh Blood Swabs Using the Advion Interchim Scientific expression^® CMS System

This application note suggests that a simple LC/MS screen of a relatively fresh sample of human whole blood collected from a lavender capped potassium EDTA anticoagulant blood sample applied to a cotton swab can be analyzed by full-scan positive ion or negative ion LC/MS using a compact single quadrupole mass spectrometer (expression^® CMS). A presumptive positive determination from such a test would benefit from confirmation by LC/MS/MS or other definitive confirmative analytical technique.