Complement Flow Synthesis With In-Line Purification Using Flash Chromatography

In this application note, we describe a novel method to perform the continuous isolation of flow synthesis products from residual starting materials, catalysts or by-products to expedite chemical discovery. A promising new approach is highlighted here, featuring the Advion Interchim Scientific puriFlash^® 5.250 preparative LC system.

The first results of our cooperation with the VilelaLAB and Continuum Flow Lab at Heriot-Watt University, Edinburgh, on this topic are outlined here and can be read in more detail in the following source: C.G.Thomson et al.: Expanding the Tool Kit of Automated Flow Synthesis: Development of In-line Flash Chromatography Purification, J. Org. Chem. 2021, 86, 20, 14079–14094.