Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS

The analytical verification of compounds in organic syntheses is a challenging task. The sample is often directly taken out of the reaction mixture and therefore contains many impurities and matrix components. As a result, low-level sample preparation combined with a direct analysis method is highly beneficial. TLC/MS (thin layer chromatography – mass spectrometry) is such an analytical technique.

Co-authored with Merck Millipore in Darmstadt, Germany, this application note demonstrates a normal phase TLC/CMS technique for the rapid determination of 4-aminobiphenyl in its reaction mixture.

For the application note on the TLC/CMS determination of 4-aminobiphenyl in reverse phase, click here.