Resource Center

Cocaine is a globally used illicit drug and its widespread use remains a significant public health concern. It is known that US paper currency in general circulation is contaminated with cocaine. There are several possible explanations for this: contamination due to handling during drug deals, the use of rolled up bills for snorting or inhalation, …

Cannabis and hemp products are becoming much more available for medicinal and recreational use making routine testing for toxic heavy metals much more important. Advion Interchim Scientific® introduces the SOLATION® ICP-MS for the analysis of heavy metals in cannabis plant and cannabis product samples. While there are no federal guidelines for heavy metals in cannabis, …

Flash chromatography has traditionally used UV absorption as the main method of detection for compounds during a purification process. While UV absorption is broadly applicable to many classes of compounds, it has limited specificity to individual compounds in a mixture and misses classes of compounds that do not carry chromophores. Mass-directed fraction collection gives users the ability to collect …

Mass spectrometric techniques are typically divided into two distinct fields: atomic and molecular. Liquid sampling – atmospheric pressure glow discharge (LS-APGD) has been developed as a versatile ionization source capable of combined atomic and molecular (CAM) analysis. To date, the LS-APGD has demonstrated impressive results in U isotope ratio analysis as well as molecular analysis across …

Patulin is a mycotoxin that is a common contaminant in food and animal feed, especially in apple products. The potential health risk of patulin to humans led to the establishment of action levels in foodstuffs. The EU, WHO and US FDA defined maximum levels of patulin in fruit juices. The EU also has specific regulations for …

Using separation from the AVANT™ UHPLC system coupled to the expression® Compact Mass Spectrometer (CMS), cannabinoids from commercially available CBD oils are measured for concentration against product label claims for a comparative test. This poster was presented at the 2019 Cannabis Science Conference East in Baltimore, MD.

We demonstrate a cost-effective UHPLC/CMS method for the analysis of chloramphenicol in milk with a detailed discussion of sensitivity, linear response range, carryover and robustness using the Advion expression® Compact Mass Spectrometer (CMS) and Advion AVANT™ UHPLC System. This poster was presented at the 2019 ASMS Conference on Mass Spectrometry and Allied Topics in Atlanta, …

Introduction Electrospray mass spectrometry (ESI-MS) is a versatile analytical tool for biomolecular protein analysis and proteomics. One important area is to study protein structure and composition in which peptides and proteins can be ionized with multiple charges via electrospray ionization. Based on the charge envelope, the molecular weight can be easily determined using manual or …

Overview A simple, sensitive and selective ASAP® sample introduction approach to measuring the presence of two isobaric compounds, CBDA and THCA, contained in a complex sample such as hemp or cannabis plants or their corresponding extraction products. Measurements are made of differences in the relative composition of CBDA and THCA fragment ions originating from the …

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although immunoassay …

Introduction Fentanyl, a fast-acting synthetic painkiller about 100 times stronger than morphine, is also the most widely used synthetic opioid medicine in 2017.1 Its abuse is becoming a public health problem. A quick and easy analysis method for this drug is in high demand from health practitioners and law enforcement agencies. The Touch Express™ Open …

Introduction The legalization of marijuana and hemp provides commercial opportunities as well as analytical challenges. Accurate and precise quantitative analysis of plant and medicinal products is needed in this new industry to document composition and assure the safety of cannabis products. LC/MS techniques can provide unparalleled selective and sensitive measurements for these purposes. Here we …

Overview Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ molecules from analytes not MS accessible by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on a compact single quadrupole mass spectrometer (CMS) provides a cost-effective …

Introduction Metal based compounds have found utility in various fields such as clinical, energy, food safety and environmental to name a few. Creating the metal complex is the last step in a synthetic process when ligands are bound to the metal center. Once made, these metal complexes can be used anywhere from stereospecific synthesis to …

Executive Summary: LESA and LESAplus liquid chromatography provide novel surface analysis tools for the spatial resolution of analytes from a wide variety of surfaces. Whole body or organ sections in particular can be probed for small molecules, lipids and proteins with a resolution of 400 – 1000μm. Commercial solution allows for automated processing of samples (Advion TriVersa NanoMate® …

Overview: Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer. This technique allows for the rapid investigation (<30 sec) of material suspected of containing trace amounts of explosive residues. The expression® Compact Mass Spectrometer (CMS) with an Atmospheric Solids Analysis …

Bacteria can be benign, beneficial and harmful, for more than 70 years we have been combatting these microscopic creatures with antibiotics. Increasingly though strains of antimicrobial resistant bacteria are becoming commonplace. This has motivated numerous studies aimed at deciphering the evolution of antibiotic resistance. Volatile Organic Compounds (VOCs) are ubiquitous in nature and are produced …

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP®) without …

The novel Peak Express™ technology was evaluated and applied to natural product extracts. Peak Express™ utilizes delta ion currents, a differential ion current with significantly improved signal-to-noise as well as enhanced detection ability for low abundance compounds.

A rapid unknown sample analysis is performed using a novel volatile APCI source with CMS detection and on-line database search.

Cost effective, multidimensional GRAS (generally recognized as safe) counterfeit protection of drugs based on uniformly 13C labeled amino acids with compact mass spectrometry detection.

One of the benefits of nanoelecrtospray ionization (nanoESI) is the reported optimal ionization efficiency (equalized response) of chemically different analyses despite the presence of matrix components. However, outside of a very low flow rate of ca. 1-20 nL/min, the ionization efficiency drops exponentially and coupling higher flow rates from a typical liquid chromatography (LC) system …

A recent development in mass spectrometry is the design of smaller sized MS systems with full analytical capability (compact mass spectrometry, CMS). CMS systems with fragmentation analysis are very cost effective analysis solutions and ideally suited for reaction and quality control in SPPS including detailed product characterization3. Here, we evaluate the utility of a system …

P. P. Hurtado1, E., Palmer1, C. Aldcroft2, H. Moore2, A. Baker2. M. Allen2, J. Jones2, M.A. Turner1, J.C. Reynolds1 1Centre for Analytical Science, Department of Chemistry, Loughborough University, Ashby Road, Loughborough, Leicester, LE11 3TU, UK 2Advion UK Ltd The development of new interfaces that enable direct analysis of VOCs represents an attractive and low cost …

Economic adulteration of milk involves adulteration with nitrogen-rich compounds to interfere with the widely used Kjeldahl protein assay and inate the total protein content result for economic gains. The economic adulteration issue garnered global attention during the melamine scandal in 2007 which resulted in the sickening and deaths of infants fed with adulterated milk powder. …

The purpose of this study was to evaluate the positive and negative electrospray (ESI) and atmospheric pressure chemical ionization (APCI) LC/MS ion current response from a representative synthetic mixture of standard pharmaceutical compounds. The selected drup compounds were prepared as an equimolar mixture and analyzed by an optimized gradient LC/MS procedure using a novel compact …

The expression® compact mass spectrometer (CMS) was developed based on decades of chemistry and mass spectrometry experience specifically to meet the needs of chemists. Many chemists are asked to perform their work in the field, and the CMS was built to be versatile. It is available with a TACOM-compliant Mobile Attenuation Mounting (MAM) system. This allows the …

In this study we evaluated the performance of a Preparative SFC‐MS system combining the JASCO Preparative SFC with the Advion expression® CMS (Compact Mass Spectrometer) utilizing a simplified passive splitter for mass‐directed fraction collection. The initial test explored a wide range of flow rates both isocratic and gradient to test performance and reliability of the …

There is a concerted effort by regulatory bodies, such as the EPA to reduce the exposure of environmental contaminants, such as inorganic anions to humans and the environment. Achieving lower analytical detection limits of hazardous compounds in environmental matrices such as water, soils and sediments allows regulatory bodies to make better informed decisions on the …

In natural product research the isolation of compounds from crude extracts is a key element. An increase in the efficiency of the purification process, by improvement of instrumental and methodological approaches, remains a crucial point. In this respect, modern flash chromatography, has evolved and uses 15 μm spherical particles for efficient separation at moderate pressures. …

A novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions. Medical chemists are routinely faced with personally over a hundred new chemical entities (NCE’s) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route.