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With any growing lab, scientists find an increasing list of needs to improve in throughput, capabilities, or just the addition of staff to your team. This can result in several outcomes that make it difficult to meet environmental and sustainability goals, or a laboratory’s bottom line. By building flexibility in your lab with multi-use instrumentation, …

In this application note, scientists from GEOMAR Helmholtz Centre for Ocean Research Kiel research residual TNT in the water phase from dumped weapons throughout the southwestern Baltic Sea. The Advion Interchim Scientific® expression® Compact Mass Spectrometer (CMS) is used for real-time sample detection of explosive chemicals released from these underwater relic munitions.

Genius Method Development Software: Your daily assistant for automated method transfer Recorded Thursday, October 24, 2024 With any system in the puriFlash® range, you will benefit from Genius, the artificial intelligence of the InterSoft® X software suggesting the best purification method for you based on your TLC and HPLC data. No matter how skillful you …

Product in Action Webinar Recorded Thursday, July 11, 2024, featured on LabManager.com Make your sample preparation process more reliable and secure. The SPE-LV6 is a fully automated positive pressure workstation for sample preparation by SPE solid phase extraction. Specially developed for all analytical chemists looking for performance and alternatives to manual use, the SPE-LV6 ensures …

Andrew F. Worrall, Craig D. Campbell, Megan O. Midson, Malcolm I. Stewart Abstract Mass spectrometry (MS) is introduced to high school students in the UK in many pre-university course syllabi. As such, we have identified the use of MS as a key technique that should be taught practically to undergraduates from the outset of their …

How it Works Webinar Please join us for an insightful webinar where we’ll focus our discussion on the qualitative analysis of oligonucleotides using the HPLC-UV/MS method. Discover how this approach can offer you purity analysis, and molecular weight determination through charge deconvolution, etc., and gain access to valuable tricks and tips for optimizing oligonucleotide analysis. …

This Webinar was originally presented March 7, 2024 on LabRoots.com ABSTRACT The latest purification systems are not like those of the past — you do not have to choose between flash and PrepLC. Now, you can have both with the ability to decide your needs with one user-friendly system. In this webinar, you will learn …

Jack Henion, Changtong Hao, Daniel Eikel, Olof Beck, and Peter Stambeck* Abstract Increased acceptance of cannabis containing the psychoactive component, Δ9-tetrahydrocannabinol (THC), raises concerns about the potential for impaired drivers and increased highway accidents. In contrast to the “breathalyzer” test, which is generally accepted for determining the alcohol level in a driver, there is no …

This Webinar was originally presented November 9, 2023 on LabRoots.com ABSTRACT In this webinar, you’ll learn how to address your lab’s purification pain-points with methods and instrumentation to maximize your budget, time and increase overall efficiency. During this session you will discover: How to select the ideal purification solution for your lab’s specific needs How …

This whitepaper explores the use of alternative chromatography technology for faster, more efficient analysis over traditional LC/MS runs. Plate Express™ is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, combined with the Advion Interchim Scientific® expression® CMS (Compact Mass Spectrometer) creating a technique known as TLC/CMS. Using …

Cameron J. Stouffer and R. Kenneth Marcus * Abstract Cloth swipes are a fairly common sampling modality, having relevance across a wide variety of applications including environmental analysis, forensics, and bioassays. One of the biggest attractions of swipes (and related paper substrates) is the ease of sample collection and transportation, where just the swipe of …

Oligonucleotides have gained significant attention in biopharmaceutical development due to their ability to modulate gene or protein expression. This application note aims to demonstrate the HPLC/UV analysis of multiple oligo samples and utilize HPLC/CMS analysis to determine their molecular weight.

In this application note, we use whey protein isolate and two casein macro peptides as an example to demonstrate the isolation and purification of bioactive peptide components with a system comprised of a puriFlash® 5.250 prepLC coupled online to an expression® CMS detector.

Shaun N. Robertson, Fadi Soukarieh, Thomas M. White, Miguel Camara, Manuel Romero*, and Rian L. Griffiths* Abstract Previously, metabolites diffused or secreted from microbial samples have been analyzed via liquid chromatography–mass spectrometry (LC–MS) approaches following lengthy extraction protocols. Here, we present a model system for growing biofilms on discs before utilizing rapid and direct surface …

A book of experiments for your students The expression® CMS (Compact Mass Spectrometer) is the ideal instrument for the teaching lab thanks to its small size, ease of use, and one-click software. This pocket guide of classroom experiments offers students the ability to gain hands-on instrument experience by eliminating complex and difficult sample preparation.

In this application note, we demonstrate a complete solution for the synthesis, purification, and quantitation of Gd(III)-DOTA, an ionic imaging contrast agent with better chemical stability and lower toxicity compared to the currently used Gd-(DTPA).

In this application note, we present a fast method for routine analysis of small volume blood samples for key toxic and essential elements using the Advion Interchim Scientific® SOLATION® Inductively Coupled Plasma Mass Spectrometer (ICP-MS) using a simple “dilute and shoot” sample preparation.

Iohexol is a widely used non-ionic imaging agent that improves contrast for x–ray analysis. Its low osmolality allows for a rapid clearance via the kidney, preventing reabsorption and further metabolization. This makes iohexol a compound with a better safety profile compared to other imaging agents. In this application note, a simple and accurate HPLC-CMS method …