Blog

April 6, 2018

Join our Webinar: Self-optimising Continuous Flow Reactors

Join us for a webinar with Chris Horbaczewskyj from the University of Leeds and Jack Henion, Advion’s Chief Scientific Founder on Thursday, April 26, 2018. Chris is working on the self-optimisation of continuous flow reactions using online mass spectrometry. Continuous flow and process optimisation are relatively new methods involved in chemical synthesis. This webinar outlines the workflow of the Bourne group at the University of Leeds for process development applications.
Register for this webinar to learn more!

Find out more »
April 6, 2018

Self-Optimising Continuous Flow Reactors Webinar

Join us for a Webinar with Chris Horbaczewskyj of the University of Leeds and Jack Henion, Advion’s Chief Scientific Founder, on Thursday, April 26, 2018 at 10am EST / 3PM GMT.

Chris Horbaczewskyj of University of Leeds and Jack Henion, Advion's Chief Scientific Founder

This presentation outlines the work carried out within the Bourne group at the University of Leeds for process development applications:

  1. Use of flow chemistry with online HPLC in the self-optimisation of reactions
  2. Use of online mass spectrometry for the optimisation of continuous flow reactions using an experimental design approach
  3. The development of new algorithms for multiple variable optimisation in chemical systems

September 5, 2017

Join Advion at Supply Side West in Las Vegas!

Join us on the expo floor September 27-28 in Las Vegas, NV! If you’re attending the expo, analytical testing for ingredients is essential for every supplier and buyer. Stop by to learn how Advion’s instruments can streamline your internal labs and help you ensure you have pure, quality, pesticide-free product.

Please stop by booth #XX117 to learn more about Advion’s full array of mass spec testing tools, featuring easy-to-use, novel sample techniques for maximum efficiency in the lab.

Find out more »
August 31, 2017

Join Advion at SupplySide West in Las Vegas! Booth #XX117


Join us on the expo floor September 27-28 in Las Vegas, NV! Analytical testing for ingredients is essential for every supplier and buyer. Stop by to learn how Advion’s instruments can streamline your laboratory workflow and help you ensure you have safe, high-quality products.

Visit booth #XX117 to learn more about our full array of mass spec tools for testing, featuring easy-to-use, novel sample analysis techniques for maximum efficiency in the lab.

Several successful applications of the Advion expression Compact Mass Spectrometer (CMS) system for food and ingredients testing include:

  • The Analysis of Different Grades of Olive Oil by Volatile Mass Spectrometry: In this application note, we demonstrate the use of the Advion expression CMS with a volatile APCI (vAPCI) ion source technique that allows testing of olive oil samples to determine if they are truly extra-virgin, virgin, or lampante grade.
  • Classifying cheeses by volatile APCI Compact Mass Spectrometry: In this application note we demonstrate the capability of the Advion expressions CMS to analyze volatile fatty acids of various types of cheeses using our volatile vAPCI ion source.
  • A Sudan Dyes Analysis Using Compact Mass Spectrometry with a TLC Interface: In this note, a TLC/CMS method using the expression CMS coupled with the Plate Express interface is introduced for the detection of 7 Sudan dyes in a chili matrix. 
  • Chemically Tracking Spoilage of Meat Using Volatile Compact Mass Spectrometry: This application note demonstrates the use of the Advion expression CMS coupled with a vAPCI ion source to directly detect several key chemicals given off by meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured over several days as meat spoiled.
  • Looking for more SupplySide West details? Visit the official site for lectures, exhibitors, social events and more!

Background: SupplySide West brings together more than 15,000 ingredient buyers and suppliers from the dietary supplement, beverage, functional food, personal care and sports nutrition industries. SupplySide West is all about the science and strategy around the development of finished products that drive the global business economy. Join us this year to learn about new trends from over 1,200 exhibitors and 140 hours of educational and conference programming. The 2017 SupplySide West event takes place in Las Vegas, NV, September 25-29. The expo floor where Advion will be located is open September 27-28. We hope to see you at SupplySide West 2017!

August 8, 2017

Join Advion at ACS Fall 2017 in Washington DC

Join us on the expo floor August 20-22 in Washington, DC for the annual Fall American Chemical Society conference. Here you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #1401 to learn more about Advion’s full array of MS tools for chemists.

This year, we are hosting a workshop titled, “Mass Spectrometry for Chemists – Direct Analysis of TLC Plates, Solids, Liquids and Gases.” 

Date/Time/Location: Tuesday, August 22, 9:30a-12p — Room 4 on the Conference Floor, complimentary breakfast will be served

Find out more & register for the workshop now »
August 2, 2017

Join Advion’s Workshop at ACS Fall 2017 in Washington D.C. & at Booth #1401

Join us on the expo floor August 20-22 in Washington, DC for the annual Fall American Chemical Society conference. Here you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #1401 to learn more about Advion’s full array of MS tools for chemists.

This year, we are hosting a workshop titled, “Mass Spectrometry for Chemists – Direct Analysis of TLC Plates, Solids, Liquids and Gases.” 
Date/Time/Location: Tuesday, August 22, 9:30a-12p — Room 4 on the Conference Floor, complimentary breakfast will be served
Description:With the daily need to analyze a variety of solids, liquids and gases sample techniques are indispensable in a busy lab. Learn how a single instrument can be adapted to each of these sample requirements and rapidly changed to accommodate back-to-back assays. Listen to users in the field speak about innovative sample inlets, including:

  • TLC/CMS
  • ASAP® (Atmospheric Solids Analysis Probe) – now compatible with air sensitive compounds with the addition of the iASAP probe
  • Direct flow injection
  • vAPCI for analysis of headspaces

Learn how they reduced sample preparation and streamlined their everyday workflow. Also learn about two new exciting product launches from Advion.

Featured Speakers:

  • David Patteson, Advion President & CEO
  • Jack Henion, Ph. D., Advion Co-Founder and Chief Scientific Officer, Emeritus Professor, Cornell University
  • John Matson, Ph. D., Matson Research Group on Macromolecular and Supramolecular Chemistry, Assistant Professor, Virginia Tech – Peptide-Based Materials for Controlled Delivery of Hydrogen Sulfide
  • Keri Colabroy, Ph. D., Associate Professor of Chemistry, Muhlenberg College & Brock Juliano, Student – CMS assisted identification of Small-Molecule, Bacterial Metabolites Using ESI with Direct Injection
  • Neil Vasdev, Ph. D., Vasdev Lab at Massachusetts General Hospital, Director of Radiochemistry, Associate Professor of Radiology, Harvard – Applications of the CMS in a Radiochemistry Lab

Advion will also launch two new technologies in to the expression CMS family:

Looking for more ACS details? Visit the official site for lectures, exhibitors, posters, social events and more!

Background: The American Chemical Society National Meeting takes place in the spring and fall each year, offering the latest in chemistry developments, achievements and awards. The 2017 ACS fall meeting is in Washington, D.C., August 20-24. The expo floor where Advion will be located is open August 20-22. We hope to see you at ACS Fall 2017!

June 27, 2017

ASMS 2017 Advion Highlights

ASMS 2017 brought nearly 7,000 attendees under one roof, ready to learn the newest products and latest applications in the world of mass spec. The Advion CMS and TriVersa NanoMate were both a topic for discussion, featured during Advion poster sessions, and also included in posters from customers who have found the instruments an essential part of their mass spec workflow.

See the Highlights »
June 27, 2017

ASMS 2017 Advion Highlights

ASMS 2017 brought nearly 7,000 attendees under one roof, ready to learn the newest products and latest applications in the world of mass spec. The Advion CMS and TriVersa NanoMate were both a topic for discussion, featured during Advion poster sessions, and also included in posters from customers who have found the instruments an essential part of their mass spec workflow.

Click on any of the posters or presentations to view full size.

The TriVersa NanoMate was featured in the following posters and presentations:

POSTER: Histology Directed Liquid Surface Extractions Coupled Directly to Liquid Chromatography for Improving Identification Strategies in Advanced IMS Applications – Vanderbilt University



POSTER: Lipid parameters associated with obesity identified using a high-throughput Shotgun Lipidomics technology – Thermo Fisher Scientific and Lipotype


POSTER: Native LESA mass spectrometry: Direct analysis of proteins and their complexes – University of Birmingham, University of Oxford


 


POSTER: A Rapid Mixing Device to Detect Early Intermediates in Hepatitis B Virus Assembly by Charge Detection Mass Spectrometry – Indiana University


POSTER: Isomeric Complexity of Glycosylation in MCF-7 and MDA-MB-231 Cell Lines Revealedby Detailed Analysis with Ion Trap Mass Spectrometry – Glycan Connections, LLC / University of New Hampshire, Durham


POSTER: Simultaneous Label-free Quantitation of Proteoforms, Proteoform Ratios, and Total Protein up to 80kDa Split across Physiochemical Multidimensional Space – Southwestern Medical Center / University of Texas at Dallas


PRESENTATION: Implementation of a spatial metabolomics approach for exploring interactions within a tripartite plantfungus-cyanobacterium system – EMSL


PRESENTATION: Liquid extraction surface analysis mass spectrometry for protein analysis directly from clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa – University of Birmingham / National Physical Laboratory, Teddington


The expression CMS was featured in the following Advion posters:

POSTER: Delta Ion Current (IC)- A novel approach to plottotal ion currents enhancing the signal from newly detected ions – Authors: Lawrence Klecha, Daniel Mikel, Advion Inc.



POSTER: Identification of an unknown biocide by volatile atmospheric pressure chemical ionization (vAPCI) and compact mass spectrometry (CMS)
– Authors: Daniel Eikel, Simon J. Prosser, Advion Inc.


POSTER: Compact mass spectrometer (CMS) analysis of uniformly 13C-labeled amino acids to identify authentic therapeutic drugs and protect against counterfeits – Authors: Daniel Mikel, Simon J Prosser, Advion, Inc. / Chris Beecher,  IROA Technologies

June 5, 2017

The 65th ASMS Conference on Mass Spectrometry and Allied Topics, June 4-8, Indianapolis

Join us in Indy for the annual ASMS Conference on Mass Spectrometry (MS) and Allied Topics. From posters to short courses, you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #506 during the show to learn more about Advion’s full array of MS tools for chemists.

Read More »
June 2, 2017

The 65th ASMS Conference on Mass Spectrometry and Allied Topics, June 4-8, Indianapolis

Join us in Indy for the annual ASMS Conference on Mass Spectrometry (MS) and Allied Topics. From posters to short courses, you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #506 during the show to learn more about Advion’s full array of MS tools for chemist, including:

  • The TriVersa Nanomate®(TVNM) LESA® with ESI chip® technology

  • The NEW inert atmospheric solids analysis probe (iASAP) for air sensitive compounds

Also, please attend one of our many presentations throughout the week:

  • Saturday June 3 – Sunday June 4, our scientific founder, Jack Henion, will be hosting a 2-day short course (advance registration required) titled “LC-MS: Advanced Techniques & Applications”
  • MP 342 – Monday, June 5, 10:30am – 2:30pm Dr. Daniel Eikel will be presenting a poster titled “Identification of an Unknown Biocide by Volatile Atmospheric Pressure Chemical Ionization (vAPCI) and Compact Mass Spectrometry (CMS)”
  • MP 230 – Monday, June 5, 10:30am – 2:30pm Dr. Simon Prosser will be presenting a poster titled “CMS Analysis of Uniformly 13C-labeled Amino Acids to Identify Authentic Therapeutic Drugs and Protect Against Counterfeits”
  • TP 454 – Tuesday, June 6, 10:30am – 2:30pm Jack Henion will be presenting a poster titled “LC/MS/MS Bioanalytical Protocol for Determining the Degree of Non-Specific Binding in Multi-Well Plates”
  • ThP 429 – Thursday, June 8, 10:30 – 2:30 Lawrence Klecha will be presenting a poster titled “Discovery Ion Current – A Novel Approach to Plot Total Ion Current Real-Time by Enhancing Signal from Newly Detected Ions”

May 18, 2017

The 100th Annual Canadian Chemistry Conference – A Celebration of Chemistry, May 28 – June 1, Toronto

Join us at the Canadian Chemistry Conference for several days’ worth of education, instrumentation news and networking. Our team will be both exhibiting and giving an oral presentation during the event. Visit booth #603 to view the latest advancements in single-quadrupole mass spectrometry.

Read More »
May 18, 2017

The 100th Annual Canadian Chemistry Conference – A Celebration of Chemistry, May 28 – June 1, Toronto

Join us at the Canadian Chemistry Conference for several days’ worth of education, instrumentation news and networking. Our team will be both exhibiting and giving an oral presentation during the event. Visit booth #603 to view the latest advancements in single-quadrupole mass spectrometry, including:

    • The NEW inert atmospheric solids analysis probe (iASAP) for air sensitive compounds

    • The NEW design of the atmospheric solids analysis probe (ASAP) for solvent-free analysis of liquid and solid samples in less than 30 seconds

    • The NEW volatile APCI source for headspace analysis

We also encourage you to join colleague Lee Collier on Tuesday at 8AM for a poster session on the expression CMS in radiochemistry:

Using a Single Quad Mass Spectrometer in a Radiochemistry Lab
TL Collier, Advion Inc., S Liang and N Vasdev, Massachusetts General Hospital, Harvard Medical School

In the last few years the cost of a single quadrupole mass spectrometer (SQMS) has come down substantially and this reduction in price is making SQMS more affordable to researchers in academic settings and is now finding applications in radiochemistry laboratories. Since these SQMS are becoming available to a wider audience, the possible uses of this type of equipment may not be evident to all users.

The user of a SQMS in a simple LC system can provide basic information however, with the addition of some simple equipment – is it possible to improve the sensitivity and utility of the SQMS? In this presentation, we will focus on radiochemistry laboratories and non-traditional applications of SQMS, and how to modify most systems to obtain further information, including: 1? Identification of possible side products, 2) use of fragmentation ion source settings to obtain further structural information, 3) The determination of the parent ion and possible metabolites in plasma samples, 4) The use of a trap and release system to concentrate dilute samples to allow for the determination of molecular ions and metabolites, 5) quantitation and identification of the parent compound in solutions, 6) development of reformulation methodologies using cold standards – at levels that normally seen in PET or SPECT preparations.


For a first look at the iASAP probe, watch our latest product video now:

April 21, 2015

“EASY TO INSTALL, OPERATE, AND MOVE.”

“We have the expression linked to an HPLC instrument and it is used as an open access system. The combination of UV purity data along with MS confirmation is incredibly powerful for our chemists. The instrument is networked so our chemists can then process and review data from their desks.”

Download the customer profile »
April 21, 2015

DYESTUFF ANALYSIS OF CULTURAL HERITAGE OBJECTS by Direct Analysis Probe on a Compact Mass Spectrometer

The scientific investigation of cultural heritage objects is the only access to knowledge about long-gone, ancient societies and their cultural, technological as well as their social  stage of development. In addition, the materials used by our ancestors, e.g. their textiles and the organic dyestuff to colorize these materials, allow researchers to draw some conclusions about cultural exchanges and trading routes. But in-depth knowledge about materials and dyestuff is also of highest importance for proper conservation and restauration of these materials. Specimens, however, are rare and available only in minute amounts. For their investigation preferentially non-destructive or at least minimal invasive methods have to be used.

Download the application note »
April 20, 2015

Compact Mass Spectrometry (CMS) for the Detection and Quantification of Chemical Compounds Related to Cannabis

The cannabinoid makeup of cannabis has significantly changed over the past few decades. Efforts to increase the psychotropic effects of cannabis have resulted in a THC content for current strains of the crop of 30 to 40 percent compared with only 5 percent 30 years ago. Up-regulating the THC content of the plant causes a loss of other cannabinoids the plant is producing. Some of these other cannabinoids, such as CBD, are believed to be responsible for its medical benefits.

Watch the video »
March 22, 2015

Direct Mass Analysis of TLC Plates

Plate ExpressTM is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression® compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

Download the product note »
March 22, 2015

NATURAL PRODUCT ANALYSIS Using Compact Mass Spectrometry with Polarity Switching and In-source CID

Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the  pharmaceutical drug development process and consequently half of all currently approved  drugs in the US are based on natural products. It is therefore not surprising that natural product analysis is a field of major interest world wide. Here, we present a simple example  of the added benefits of mass spectrometry in typical natural product analysis workflows based on an alcoholic extract of nutmeg.

Download the application note »
March 22, 2015

SUZUKI REACTION MONITORING Using Compact Mass Spectrometry with TLC Interface

This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion expression compact mass spectrometer (CMS) and Plate ExpressTM interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination of reaction mixture components without the need for off-line TLC sample preparation procedures.

Download the application note »
March 22, 2015

THC PLANT MATERIAL ANALYSIS Using Compact Mass Spectrometry for Product Control and Law Enforcement of cannabis-related Plant Products

Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible  analysis methods for the detection and quantification of plant  metabolites are required, mass spectrometry is the detector of  choice.

Download the application note »
March 22, 2015

SUDAN DYES ANALYSIS Using Compact Mass Spectrometry with TLC Interface

Sudan Dyes are synthesized azo-dyes which are widely used to generate color in plastics, leather, fabrics, oil, waxes, etc. They are classified as Group 3 carcinogens by the International Agency for Research on Cancer (IARC) and are banned as food additives worldwide. However, in some countries these dyes are still occasionally used in order to intensify the color in products. In this note, a TLC/CMS method using expression compact mass spectrometer (CMS) coupled with the Plate ExpressTM Interface (Advion, Ithaca, NY) is introduced for the detection of 7 Sudan dyes in a chili matrix. The primary advantage of TLC/CMS analysis is the ability to sample directly from the TLC plate without further sample preparation after the TLC separation is done. Molecular weight information of sample components can be determined by the mass spectra from the eluted TLC spots.

Download the application note »