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Introducing the Advion Interchim Scientific SOLATION® ICP-MS

Introduction

The SOLATION® Inductively Coupled Plasma Mass Spectrometer (ICP-MS) puts the power of trace, multi-elemental analysis in your hands by simplifying and optimizing the typical ICP-MS workflow, inside and out. The system offers high performance, multi-elemental analysis, ideal for environmental, clinical, biomedical, food, agriculture, and geological applications.   

The SOLATION® offers a state-of-the-art quadrupole deflector that ensures the analyzer and detector stay clean and improves S/N by preventing neutrals and particles from entering the analyzer. The system is also designed for lower argon consumption. 

Key System Infrastructure Includes:

  • Ion extraction cones: Triple-cone ion extraction, followed by an Einzel lens, which are electrically controlled to maximize transmission of ions into the vacuum system. 
  • RF coil: Plasma generation with water cooled RF coil using industry standard 27 MHz variable frequency generator for rapid impedance matching and ultimate performance with challenging matrices. 
  • Torch: One-piece, demountable torch with fast, one-step connection of argon and ignitor. Optional shield to prevent secondary discharge. 
  • Nebulizer: High efficiency concentric nebulizer available in glass or quartz for compatibility with the widest range of flow rates and sample composition. 
  • Spray chamber: The cyclonic spray chamber with optional temperature control further reduces droplet size and solvent load to ensure stable, efficient plasma. 
  • Peristaltic pump: Integrated 4-channel, 12-roller pump for maximum flexibility and ultra-low pulsation. Software controlled flow rate from 1 μL/min to >1 mL/min. 
  • Gate valve: Allows quick and easy maintenance and replacement of the cones whilst maintaining vacuum integrity. 
  • 90° Quadrupole deflector: Ensures that the analyzer and detector are not in line with the plasma beam, preventing neutrals and particles from entering the analyzer, improving S/N and preventing contamination. 
  • Octupole collision cell: Acts as an ion guide and a collision cell with He gas to provide Kinetic Energy Discrimination (KED) to remove interferences. 
  • Quadrupole Analyzer: High frequency mass filter design with the highest stability to simultaneously maximize transmission, resolution, and abundance sensitivity. 
  • Dual function detectors: Measures in both analog and pulse detection modes with seamless transmission between the two, to allow measurement of high and low levels in a single analysis with more than 9 orders of magnitude of linear dynamic range. 
  • Pulse Detection: captures ions generating pulses shorter than 20 ns; accurate and linear to minimum dwell time of less than 100 μs 
  • Analog Detection: used for higher ion signals while pulse detection is deactivated to extend detector lifetime. 
  • Mass Dependent software control: Software designed to optimize specific mass ranges independently to allow for mass specific tune optimization.  

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Analysis of Heavy Metals in Cannabis using the SOLATION® ICP-MS

Instrumentation: SOLATION® ICP-MS

INTRODUCTION

With the growing acceptance and legalization of hemp and cannabis in the US, Canada, and several other countries, cannabis products are more widely available than ever before. Now approved for medical, recreational and health supplement uses, increased production and consumption have highlighted the need for routine testing and development of testing standards for toxic chemicals, including heavy metals, in cannabis plant material, and all the byproducts made from them, to ensure safe products for the consumer.  With the adoption of chapters <232> and <233>, US Pharmacopeia (USP) specifies a list of elements and maximum exposure limits based on toxicity and routes of administration for pharmaceutical products.  

Many states that have legalized medical and recreational cannabis base their exposure limits on the USP values.  California, Colorado, and Massachusetts are examples with Permissible Daily Exposure (PDE) limits by inhalation for As, Cd, Hg, and Pb. These values are summarized in Table 1. 

Table 1: PDE limits for states that use the USP guidelines for heavy metal exposure by inhalation. USP<233> also defines the accuracy, repeatability, and ruggedness required for the analysis of these toxic elements:

Validation Criteria

Accuracy: The matrix and materials under investigation must be spiked with target elements at concentrations that are 50%, 100%, and 150% of the maximum permitted daily exposure (PDE). Mean spike recoveries for each target element must be within 70%-150% of the actual.

Repeatability: Six independent samples of the material under investigation must be spiked at 100% of the target limits defined and analyzed. The measured percent relative standard deviation (%RSD) must not exceed 20% for each target element.

Ruggedness: Carrying out the repeatability measurement testing procedure by analyzing the six repeatability test solutions either on different days, either with a different instrument or by a different analyst. The %RSD of the 12 replicates must be less than 25% for each target element.

In this study, we used the Advion SOLATION® ICP-MS and a microwave digestion system to digest and analyze hemp samples using the validation methods described in USP General Chapter <233>.  The sensitivity, ability to handle complex matrices, and the ability to remove interferences with a helium collision cell makes this the ideal system for heavy metal analysis in the cannabis industry.

EXPERIMENT

Sample Preparation

A sample of medicinal hemp flower was purchased locally.  Around 14 grams was finely ground and homogenized, then 0.5g +/- 0.005g was weighed into digestion vessels and the appropriate amount of a spike solution added.  Nine mL of concentrated HNO3 and 1 mL concentrated HCl was added to each vessel and the samples were allowed to react for 15 minutes prior to sealing and placing the vessels on the turntable of the closed vessel microwave digestion system.  The program controls the microwave energy such that the samples ramped up to the optimal digestion temperature of 200°C over 20 minutes, maintained 200°C for 10 minutes, and then cooled back to room temperature.  

This method resulted in the complete digestion of all samples resulting in a clear, particulate-free solution once brought to volume with 18MΩ water in a 50mL volumetric flask.

The calibration standards and spikes were based on the action levels in table 1.  The sample set included a hemp sample, a duplicate, the 50%, 100%, and 150% spikes, and NIST 1575 Pine needles to further validate the results, which were run in duplicate.  For the ‘ruggedness’ specification from USP<233>, there were 6 samples of the 100% spiked hemp.  The spike values are summarized in Table 2.

Table 2: Spike values based on the action limits defined in USP<233>

A second, 1:4 dilution was performed post digestion to bring the final acid concentration to 5% for an overall dilution factor of 400x.  The calibration blank and standards were prepared using the same acid concentration, 5% of 9:1 HNO3/HCl, for matrix matching.  To stabilize mercury and help with wash-out, Gold was added at 20x the mercury concentration.  The internal standards were added to all the samples, standards and blank for a final concentration of 10 ng/g (ppb).  The standard concentrations and internal standards are summarized in Table 3.

Table 3: Analyte masses, calibration standards, and internal standards.

Instrumentation

The Advion SOLATION® ICP-MS incorporates a robust solid-state generator, orthogonal ion optics for keeping the most sensitive components of MS clean, and easy-to-use control and data processing software. 

Since HCl was used in the sample digestion, there is a significant amount of chlorine present which creates an isobaric interference on 75As from 40Ar35Cl+.  The collision cell effectively eliminates the contribution that ArCl+ makes to the signal at m/z 75 by taking advantage of kinetic energy discrimination (KED) to separate polyatomic interferences from analyte ions resulting in accurate quantitation of low levels of Arsenic.  Arsenic is the only analyte in the suite with this type of interference, so the collision cell isn’t used for Cd, Hg, or Pb.  

A glass concentric nebulizer fitted to a cyclonic spray chamber, connected to the standard torch with an injector ID of 2mm, was used for sample introduction.  Instrument running parameters are summarized in Table 4.

Table 4: ICP-MS Parameters

RESULTS AND VALIDATION

Sample Results

The concentrations of mercury and lead in hemp were less than the lowest standard and all values were less than the action limits. The samples were prepared and analyzed in duplicate, and the average of those duplicates is shown in Table 5. In keeping with the ruggedness requirement, the samples were run on separate days by two different analysts.

Table 5: Hemp sample results (average of the sample and duplicate)

Accuracy: The samples were spiked at 50%, 100%, and
150% of the action level (Table 2 above) and the percent recoveries calculated. Spike recoveries were all between 92.5% – 114.1%, well within the 70-150% range defined by the USP method.

Table 6: Accuracy- Spike recoveries

Repeatability: Six hemp samples were spiked at 100% of the action level and digested. The results that are summarized in Table 7 show that the %RSD of the measured concentrations are between 1.3% – 3.7%, demonstrating repeatability well below the 20% limit.

Table 7: USP<233> Repeatability results

Ruggedness: The repeatability sample set was prepared and run on a different day by a different analyst. The results from that run are combined with the previous run to determine the ruggedness. The ruggedness values are similar to the repeatability values and the measured %RSD (2.4 – 4.0%) are comfortably under the 25% limit defined by the USP method. The results are summarized in Table 8.

Table 8: USP<233> Ruggedness results

NIST 1575a Results

The results for the NIST SRM are summarized in Table 9. The values for As and Hg were less than
the low standard in solution but there is good agreement between the experimental values and the certified values.

Table 9: NIST 1575a Pine Needles SRM

CONCLUSION

This study demonstrates that the Advion SOLATION® ICP-MS , coupled with a microwave digestion system, is suitable for the accurate, robust and reproducible analysis of heavy metals in hemp plant material – greatly exceeding the requirements of USP <233> protocol.

Validation of the microwave digestion method was reinforced by the excellent recovery results obtained for the NIST SRM 1575 Pine.

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Direct Sample Analysis of Fizzy Drinks Without Sample Preparation on a Compact Mass Spectrometer

Mass Spec: expression® CMS
Sampling: ASAP

INTRODUCTION

Chemists are tasked with quickly identifying compounds created, ensuring quality of products, or evaluating safety. Current techniques are adequate, but not all offer the speed, data quality, or ease-of-use provided by the Advion expression® CMS. The CMS with the Advion ASAP offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.

METHOD

The extended glass capillary of the ASAP was dipped into each fizzy drink sample. The excess was wiped off and the probe was inserted directly into the ASAP-enabled APCI ion source of the CMS, producing results in seconds.

Figure 1: The ASAP containing the sample directly inserted into the ASAP-enabled APCI source of the CMS for analysis.

Figure 2: Schematic of the ASAP sampling probe for APCI-CMS analysis.

RESULTS

SUMMARY

The ASAP/CMS analysis provided data in < 1 min with no sample preparation and no chromatography, making it ideal for reaction monitoring, compound identification, food safety, and analysis of natural products.

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Classifying Cheeses by Volatile APCI (vAPCI) Compact Mass Spectrometry

Mass Spec: expression® CMS
Sampling: vAPCI

INTRODUCTION

Cheese is one of the world’s most popular food types, with a wide variety available for consumers. We commonly eat cheeses from cows, goats, and sheep. The scents and flavors of cheeses, so characteristic to each type of cheese, stem from a complex mixture of chemicals, including free fatty acids. While this mixture is affected by a wide variety of factors we can use the mass spectra to characterize the volatile profiles of different types of cheeses.

Figure 1: (A) Goat cheese, (B) Blue Stilton,  (C) Red Leicester, (D) Wensleydale.
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Figure 2: Schematic of the vAPCI source inlet system.

In this application note, we demonstrate the capability of the Advion expression® CMS to analyze volatile fatty acids of various types of cheeses using our volatile APCI (vAPCI) ion source. By heating the cheese samples, we released various volatile compounds, mainly fatty acids, and analyzed the headspace without any sample preparation or derivatization. We then performed statistical analysis to group the cheese samples by their different volatile profiles.

 

METHODS

Several cheeses of different types were warmed in vessels to 70°C for 2 hours, and the headspaces of the vessels were analyzed using the CMS with a vAPCI ion source, using solvent flow (10 mM4NH4OAc in 1:1 MeOH:H2O) to aid in ionization.

While the cheese samples contained many of the same fatty acids, ions invisible to the naked eye will provide the required information to separate the profiles for each cheese. To look for these differences we performed principle component analysis (PCA) on the mass spectra.

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Figure 3: A selection of fatty acids commonly found in different cheese.

RESULTS AND DISCUSSION

The mass spectra show that a wide variety of fatty acids evolve from each of the cheese samples when warmed (Figure 3). Each cheese sample contained many of the same fatty acids (Table 1).

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Figure 4: Mass spectra of representative samples of four types of cheese: (A) Goat Cheese, (B) Blue Stilton, (C) Red Leicester, and (D) Wensleydale.

Table 1: Fatty acids observed using vAPCI analysis of cheese samples.

PCA is a statistical tool that is used to look for patterns in data. The resulting plot (Figure 6) shows grouping based on how similar or different samples are from each other. By performing PCA on the data from several samples of each type of cheese, we found that the different cheeses indeed can each be grouped together based on their mass spectra allowing rapid identification using vAPCI analysis. For example, the various goat cheeses had statistically similar spectra and are thus grouped together on the PCA plot. This is generally true of each type of cheese.

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Figure 6: PCA of cheese volatile profiles.

The mass spectra of each type of cheese were characteristic; not only were the spectra for cheese samples similar within each type of cheese, but they were substantially different between the different types of cheeses analyzed.

CONCLUSIONS

We used the Advion expression® CMS with a vAPCI ion source to analyze the fatty acids in vapor given off by warmed cheese samples without any additional sample preparation or derivatization. Additionally, we used PCA to show that the spectra of each type of cheese is characteristic to that type of cheese, which allows us to classify the different cheese samples by their type. This would further allow us to identify cheeses by their type using a simple volatile mass spectrometry set up.

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Analysis of Volatile Compounds in the Fermentation of Beer

Mass Spec: expression® CMS
Sampling: vAPCI

INTRODUCTION

The chemical analysis of alcoholic beverages is an important step in quality control, being used to monitor flavour profiles across batches, study chemical changes in the product over time, and identify the source of any problems (e.g. off flavours).

The complex flavour of beer is primarily a result of the ingredients used, the brewing method, and conditions during fermentation, and the analysis of beer throughout this process can be invaluable in monitoring fermentation and establishing the point at which problems occur. Being one of the most widely consumed beverages worldwide, rapid and reliable analytical techniques are essential to keep up with demand and production.

Gas or liquid chromatography-mass spectrometry (GC/MS or LC/MS, respectively) are traditionally utilised for quality control in the spirit and beverage industry; however, these techniques can be relatively time-consuming and not necessarily ideal for rapid, high-throughput analysis.

METHOD

Figure 1: Advion expression® CMS with vAPCI heat transfer line.page2image34676944

Figure 2: Schematic of vAPCI/CMS.

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Aliquots of the homebrew (1 mL) were collected and analysed 12 hours, 4 days, and 14 days into the fermentation process, in addition to mosaic hop leaves (1 g). The homebrew also contained simcoe and citra hops, which were not analysed.

Each aliquot was sealed in a glass vial and heated to 70oC for 10 minutes. The headspace was drawn directly into the CMS by the Venturi Effect of the vAPCI source for analysis. Samples were analysed in positive ion mode over a range of 30-300 m/z, with a scan time of 400 ms.

RESULTS AND DISCUSSION

Figure 3: Mass spectra of homebrew headspace at (A) 12 hours, (B) 4 days, and (C) 14 days) into fermentation.

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There were distinct changes in the overall volatile profile, notably the gradual increase in the m/z 93 ion, likely the protonated ethanol dimer (Figure 3). The concentration of this ion plateaus at the 4 day timepoint, demonstrating fermentation primarily occurred in the first few days.

Figure 4: Mass spectrum of mosaic hops, added 4 days into fermentation.

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The headspace of mosaic hops used in in this homebrew were also analysed. The hops mass spectrum (Figure 4) was dominated by ions at m/z 81, 137 and 273, all of which are common ions associated with terpenes, a class of compounds responsible for many of the aromas and flavours of hops. Many of these compounds are of the same molecular weights and thus further analysis would be required to differentiate and identify these components. Components derived from hops are readily detected in the beer aliquots, particularly after the 4 day timepoint, when additional hops were added.

CONCLUSIONS

This study demonstrates the use of the Advion expression® CMS with vAPCI for the analysis of volatile compounds from the headspace of home-brew beer and hops. The Venturi-assisted interface of the instrument enabled rapid sampling of volatiles, allowing the changing volatile profile of the homebrew to be observed throughout the fermentation process. This simple method would be suitable for fast quality control during alcoholic beverage production.

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Mistletoe: Kiss of Love or Death? Using Thin Layer Chromatography with Compact Mass Spectrometry

Mistletoe

Mass Spec: expression® CMS
Sampling: Plate Express™ 

 In the spirit of the Holiday season and to ensure that mistletoe kisses are enjoyed and are ‘non-toxic’, we employed the Advion Interchim Scientific expression® Compact Mass Spectrometer (CMS) and the Plate Express™ TLC Plate Reader to analyze a commercial Tincture of Mistletoe ethanolic extract to determine whether tyramine is present in the extract of mistletoe. 

INTRODUCTION 

A sprig of mistletoe symbolizes a tradition of romance (Figure 1), and has a legacy of folklore purporting that extracts of mistletoe can cure cancer along with a long list of other reported health benefits. However, mistletoe is also considered lethal. Reputed to be the “kiss of death”, mistletoe is said by some to be so poisonous that humans can be killed if they ingest the leaves or berries. 

Figure 1: The tradition of mistletoe.
Mistletoe

The reported toxicity made us wonder, why or how can vendors sell mistletoe extracts for purposeful human consumption? One species of mistletoe, Viscum, reportedly contains the poisonous alkaloid, tyramine, which can cause blurred vision, nausea, abdominal pain, diarrhea, blood pressure changes, and even death. A search of peer-reviewed scientific literature reveals a dearth of credible analytical support for the presence of tyramine in mistletoe. 

In the spirit of the Holiday season and to ensure that mistletoe kisses are enjoyed and are ‘non-toxic’, we employed the Advion Interchim Scientific TLC/CMS system (Figure 2) to analyze a commercial tincture of Mistletoe ethanolic extract to determine whether tyramine is present in the extract of mistletoe.

Figure 2: Experimental setup of the Advion Interchim Scientific expression® CMS with the Plate Express™ TLC Plate Reader.
CMS and Plate Express
Figure 3: Experimental herbs used.
Mistletoe herb

EXPERIMENTAL 

A tincture of mistletoe was purchased from Indigo Herbs. A small aliquot of this tincture sample was derivatized with dansyl chloride at 50 ºC for 30 min according to well-known procedures[1]. Similarly, an authentic sample of tyramine was derivatized in the same manner to form its dansyl derivative. 

A small aliquot (10 mL) of the standard tyramine dansyl derivative was applied to the outside lanes (Lanes 1 and 4) of a Merck Silica gel G TLC plate. An aliquot of the derivatized tincture of mistletoe was applied to Lane 2 and a derivatized tincture of mistletoe spiked with tyramine dansyl derivative was applied to Lane 3 (Figure 4). 

Figure 4: TLC plate after development and visualization under long wavelength UV light. Lanes 1 and 4: Dansyl derivative of standard tyramine. Lane 2: Dansyl derivative reaction mixture of mistletoe tincture sample. Lane 3: Tincture extract dansyl derivative with standard tyramine dansyl derivative spiked into it. (A) Rf=0.3 for tyramine dansyl derivative. (B) Rf=0.6 for dansyl chloride.
Mistletoe Results

The air-dried TLC plate was developed in an equilibrated solvent tank containing chloroform/ethyl (8/2, v/v) acetate. The developed TLC plate was then viewed under long wavelength UV light to reveal the separated components (Figure 3). The TLC plate was positioned onto the Plate Express™ TLC Plate Reader whereupon each TLC ‘spot’ could be individually analyzed by TLC/CMS. 

With reference to Figure 4, the TLC/CMS analysis readily showed that the Rf 0.3 spots in the two outside lanes (Lanes 1 and 4) produced a mass spectrum with an abundant m/z 371 consistent with the expected protonated molecule of the tyramine dansyl derivative (Figure 5A). The TLC/CMS mass spectra obtained from the spots with an Rf=0.6 observed in Lanes 1 and 4 were consistent with unreacted dansyl chloride with a protonated molecule at m/z 270 (data not shown). TLC/CMS analysis of the spot in lane 2 at Rf=0.3 showed no evidence for the presence of tyramine dansyl derivative (Figure 5B). 

Figure 5: (A) TLC/CMS mass spectrum of standard tyramine dansyl derivative observed at Rf=0.3 in Figure 4 Lane 1. (B) LC/CMS mass spectrum of derivatized tincture of mistletoe observed at Rf=0.3 in Figure 4 Lane 2. 

Mistletoe Spectra

In the absence of TLC/CMS analysis, it would be logical to conclude the spot at Rf=0.3 in lane 2 was due to the presence of tyramine in the mistletoe tincture sample. The Rf=0.3 spot observed for the fortified tincture extract in Lane 3 of Figure 4 readily showed the same mass spectrum for tyramine dansyl derivative that is shown in Figure 5A. The same negative results for tyramine were obtained from the alcohol extract of the mistletoe leaf product. 

CONCLUSIONS 

The results from this brief study suggest either that the level of tyramine in the tincture sample is very low and below our detection limits or that tyramine is not present in the sample. It is common for synthetic and forensic chemists to employ TLC techniques as a quick, easy screen of a sample to determine the presence of an expected chemical. Comparison with a known sample, which shows the same Rf value, will often provide some confidence for reporting the presence of the expected compound. However, as this example suggests a similar Rf value does not guarantee confirmation of the spot identity when it has the same Rf value. As shown here, access to the direct analysis of the spot with the Advion Interchim Scientific expression® CMS can either corroborate the expected identification or, as in this case, suggest that the spot with the same Rf value is NOT the expected compound. These results may explain why the commercial mistletoe tincture samples are not harmful for medicinal purposes. So, what should you do? Mistletoe is not deadly. But it can be hazardous, so don’t eat it. Just ‘steal a kiss under it’! 

REFERENCES AND ACKNOWLEDGEMENT 

[1]Mullins, Donald E. and Eaton, John L. Quantitative high-performance thin-layer chromatography of dansyl derivatives of biogenic amines, Anal. Biochem., 1988, 172, (484-487). 

Thank you to Chief Elf, Nigel Sousou, Ph.D., for leading the sample analysis process. 

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Advion Interchim Scientific Expands Global Footprint with New Offices in Japan, India

ITHACA, N.Y., December 9, 2021 — Advion Interchim Scientific, the market-facing name of a partnership between Advion, Inc. and Interchim SAS, announces two new global centers in Japan and India. To meet market demand, the two new subsidiaries will support instrument and consumable sales and service in these rapidly growing regions, bringing a wide range of flash chromatography, mass spectrometry, and consumables solutions.

“We have the opportunity to work with several of the industry’s brightest minds to create a global channel for the Advion Interchim Scientific line of consumables, accessories, and instruments for flash chromatography, preparative (U)HPLC, analytical (U)HPLC, mass spectrometry, and ICP-MS,” said Dr. Kaveh Kahen, CEO of Advion Interchim Scientific. “With incredible innovation and rapid growth in the Indian and Japanese markets, now is an ideal time to establish subsidiaries in these markets to offer our world-class instrumentation and services.”

In India, Inkarp Instruments PVT LTD., a long-time strategic partner and distributor of Advion Inc, is leading the joint venture “Advion Interchim Scientific Pvt Ltd.,” to create a dynamic offering for the scientific industry combining abundant knowledge and fine reputation of the established Inkarp team paired with the Advion Interchim Scientific range of advanced instrumentation in flash, prep, mass spectrometry and more.

“Inkarp Instruments and Advion Inc. have been partners in India since 2013, and we are delighted to announce our joint venture, Advion Interchim Scientific Pvt Ltd.,” said Natesh Krishnamurthy, CEO of Inkarp, India. “Our goal of bringing world-class chromatography and spectroscopy opportunities to one of the fastest-growing global economies is a strategic move that capitalizes on the Advion Interchim Scientific mission to provide industry-leading identification, quantification, and purification tools on a global scale. With the complete portfolio of products, we will now be able to address a larger market and build on our success with the Advion Interchim Scientific’s Compact Mass Spectrometry systems in India. This joint venture reinforces the strong relationship built over many years of cooperation between our companies.”

In Japan, a direct subsidiary was formed and will provide a dedicated pipeline of instrumentation and consumables to the pharmaceutical and academic segments.

“I look forward to contributing to the growing industry demands in Japan” said Mr. Koji Yokota, General Manager of Advion Interchim Scientific, Japan. “The innovation in Japan is moving at a rapid pace – a pace which the Advion Interchim Scientific suite of systems and consumables will undoubtedly be ready to support.”

For inquiries in Japan, please contact Mr. Koji Yokota, Koji.Yokota@advion-interchim.com. For India, please contact Mr. Vijay Gupta, Vijay.gupta@advion-interchim.com. For all other global inquiries, please contact info@advion-interchim.com.

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About Advion Interchim Scientific:
At Advion Interchim Scientific, we deliver tailored solutions to improve our customers’ most challenging identification, quantification, and purification needs with our broad range of innovative instruments, consumables, reagents, and scientific expertise.

Our unrivaled portfolio ranges from media and columns to consumables, accessories, and instruments for flash chromatography, preparative (U)HPLC, analytical (U)HPLC, mass spectrometry, ICP-MS, coupled with intelligent apps and software.

Strategically aligned for global growth, we recognize that our success has always come from our customers, and we are dedicated and committed to providing best-in-class service and support worldwide.

About Inkarp Instruments:
Inkarp Instruments is one of the top distribution companies in India. It is headquartered in Hyderabad and has regional office covering most regions of India. Inkarp Instruments is continuing to mark its prominence and presence in the analytical instrument market for world class instrument supply, installation and services. Since 1985 the organization has been catering to a very wide range of customers for their requirements of analytical instruments.

For Advion Interchim Scientific:

Kristy Licari
Sr. Director of Marketing
Advion Interchim Scientific
Telephone: 1-607-882-9903
Email: kristy.licari@advion-interchim.com

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Join Advion at the 256th ACS National Fall Conference in Boston, Booth #1908

Join us on the expo floor August 19-21 in Boston, MA for the annual Fall American Chemical Society conference. Here you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques.  Please stop by booth #1908 to learn more about Advion’s full array of MS tools for chemists.

This year, we are hosting a workshop titled, “Mobile Mass Spectrometry: Taking the laboratory to the Field” featuring Dr. Heather Walker of the University of Sheffield Plant Production and Protection team.
Date/Time/Location: Tuesday, August 21, 9:30-10:30a – Room 1 on the Conference Floor
Description: When instant mass analysis became paramount to the Sheffield University Plant Production and Protection (P3) team, they took the laboratory directly to the field utilizing the expression Compact Mass Spectrometer from Advion. The system provides direct sample analysis of liquids, solids and powders and provides mass spectral information within seconds. This enabled the Sheffield team to obtain rapid detection of metabolite markers in plant samples within the field environment, rather than waiting days for results from the lab.

This workshop features the research led by Professor Mike Burrell and Dr. Heather Walker, highlighting how they turned their SUV into a mobile mass spec unit, capable of screening the fields to obtain rapid metabolite analysis of several different varieties of wheat.

“The utilization of this equipment is of huge benefit as it allows the knowledge that we have gained in the laboratory to be transferred and monitored quickly and easily in the field,” said Dr. Walker. “Using this technology can provide higher detail data on crops in the field than previously possible.

 

Looking for more ACS details? Visit the official site for lectures, exhibitors, posters, social events and more!

Background: The American Chemical Society National Meeting takes place in the spring and fall each year, offering the latest in chemistry developments, achievements and awards. The 2018 ACS fall meeting is in Boston, MA, August 19-23. The expo floor where Advion will be located is open August 19-21. We hope to see you at ACS Fall 2018!

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Shotgun Lipidomics Analysis

Infusion based Lipidomics analysis (Shotgun Lipidomics) is an analysis strategy that emerged in the last 15 years and involves the liquid extraction of lipids from samples such as blood, tissue homogenates or dried blood spots. As a next step, the extract will be automatically processed for nano-electrospray nESI followed by targeted or global mass spectrometry detection of lipids in the absence of liquid chromatography.

Shotgun Lipidomic experiments can be designed as relative or absolute quantitative assays utilizing the mass spectrometer intensity data and significant computer processing to investigate changes in e.g free fatty acids by principle component analysis. This approach is suitable for a wide range of biomedical questions of lipid differentiation and lipid flux in the field of metabolic disease, neurological disorders, cancers or eye diseases, to state a few.