New publication: Direct analysis of intact proteins from Escherichia coli colonies by LESA mass spectrometry

Researchers in the UK have demonstrated the use of Liquid Extraction Surface Analysis (LESA) on the TriVersa NanoMate for top-down identification of proteins directly from living bacterial colonies grown in Petri dishes, without sample preparation. The method offers “improved sampling precision and could be useful for spatial profiling of bacterial colonies or analysis of contaminated surfaces.”

Reaction Monitoring by Direct Analysis Probe on a Compact Mass Spectrometer

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile compounds. ASAP is available as a combined ASAP-APCI source, or existing APCI sources can be easily modified to become dual APCI-ASAP capable.

“Everyone can use it, including students.”

Dr. Frédéric Schmidt’s group at the Institut Curie in Paris had previously given their samples to outside MS services for analysis and had to wait for the results. Incorporating Advion’s expression CMS into their lab allowed them to have a self-service option that everyone could use. And the new workflow sped up their process significantly.

Peptide/Protein Analysis in Less than One Minute

The expression CMS is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

Direct Mass Analysis from Solid & Liquid Samples

The expression CMS improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP® (Atomospheric Solids Analysis Probe), to permit chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.