Combined Atomic and Molecular (CAM) Ionization: The Diversity of the Liquid Sampling – Atmospheric Pressure Glow Discharge (LS-APGD) on a Compact Mass Spectrometer

Mass spectrometric techniques are typically divided into two distinct fields: atomic and molecular. Liquid sampling – atmospheric pressure glow discharge (LS-APGD) has been developed as a versatile ionization source capable of combined atomic and molecular (CAM) analysis. To date, the LS-APGD has demonstrated impressive results in U isotope ratio analysis as well as molecular analysis across a wide range of instrument platforms.1-3 While molecular sampling has been demonstrated on this source, these samples fall into the realm of ESI-type samples, larger, polar compounds, most commonly LC-relevant drug targets. Presented here will be the demonstration of the wider versatility of the LS-APGD as a CAM ionization source using the Advion expression Compact Mass Spectrometer (CMS).

Authors: Tyler Williams¹, Jacob R. Bills¹, Jamey Jones², and R. Kenneth Marcus^1
1Clemson University, Department of Chemistry, Clemson, SC 29634
²Advion Inc, Ithaca, NY 14850

This poster was presented at the ASMS 2020 Reboot.