University of Zurich, Zurich, Switzerland
Q: What is the focus of your Lab’s research?
A: To address unresolved questions in DNA chemical biology, our group develops molecular probes for characterizing the structure, function, and dynamics of nucleic acids in vivo. Daily work in our lab relies heavily upon the rational design and synthesis of new organic compounds and their metal-containing complexes.
Q: What Previous WorkfLoW chaLLeNges DiD you exPerieNce?
A: One major challenge to our workflow is the rapid identification of new target molecules that are often prepared as complex mixtures.
Q: Why DiD you iNcorPorate the exPressioN cMs iNto your Laboratory?
A: We chose the expression CMS as a rapid and sensitive screening tool to identify new target molecules from the chromatographic separation of crude reaction mixtures. Given the exceptionally high sensitivity of this system, desired compounds that are initially made in trace quantities can be easily identified.