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Application Note

Toluene-Assisted APCI and Elemental Composition Prediction Using a Compact Mass Spectrometer

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective…

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Application Note

Rapid Screening for Fentanyl in Urine using the Advion expressionL CMS with the Touch Express™ Open Port Sampling Interface (OPSI)

Quick and easy analysis methods for drugs of abuse are in high demand from health practitioners and law enforcement agencies on a global scale. In 2017, it was found that fentanyl, a fast-acting synthetic painkiller that is nearly 100 times stronger than morphine, has become the most widely abused synthetic opioid medicine – to the…

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Poster

Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

 Introduction  Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism.  Although immunoassay…

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Poster

Rapid Screening for Fentanyl in Urine Using a Compact Mass Spectrometer (CMS) with an Open Port Sampling Interface (OPSI)

Introduction Fentanyl, a fast-acting synthetic painkiller about 100 times stronger than morphine, is also the most widely used synthetic opioid medicine in 2017.1 Its abuse is becoming a public health problem. A quick and easy analysis method for this drug is in high demand from health practitioners and law enforcement agencies.  The Touch Express™ Open…

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Poster

Cannabis-related Bioanalysis (from Plant to Forensic) using LC-CMS (Single Quad)

Introduction The legalization of marijuana and hemp provides commercial opportunities as well as analytical challenges. Accurate and precise quantitative analysis of plant and medicinal products is needed in this new industry to document composition and assure the safety of cannabis products. LC/MS techniques can provide unparalleled selective and sensitive measurements for these purposes. Here we…

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Poster

Touline-Assisted APCI Using a Compact Mass Spectrometer (ASMS)

Overview Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ molecules from analytes not MS accessible by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on a compact single quadrupole mass spectrometer (CMS) provides a cost-effective…

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Poster

Monitoring Synthetic Reactions Using an (inert) Atmospheric Solids Analysis Probe (iASAP)

Introduction Metal based compounds have found utility in various fields such as clinical, energy, food safety and environmental to name a few. Creating the metal complex is the last step in a synthetic process when ligands are bound to the metal center. Once made, these metal complexes can be used anywhere from stereospecific synthesis to…

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Product Note

TAMI Molecular Identification Software Suite for expression CMS

Turn your expression CMS into a high resolution, exact mass instrument in its ability to provide elemental formulae. TAMI uses accurate centroiding and mass correction algorithms to provide a more accurate mass assignment.  In combination with isotope abundance analysis and careful consideration of chemical valence rules this provision of elemental formulae with a high level…

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Webinar

University of Leeds Webinar: Self-Optimizing Continuous Flow Reactors

Chemical processes can be performed in two ways; in batch or in flow, each method having set advantages and disadvantages associated with them. Flow chemistry has gathered increasing attention over the past decade and is being readily adopted into academia to help improve synthetic routes, which maybe undesirable in batch, where outputs such as yield,…

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Application Note

LC/CMS Determination of Polycyclic Aromatic Hydrocarbons (PAHS) in Water (EPA 610 Mix)

Polycyclic aromatic hydrocarbons (PAHs) are neutral compounds containing multiple aromatic fused rings that are present in fossil fuels and can be formed from the incomplete combustion of organic material. In recent years, it has been well documented that several PAHs can be potentially carcinogenic via exposure or ingestion. The EPA has classified seven PAHs (benzo[a]pyrene, benz[a]anthracene, chrysene, benzo[b]fluoranthene, benzo[k]fluoranthene, dibenz[a,h]anthracene, and indeno[1,2,3-cd]pyrene) as Group…

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Webinar

Lab Manager Webinar featuring Advion Touch ExpressTM Open Port Sampling Interface (OPSI)

The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression Compact Mass Spectrometer, the product…

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Video

Touch ExpressTM Open Port Sampling Interface (OPSI) – How it Works

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture. Watched the video and ready to learn more? View More Touch Express Details

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Application Note

Direct Analysis of Intact Proteins using the Advion Touch Express© Open Port Sampling Interface (OPSI) with the expressionL Compact Mass Spectrometer

Touch ExpressTM is a new sampling device for mass spec analysis using a technique developed by Gary Van Berkel and Vilmos Kertesz of Oak Ridge National Laboratory – the Open Port Sample Interface (OPSI). This fast, versatile sample inlet paired with the expression Compact Mass Spectrometer (CMS) provides simple molecular weight determination of surfaces, solids and liquids in < 30s.

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