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Video

TriVersa NanoMate with LESA Plus Liquid Extraction Surface Analysis PLUS LC

Learn more about Liquid Extraction Surface Analysis PLUS LC separation with the Advion TriVersa NanoMate featuring new LESAPlus technology.

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Brochure

TriVersa NanoMate® LESA® with ESI chip® technology

The TriVersa NanoMate® LESA® is the latest in chip-based electrospray ionization technology from Advion. It combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection and direct surface analysis into one integrated ion source platform. It allows scientists to obtain more information from complex samples than LC/MS alone.

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Publication

Liquid Extraction Surface Analysis Mass Spectrometry Method for Identifying the Presence and Severity of Nonalcoholic Fatty Liver Disease

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Application Note

Shotgun Lipidomics Analysis

Infusion based lipidomics analysis (shotgun Lipidomics) is an analysis strategy that involves the liquid extraction of lipids from samples such as blood, tissue homogenates or dried blood spots. This approach is suitable for a wide range of biomedical questions of lipid differentiation and lipid flux in the field of metabolic disease, neurological disorders, cancers or eye…

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Application Note

Microorganism Surface Analysis Using the TriVersa NanoMate for Liquid Extraction Surface Analysis of Bacteria and Fungi

Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) has been utilized for determination of small molecules, lipids and proteins from a variety of surfaces such as tissue sections, plant material, medical devices, TLC plates or DBS cards. It allows direct surface analysis without sample preparation from spot sizes of 1 mm diameter by aspiration of extraction…

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Video

LESA PLUS Liquid Extraction Surface Analysis PLUS LC Seperation

The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation.

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Application Note

Pesticides from Food Surfaces Using LESA PLUS Liquid Extraction Surface Analysis PLUS LC Separation

Residues and contaminants in the food chain are an increasing problem due to high production volumes, large area distribution and import/export of food items across the world. The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation. This combination is ideally suited…

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Product Note

LESA Plus: Liquid Extraction Surface Analysis PLUS LC Separation

The Liquid Extraction Surface Analysis (LESA) capability of the TriVersa NanoMate enables simple, direct nanoESI mass spectrometric analysis from a variety of surfaces. The new LESAPLUS allows for automated LESA experiments plus additional nano-LC separation through the ChipSoftX operating software with Developers Kit. This enhancement is ideal for direct tissue analysis.

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Product Note

CHIPSOFT 10.0 WITH DEVELOPERS KIT: Customized method development for the TriVersa Nanomate

ChipSoftX is an entirely new operating software for the TriVersa NanoMate automated nanoelectrospray source. Besides improvement in program compatibility with Windows and integration of existing software features, it also provides access to the new Developers Kit – a platform for customized method development with direct access to robot controls allowing entirely novel analysis workflows such…

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University of Southern Denmark

"Essential for any Lipidomics Laboratory."

Christer S. Ejsing, PhD, Associate Professor

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Application Note

Using the TriVersa NanoMate with LESA for Analyte Profiling in Material Science

Surface analysis techniques have gained significant attention over the last couple of years with LESA being an interesting alternative to techniques such as SIMS or MALDI imaging. This note demonstrates practical applications for LESA in the material sciences.

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University of Birmingham

"The TriVersa NanoMate revolutionized nanospray."

Dr. Helen Cooper, Senior Lecturer, School of BioSciences

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Max Planck Institute of Molecular Plant Physiology Golm, Germany

"I can’t imagine running these analyses without the TriVersa NanoMate"

Dr. Patrick Giavalisco, Research Group Leader

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School of Chemistry, University of Bristol – Bristol, UK

"Advion’s technology gives you what you want very quickly."

John Crosby, Senior Lecturer, Organic & Biological Chemistry

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Institute for Research in Biomedicine – Barcelona, Spain

"If I could, I would have a TriVersa NanoMate on all of our mass spectrometers."

Marta Vilaseca, PhD, Mass Spectrometry Core Facility Manager

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Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Germany

"We have built our lab around the TriVersa NanoMate."

Dr. Andrej Shevchenko, Research Group Leader

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Max Planck Institute for Chemical Ecology – Jena, Germany

"You purchase the TriVersa NanoMate for one purpose, but it allows you to develop many applications."

Dr. Aleš Svatoš, Research Group Leader

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Product Note

Protein-Ligand Interactions Using the TriVersa NanoMate®

Nozzle-to-nozzle reproducibility enables the rapid determination of dissociation constants (Kd). Download this product note to find out how.

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Product Note

Protein Identification Using the TriVersa NanoMate(TM) System Following 2-D Gel Separation

Automated Nanoelectrospray for Proteomics Advion BioSciences, Inc. (Ithaca, NY) has demonstrated use of the NanoMate(TM) 100 system for protein identification from excised two-dimensional gel spots. The NanoMate 100 is an automated sample-handling system coupled with the ESI Chip™ (a 10 x 10 array of nano-electrospray nozzles etched in silicon).

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Product Note

Protein Identification Using the TriVersa NanoMate®

Obtain an ID in 6 minutes per sample. Download this product note to find out how.

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Product Note

Metabolite Identification Using the TriVersa NanoMate®

Greater than 10 times more sensitive than LC/MS/MS for detection of low level, potentially active or toxic recirculating metabolites.

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Product Note

Lipid Profiling Using the TriVersa NanoMate®

Fast, reproducible, and automated lipid analysis using chip-based nanoelectrospray infusion

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Product Note

LESA – Liquid Extraction Surface Analysis

More analytes and higher sensitivity Developed in collaboration with Oak Ridge National Laboratory*, the liquid extraction surface analysis (LESA) capability of the TriVersa Nanomate® enables simple, direct ESI mass spectrometric analysis from a variety of surfaces.

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Product Note

Glycosylation Research Using the TriVersa NanoMate®

Fully characterize oligosaccharides that are missed by LC/MS/MS. Download this product note to find out how.

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Product Note

FTMS/ECD Analysis with the TriVersa NanoMate®

Don’t compromise resolution, mass accuracy and sensitivity. Download this product note to find out how.

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Webinar

The Latest in Liquid Extraction Surface Analysis – LESA Clarity for AB SCIEX Mass Spec Systems

Presented by: Dr. Tom Covey In this web presentation Dr. Tom Covey describes how researchers can incorporate the fast, simple & direct method of LESA Clarity for AB SCIEX Mass Spec Systems into their labs. He shows data that illustrates how you can see more analytes with better sensitivity.

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Webinar

Profiling Complex Mixtures Using a TriVersa NanoMate Assisted SYNAPT G2 Hybrid QTof Ion-Mobility Mass Spectrometry

Presented by: John P. Shockcor, Director of Life Sciences Business Development, Waters Corp., Visiting Fellow, Dept. of Biochemistry, University of Cambridge, UK Description: Profiling low level components in a complex mixture of small molecules can be a challenging task. Although it may be possible to detect many low level components in a complex mixture, characterization…

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Webinar

Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) Novel Profiling Tool for Drug Distribution & Metabolism Analysis

Presented by: Dr. Daniel Eikel, Sr. Application Scientist – Advion, Inc. Description: Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel mass spectrometry-based surface-profiling technique (Kertez, et al., 2009) that can be utilized in drug distribution and metabolism studies. Potential advantages of LESA-MS are as follows: No radiolabeled compound is required Its overall sensitivity…

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Webinar

LESA™ – Liquid Extraction Surface Analysis: A New Surface Analysis Technique Using the Advion TriVersa NanoMate

Presented by: Thomas Covey, Principal Research Scientist at AB SCIEX Thomas Covey describes how various organizations are incorporating the fast, simple, and direct method of LESA – Liquid Extraction Surface Analysis – into their labs. He shows data that illustrates how you can see more analytes with better sensitivity by combining LESA with mass spectrometry…

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Webinar

Automation of Multidimensional Mass Spectrometry-based Shotgun Lipidomics

In this webinar, Dr. Han describes how he uses the TriVersa NanoMate’s chip-based nanoelectrospray ionization capabilities in infusion mode to obtain more information from complex samples and faster lipids analysis with no sample-to-sample carryover. The interests of Dr. Han’s laboratory have been focused on the altered lipid metabolism, trafficking, and homeostasis under patho(physio)logical conditions. Currently,…

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Webinar

HRMS, Chemical Modification and Liquid Extraction Surface Analysis for Lipidome Profiling of Colon Adenocarcinom

Presented by: Gavin Reid, Associate Professor at Michigan State University A large number of studies have demonstrated that disruption of lipid metabolism or signaling pathways can play a key role in the onset and progression of human disease, including cancer and diabetes. Thus, a comparative analysis of changes in individual lipids or lipid profiles (i.e.,…

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Webinar

Integrated Top-down/Bottom-up Proteomics for the Characterization of Protein Isoforms

Presented by: Ljiljana Paša-Tolić, Ph.D., Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory Description: Obtaining extended sequence coverage of intact proteins and characterizing multiple post-translational modification (PTM) sites can pose key technical challenges. In this webinar, we describe how we have implemented Advion’s TriVersa NanoMate® and RePlay® technologies to address these issues using an integrated…

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Publication

Deciphering drift time measurements from travelling wave ion mobility spectrometry-mass spectrometry studies

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Product Note

TriVersa NanoMate: The System for Post-Translational Modifications (PTMs)

Fully characterize PTM’s missed by LC/MS/MS. Download this product note to find out how.

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