Resource Center

 

Publication

Liquid Extraction Surface Analysis Mass Spectrometry Method for Identifying the Presence and Severity of Nonalcoholic Fatty Liver Disease

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Application Note

Shotgun Lipidomics Analysis

Infusion based lipidomics analysis (shotgun Lipidomics) is an analysis strategy that involves the liquid extraction of lipids from samples such as blood, tissue homogenates or dried blood spots. This approach is suitable for a wide range of biomedical questions of lipid differentiation and lipid flux in the field of metabolic disease, neurological disorders, cancers or eye…

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Customer Profile

University of Cambridge, Ley Group

“I would recommend the system to any group that works with continuous flow chemistry, especially those that need real time analysis of stream compositions.”

Daniel E. Fitzpatrick, Ph. D Candidate, Student Researcher & Founder, ChemInventory

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Video

vAPCI: How it Works

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.

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Video

iASAP: How it Works

The inert Atmospheric Solids Analysis Probe (iASAP) allows easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glovebox or Schlenk line.

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Video

ASAP: How it Works

Advion’s direct atmospheric solids analysis probe, otherwise known as ASAP, permits chemists fast and reliable sample analysis of liquid and solid samples such as reaction mixtures, food samples, natural products and tablets.

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Video

Plate Express: How it Works

Advion’s Plate Express is ideal for fast, easy TLC/MS analysis. Coupled with the expression compact mass spectrometer, the TLC plate reader allows prep-free sampling and data in less than 30 seconds.

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Product Note

Gas Phase Sample Analysis By Volatile APCI (vAPCI)

Volatile Atmospheric Pressure Chemical Ionization (vAPCI) combined with Advion’s expression® compact mass spectrometer (CMS) is a fast and easy method to analyze the headspace of a sample with no additional sample prep. The vAPCI ion source is a simple, powerful tool for gas phase sample analysis. The technique can quickly and confidently identify compounds in…

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Product Note

Quant Express – Mass Express 4.0 Software with Quantitation

Quant Express, an addition to Advion’s user-friendly Mass Express 4.0 software suite, features quantitation to create a fully integrated software system for expression CMS users.

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Product Note

iASAP – Mass Analysis of Air-Sensitive Samples Without Sample Prep

The Atmospheric Solids Analysis Probe (ASAP™) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallic, from reactions that are carried out in a glove…

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Product Note

Atmospheric Solids Analysis Probe for Direct Mass Analysis of Liquid & Solid Samples

Advion’s direct atmospheric solids analysis probe, otherwise known as ASAP, permits chemists fast and reliable sample analysis of liquid and solid samples such as reaction mixtures, food samples, natural products and tablets. Chemists simply dip the closed end of a glass capillary into the sample of interest (even complex mixtures) or scrape the surface of…

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Research Analyst – University of Leiden

“I incorporated the expression CMS as a TLC/MS system because of its simplicity, low cost and the brilliant combination with the Plate Express.”

Dr. Hans van den Elst, Research Analyst, University of Leiden

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Department of Chemistry – Creighton University

“It’s easy, walk-up use with straightforward swapping of ESI and APCI sources make it a reliable, productive tool for determining synthetic success.”

Dr. Martin Hulce, Department of Chemistry, Creighton University

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Application Note

Microorganism Surface Analysis Using the TriVersa NanoMate for Liquid Extraction Surface Analysis of Bacteria and Fungi

Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) has been utilized for determination of small molecules, lipids and proteins from a variety of surfaces such as tissue sections, plant material, medical devices, TLC plates or DBS cards. It allows direct surface analysis without sample preparation from spot sizes of 1 mm diameter by aspiration of extraction…

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Webinar

The Role of Mass Spectrometry in the Drug Discovery Unit’s Workflow – Medicinal Chemistry & the Advion CMS

This webinar examines the workflow of a medicinal chemist as they utilize compact mass spectrometry techniques for drug discovery and disease prevention.

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Video

LESA PLUS Liquid Extraction Surface Analysis PLUS LC Seperation

The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation.

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Application Note

Chemically Tracking Spoilage of Meat Using Vapor Mass Spectrometry

This application note demonstrates the use of the Advion expression CMS (compact mass spectrometer) coupled with a vapor APCI (vAPCI) ion source to directly detect several key chemicals given off of meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured over several days as meat spoiled.

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Application Note

Identification of a Pesticide Used in Lawn Care by vAPCI Compact Mass Spectrometry

At regular intervals throughout the year a local lawn service applies pesticides to the lawn surrounding the Advion headquarters in Ithaca, NY. The grass is very uniform and not a single dandelion or crabgrass plant is visible – so we wondered, what chemical do they use? After an application in the early spring, we sampled…

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Application Note

Analyses of Different Grades of Olive Oil by Volatile Mass Spectrometry

In this application note, we demonstrate the use of the Advion expression CMS with a volatile APCI (vAPCI) ion source to analyze extra-virgin, virgin, and lampante olive oil samples. We show statistical analysis allowing us to categorize and identify olive oil samples by their grade. This technique allows us to test individual olive oil samples and…

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Application Note

Classifying Cheeses by vAPCI Compact Mass Spectrometry

Cheese is one of the world’s most popular food types, with a wide variety available for consumers. The scents and flavors of cheeses, so characteristic to each type of cheese, stem from a complex mixture of chemicals, including free fatty acids. While this mixture is affected by a wide variety of factors we can use…

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Application Note

Sudan Dyes Analysis Using Compact Mass Spectrometry with TLC Interface

Sudan Dyes are synthesized azo-dyes which are widely used to generate color in plastics, leather, fabrics, oil, waxes, etc. They are classified as Group 3 carcinogens by the International Agency for Research on Cancer (IARC) and are banned as food additives worldwide. However, in some countries these dyes are still occasionally used in order to…

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Application Note

Screening of Dietary Supplements by ASAP® Compact Mass Spectrometry

In this application note, we demonstrate the use of the Advion expressionL CMS with an atmospheric solids analysis probe (ASAP) ion source to analyze two supplements (figure 1) that contain DMBA, a synthetic stimulant that has not been tested on humans. The substance is the chemical cousin to drug DBAA, which is currently banned by…

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Presentation

Liquid Extraction Surface Analysis (LESA) combined with Nano-liquid chromatography mass spectrometry (nLC/MS) for analyte determination from biological surfaces

The new Liquid Extraction Surface Analysis (LESA) mode of the TriVersa NanoMate can now be combined with nano liquid chromatography and a smaller extraction drop size of 400 µm to result in a powerful novel surface analysis mode. Resulting in the detection of small molecule drugs from tissue sections, residue on plant material or lipid…

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Application Note

Pesticides from Food Surfaces Using LESA PLUS Liquid Extraction Surface Analysis PLUS LC Separation

Residues and contaminants in the food chain are an increasing problem due to high production volumes, large area distribution and import/export of food items across the world. The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation. This combination is ideally suited…

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Application Note

Lipid Species from Brain Tissue Sections Using LESA PLUS Liquid Extraction Surface Analysis PLUS LC Separation

Spatial lipid composition, distribution and regulation are very important factors for mediating lipid functionality and, when disrupted, can cause pathophysiological processes leading to cancer, obesity, atherosclerosis, and neurodegeneration. The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation. This combination is ideally…

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Presentation

Application of Mass Spectrometry in Small Molecule Medicinal Chemistry in an Academic Lab

The Montclair University team utilizes the Advion CMS in their undergraduate lab. Essential in the research-focused curriculum, the team was able to purchase the cost effective, small-footprint system to grow their lab capabilities. They later added an APCI module for their growing needs.

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Presentation

Real-time and near real-time Volatile Organic Compound (VOC) Analysis by vAPCI- Compact Mass Spectrometry

The Loughborough University team has utilized the expression CMS vAPCI source for a variety of applications including breath analysis, monitoring flavor and fragrance, plant metabolomics, food authenticity and spoilage, and microbiological monitoring. With the use of the expression CMS, the team was able to successfully execute detection required for these applications quickly and easily.

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Presentation

A Medicinal Chemist’s View on using the Advion CMS

Explore how the expression CMS has been used by the Drug Discovery Unit at the University of Dundee. Learn how the medical chemistry team has integrated the instrument in to their everyday workflow. The team required a system with a small footprint that can be moved between labs, but was still capable of integrating with systems in their…

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Product Note

Study of Ionization Efficiency on Silicon-Based, Micro-Fabricated Electrospray Nozzles For Micro Flow LC-ESI-MS Applications

The coupling of reduced liquid chromatography (LC) flow rates with electrospray ionization (ESI) provides enhanced sensitivity and ionization efficiency, and reduced ion suppression in mass spectrometry analysis. As the LC flow increases, the ionization efficiency drops owing to the larger sized droplets that lowers the number of available charges per analyze molecule. In order to accommodate micro-flow rates (defined as 1-10μL/min), we have developed a silicon-based ESI chip with various I.D. sizes (4.1, 5.5, 9.5, and 13.5μm).

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Poster

Study of ionization efficiency on silicon-based, micro-fabricated electrospray nozzles for micro flow LC/ESI-MS applications

One of the benefits of nanoelecrtospray ionization (nanoESI) is the reported optimal ionization efficiency (equalized response) of chemically different analyses despite the presence of matrix components. However, outside of a very low flow rate of ca. 1-20 nL/min, the ionization efficiency drops exponentially and coupling higher flow rates from a typical liquid chromatography (LC) system…

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Publication

Compact mass spectrometry in modern SPPS

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Cyclotron and Radiochemistry Research Program – UNC School of Medicine

“The convenience of having a mass spectrometer in our laboratory means that we can increase working efficiencies.”

Dr. Zibo Li, Department of Radiology UNC School of Medicine

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Department for Homogeneous Catalysis, Max-Planck-Institut für Kohlenforschung

“Rapid characterization of reaction products combined with the lowest effort of sample preparation”

List Research Group, Max-Planck-Institut für Kohlenforschung

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Application Note

Chemically Tracking Spoilage of Meat Using Vapor Mass Spectrometry

This application note demonstrates the use of the Advion expression CMS (compact mass spectrometer) coupled with a vapor APCI (vAPCI) ion source to directly detect several key chemicals given off of meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured  over several days as meat spoiled.

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Application Note

Protein analysis via LC/CMS with automated charge state deconvolution

The Advion deconvolution algorithm employs a combination of predictive charge envelope generation, overlap calculation with actual MS data acquired utilizing a maximum entropy goodness of fit approach followed by artifact removal through determination of peak significance. This novel approach allows for a rapid deconvolution over a wide mass range in seconds. It also allows a…

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Center for Free-Electron Laser Science (CFEL), Hamburg, Germany

"We are able to follow the process of most of our reactions which greatly facilitates our research."

Dr. Marta Sans, Research group of Prof. Dr. Arwen Pearson

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Albert-Ludwigs-University, Freiburg, Germany

"We can now analyse highly air sensitive compounds without difficulty and outside a glove box."

Prof. Dr. Ingo Krossing, Institute for Inorganic and Analytical Chemistry

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University of Ljubljana, Slovenia

"We recommend this to every medicinal chemistry department."

Dr. Janez Ilaš, Associate Professor, The Chair of Pharmaceutical Chemistry, Faculty of Pharmacy

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Polish Academy of Sciences

"Instant feedback about the reaction progress and aid in isolation of the product saves a lot of time."

Prof. Dr. Janusz Jurczak, Stereo-controlled Organic Synthesis and Supramolecular Chemistry, Institute of Organic Chemistry

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SYNKOLA Ltd., Bratislava, Slovakia

"We recommend the purchase of the expression CMS to all organic and synthetic chemists groups for its ease of use."

Dr. Roman Fisera, Executive Member

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University of Hull

"A cost effective way to introduce practical LCMS studies to the undergraduate laboratory class."

Kevin Welham, Department of Chemistry

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Poster

Compact Mass Spectrometry (CMS) for Reaction Monitoring and Quality Control of Modern Solid Phase Peptide Synthesis (SPPS)

A recent development in mass spectrometry is the design of smaller sized MS systems with full analytical capability (compact mass spectrometry, CMS). CMS systems with fragmentation analysis are very cost effective analysis solutions and ideally suited for reaction and quality control in SPPS including detailed product characterization3. Here, we evaluate the utility of a system…

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Application Note

LC/MS Screening For EDTA In Fresh Blood Swabs Using the Advion expression CMS System

This application note suggests that a simple LC/MS screen of a relatively fresh sample of human whole blood collected from a lavender capped potassium EDTA anticoagulant blood sample applied to a cotton swab can be analyzed by full-scan positive ion or negative ion LC/MS using a compact single quadrupole mass spectrometer (expression CMS).

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Application Note

Complete Reaction-Monitoring Solution

Reaction monitoring is a key aspect in a range of chemistry environments from chemical synthesis to drug discovery to understanding natural products and protein synthesis. To understand the optimal time to quench a reaction for maximum yield as well as to monitor a reaction real-time is vital to many medicinal and synthetic organic chemists. The…

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Product Note

’TIDES EXPRESS – A Fast, Affordable Proteins & Peptides Analysis System

The ’tides express combines an extended mass range, compact mass spectrometer (expression L CMS) with an easy-to-use HPLC gradient system with manual sample injector for rapid, real-time analysis of large molecules at the point-of-need.

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Application Note

LC/CMS Determination of Polycyclic Aromatic Hydrocarbons (PAHs) in Water (EPA 610 mix)

Changtong Hao, Ph.D. – Advion, Inc. This application note will demonstrate the LC/MS determination of 16 PAHs (EPA 610 Mix) in the EPA priority target list using the Advion expression Compact Mass Spectrometer (CMS) coupled to an Agilent 1220 Liquid Chromatography (LC) system. The detection limits for the 16 PAHs in a water matrix were…

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Application Note

Qualitative Analysis of Commonly Abused Drugs by LC/MS on the expression CMS

D. Tranchemontagne, N. Sousou, S. J. Prosser, J.D. Henion – Advion, Inc. & S. Orlowicz, S. Sadjadi, L. Snow – PhenoLogix The Advion expression CMS (compact mass spectrometer) coupled with Liquid Chromatography (LC) was used as a qualitative screening tool. This application note will demonstrate the screening of various drugs, including amphetamines, benzodiazepines, antidepressants, opiates…

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Product Note

CheMS

The CheMS user interface simplifies the mass spectrometry experience and makes it more accessible in chemistry and biochemistry laboratories. This allows the chemist to obtain optimal data without needing to be an expert in mass spectrometry.

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Product Note

LESA Plus: Liquid Extraction Surface Analysis PLUS LC Separation

The Liquid Extraction Surface Analysis (LESA) capability of the TriVersa NanoMate enables simple, direct nanoESI mass spectrometric analysis from a variety of surfaces. The new LESAPLUS allows for automated LESA experiments plus additional nano-LC separation through the ChipSoftX operating software with Developers Kit. This enhancement is ideal for direct tissue analysis.

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Product Note

CHIPSOFT 10.0 WITH DEVELOPERS KIT: Customized method development for the TriVersa Nanomate

ChipSoftX is an entirely new operating software for the TriVersa NanoMate automated nanoelectrospray source. Besides improvement in program compatibility with Windows and integration of existing software features, it also provides access to the new Developers Kit – a platform for customized method development with direct access to robot controls allowing entirely novel analysis workflows such…

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Application Note

Mistletoe: Kiss of Love or Death?

Using Thin-Layer Chromatography with Compact Mass Spectrometry A sprig of mistletoe symbolizes a tradition of romance; however, reputed to be the “kiss of  death,” mistletoe is said by some to be so poisonous that humans can be killed if they  ingest the leaves or berries. In the spirit of the Holiday season and to ensure…

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University of North Carolina at Pembroke

"Well suited for a variety of undergraduate curricular and research lab applications."

Paul Anthony Flowers, Professor of Chemistry

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Presentation

Microfluidic Labeling of Peptides, Proteins and Antibodies

NanoTek users have successfully radiolabeled a variety of biological compounds using the following isotopes: 18F, 64Cu, 68Ga, 89Zr, 90Y, 99mTc, 111In and 211At.

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John Innes Centre

"The Advion Plate Express™ is used as a faster alternative."

Rob Field, Ph.D., Professor of Chemistry & Biochemistry

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Application Note

To Catch the Candy Thief: Who stole my chocolate?

An office colleague has stolen a prized chocolate bar, and Dr. Eikel with the help of his partner, Dr. Henion, use an ASAP enabled expression CMS to determine whodunnit. This application note describes the process, and points the finger at the guilty culprit!

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Application Note

Flow Chemistry Monitoring & Optimization Using Compact Mass Spectrometry

This note covers work carried out at Leeds University with co-workers from Durham University in the area of flow chemical synthesis using the expression CMS (Advion, Ithaca, NY). Two different reactions are described.

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Poster

Development of an Interface for the Analysis of Volatiles Using a Portable Mass Spectrometer

P. P. Hurtado1, E., Palmer1, C. Aldcroft2, H. Moore2, A. Baker2. M. Allen2, J. Jones2, M.A. Turner1, J.C. Reynolds1 1Centre for Analytical Science, Department of Chemistry, Loughborough University, Ashby Road, Loughborough, Leicester, LE11 3TU, UK 2Advion UK Ltd The development of new interfaces that enable direct analysis of VOCs represents an attractive and low cost…

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Liverpool School of Tropical Medicine

"You do not need to be an expert in mass spectrometry to generate very useful and meaningful data."

Sitthivut Charoensutthivarakul

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Application Note

Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS

Co-authored with Merck Millipore in Darmstadt, Germany, this application note provides an example of TLC/CMS (thin-layer chromatography-compact mass spectrometry) for the determination of 4-aminobiphenyl in its reaction mixture.

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Application Note

Analysis of 4-Aminobiphenyl and 4-Bromoanilin on reversed phase TLC using TLC/MS

Co-authored with Merck Millipore in Darmstadt, Germany, this application note demonstrates a TLC/CMS (thin-layer chromatography-compact mass spectrometry) technique for the rapid determination of 4-aminobiphenyl in its reaction mixture.

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University of Hull

"The expression CMS has undoubtedly saved our group a great deal of time and has advanced our research."

Rhiannon Lee, Ph.D., Department of Chemistry and Positron Emission Tomography Research Centre

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Application Note

Recommendations for Transferring Peptide Mapping Methods to LC/MS Using Core-Shell Columns

With the emergence of new protein therapeutics, including biosimilars, biobetters and ADCs, peptide mapping by LC/MS is becoming more commonly used for the identification of post-translational modifications (PTMs), glycosylation, and conjugation sites, as well as primary sequence confirmation. The purpose of this study is to provide guidelines for developing optimal LC running conditions with Aeris™…

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University of Dundee

"Easy to install, operate, and move."

Margaret Huggett, Medicinal Chemist, Drug Discovery Unit

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SynZeal Research Pvt Ltd, Ahmedabad, Gujarat, India

"I recommend expression CMS as an affordable alternative for mass analysis."

Dr. Jitendra Kaila, PhD, Director

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Application Note

Real-Time Reaction Monitoring of a Solution-Phase Peptide Synthesis using the PlateExpress and expression TLC/CMS

Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions in the modern laboratory.  Peptides of pharmaceutical  interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected…

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Brochure

Mass Spec for Teaching Brochure

Developed for chemistry students  to gain industry-relevant mass spectrometry skills. Advion offers a plug and play, compact, single quadrupole mass spectrometer designed specifically with the academic chemistry laboratory in mind. When teaching undergraduates the basics of chemistry, it is important to keep the spark of learning alive. The expression CMS takes learning to a new…

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Application Note

Dyestuff Analysis of Cultural Heritage Objects by Direct Analysis Probe on a Compact Mass Spectrometer

The scientific investigation of cultural heritage objects is the only access to knowledge about long-gone, ancient societies and their cultural, technological as well as their social  stage of development. In addition, the materials used by our ancestors, e.g. their textiles and the organic dyestuff to colorize these materials, allow researchers to draw some conclusions about…

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Webinar

Compact Mass Spectrometry (CMS) for the Detection and Quantification of Chemical Compounds Related to Cannabis

This webinar examines three different workflows surrounding compact mass spectrometry as they apply to cannabis law enforcement, it’s natural product research, and product control.

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Product Note

Direct Mass Analysis of TLC Plates

Plate ExpressTM is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression® compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

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Application Note

Sudan Dyes Analysis Using Compact Mass Spectrometry with TLC Interface

Sudan Dyes are synthesized azo-dyes which are widely used to generate color in plastics, leather, fabrics, oil, waxes, etc. They are classified as Group 3 carcinogens by the International Agency for Research on Cancer (IARC) and are banned as food additives worldwide. However, in some countries these dyes are still occasionally used in order to…

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Application Note

Suzuki Reaction Monitoring Using Compact Mass Spectrometry with TLC Interface

This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion expression compact mass spectrometer (CMS) and Plate ExpressTM interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination of reaction…

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Application Note

Natural Product Analysis Using Compact Mass Spectrometry with Polarity Switching and In-source CID

Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the  pharmaceutical drug development process and consequently half of all currently approved  drugs in the US are based on…

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Application Note

THC Plant Material Analysis Using Compact Mass Spectrometry for Product Control and Law Enforcement of cannabis-related Plant Products

Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible  analysis methods for the detection and quantification…

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Brochure

expression CMS: Compact. Fast. Easy. & Affordable

With over 20 years of mass spectrometry and chemistry expertise, Advion has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting.

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Application Note

Screening of explosives residues without sample preparation using a direct sample analysis probe on the expression CMS

The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to…

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Application Note

Direct Sample Analysis: Detecting THC/Cannabinoids in Contraband by Compact Mass Spectrometry

This is an expanded application note with more data regarding direct sample analysis of THC in suspected contraband and on skin. Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec)…

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Application Note

Direct Sample Analysis: Detecting THC/Cannabinoids in Contraband by Compact Mass Spectrometry

Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.

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Application Note

Direct Sample Analysis of “Fizzy Drinks”

The expression CMS with the direct analysis probe offers chemists the ability to rapidly analyze solids, liquids and powders without tedious and time consuming sample preparation.

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Application Note

LC/MS Determination of Amino Acids Using Compact Mass Spectrometry

A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.

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University of Southern Denmark

"Essential for any Lipidomics Laboratory."

Christer S. Ejsing, PhD, Associate Professor

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Application Note

Using the TriVersa NanoMate with LESA for Analyte Profiling in Material Science

Surface analysis techniques have gained significant attention over the last couple of years with LESA being an interesting alternative to techniques such as SIMS or MALDI imaging. This note demonstrates practical applications for LESA in the material sciences.

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University of Birmingham

"The TriVersa NanoMate revolutionized nanospray."

Dr. Helen Cooper, Senior Lecturer, School of BioSciences

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Video

Direct Analysis of Liquids and Solids

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture.

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Application Note

Environmental Analysis

Quantitation of Perchlorate by Ion Chromatography with Suppressed Conductivity on the expression CMS Perchlorate is a synthetic chemical that is used in the manufacture of rocket fuel, fireworks, flares and explosives, and can also be present in bleaches and some fertilizers [1]. The EPA has devised drinking water regulations for Perchlorate to minimize its impact…

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Application Note

Analysis of Two Reaction Products by Direct Analysis Probe on a Compact Mass Spectrometer

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, low cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile…

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Application Note

Reaction Monitoring by Direct Analysis Probe on a Compact Mass Spectrometer

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile…

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University of Loughborough

"Anyone interested in volatiles will find the CMS is an excellent instrument for targeted analysis."

James Reynolds, PhD, Research Scientist

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Application Note

Protein Analysis

Via Manual Injection using a Compact Mass Spectrometer with extended mass range (CMS-L) The CMS-L is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — ideal for large molecule applications such as the analysis of proteins. Its small foot print makes it the…

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Application Note

LC/MS Analysis of Proteins

Using the expression CMS-L compact mass spectrometer The CMS-L is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — well-suited for large molecule applications such as the analysis of proteins. Its small foot print makes it the instrument of choice for space restricted…

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Product Note

Direct Mass Analysis from Solid & Liquid Samples

The expression CMS provides essential information quickly and improves the chemist’s workflow by using a direct analysis probe, otherwise known as ASAP® (Atomospheric Solids Analysis Probe) permits chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.

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Reach Separations, United Kingdom

"The expression CMS is an excellent all round instrument that meets our needs perfectly"

Peter Ridgway, Business Development Director

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Helmholtz-Center Dresden-Rossendorf

"PhD students appreciate the ‘in-time’ information about success or failure when developing novel compounds"

Dr. Holger Stephan, Group Leader, Nanoscalic Systems

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Boston College

"I would highly recommend the purchase of the expression CMS, especially to core labs or any small college looking for a well-made easy to use system."

Marek A. Domin MSc, MRSC, CChem, CSci, Director of Mass Spectrometry

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MRC Human Nutrition Research

"The CMS is a rugged instrument."

Albert Koulman, PhD, Senior Investigator Scientist

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Institut Curie, Paris

"Everyone can use it, including students."

Frédéric Schmidt, PhD, Senior Scientist, Group Leader

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Application Note

Ambient Ionization

Compact Mass Spectrometry for Fast, Quantitative VOC Screening Breath analysis is a valuable and widely-used technique that is gaining popularity in medical diagnostics, sports science, substance abuse and other fields where immediate, reliable detection of a variety of in-vivo compounds and their metabolites is required. However, the actual analysis can be complicated because of the type of…

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Poster

Determination of Emerging Nitrogenous Economic Adulterants in Milk Proteins by HPLC/Compact Mass Spectrometry

Economic adulteration of milk involves adulteration with nitrogen-rich compounds to interfere with the widely used Kjeldahl protein assay and inate the total protein content result for economic gains. The economic adulteration issue garnered global attention during the melamine scandal in 2007 which resulted in the sickening and deaths of infants fed with adulterated milk powder.…

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Beijing Institute of Technology

"The CMS is a very helpful instrument that has shorten product detection times."

Zihui Meng, Professor

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Presentation

Utilizing a novel compact mass spectrometer (CMS) for the detection and quantification of chemical compounds related to cannabis

Regardless of the legal status of cannabis and its chemical compounds, both the quality control in legal markets as well as the law enforcement of it’s illegal status require simple, unequivocal and legally defendable analysis methods for the detection and quantification of its major chemical compounds. Whenever a detector of high selectivity and sensitivity is…

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Max Planck Institute of Molecular Plant Physiology Golm, Germany

"I can’t imagine running these analyses without the TriVersa NanoMate"

Dr. Patrick Giavalisco, Research Group Leader

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School of Chemistry, University of Bristol – Bristol, UK

"Advion’s technology gives you what you want very quickly."

John Crosby, Senior Lecturer, Organic & Biological Chemistry

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Institute for Research in Biomedicine – Barcelona, Spain

"If I could, I would have a TriVersa NanoMate on all of our mass spectrometers."

Marta Vilaseca, PhD, Mass Spectrometry Core Facility Manager

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Max Planck Institute of Molecular Cell Biology and Genetics Dresden, Germany

"We have built our lab around the TriVersa NanoMate."

Dr. Andrej Shevchenko, Research Group Leader

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Max Planck Institute for Chemical Ecology – Jena, Germany

"You purchase the TriVersa NanoMate for one purpose, but it allows you to develop many applications."

Dr. Aleš Svatoš, Research Group Leader

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Vanderbilt University, Institute of Imaging Science, Nashville, TN

"Establish in one day what traditionally takes weeks."

H. Charles Manning, Ph.D., Director of Molecular Imaging Research

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Poster

Electrospray LC/MS response differences from equimolar quantities of drugs using a compact mass spectrometer equipped with atmospheric pressure ionization

The purpose of this study was to evaluate the positive and negative electrospray (ESI) and atmospheric pressure chemical ionization (APCI) LC/MS ion current response from a representative synthetic mixture of standard pharmaceutical compounds. The selected drup compounds were prepared as an equimolar mixture and analyzed by an optimized gradient LC/MS procedure using a novel compact…

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University of Zurich, Zurich, Switzerland

"I recommend the expression CMS to all laboratories that routinely synthesize new small molecules."

Prof. Dr. Nathan Luedtke, Associate Professor of Chemical Biology, Institute of Organic Chemistry

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Product Note

Protein-Ligand Interactions Using the TriVersa NanoMate®

Nozzle-to-nozzle reproducibility enables the rapid determination of dissociation constants (Kd). Download this product note to find out how.

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Product Note

Protein Identification Using the TriVersa NanoMate(TM) System Following 2-D Gel Separation

Automated Nanoelectrospray for Proteomics Advion BioSciences, Inc. (Ithaca, NY) has demonstrated use of the NanoMate(TM) 100 system for protein identification from excised two-dimensional gel spots. The NanoMate 100 is an automated sample-handling system coupled with the ESI Chip™ (a 10 x 10 array of nano-electrospray nozzles etched in silicon).

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Product Note

Protein Identification Using the TriVersa NanoMate®

Obtain an ID in 6 minutes per sample. Download this product note to find out how.

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Product Note

Metabolite Identification Using the TriVersa NanoMate®

Greater than 10 times more sensitive than LC/MS/MS for detection of low level, potentially active or toxic recirculating metabolites.

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Application Note

Sequential Back-to-Back Preparation of Two Radiotracers from One Delivery of 18F

The NanoTek Microfluidic Synthesis System provides a flexible platform for offering dual benefits of high efficiency and fast synthesis. This application note describes how the NanoTek system can be configured for the sequential back-to-back preparation of two different radiotracers from one delivery of [18F]fluoride.

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Product Note

Lipid Profiling Using the TriVersa NanoMate®

Fast, reproducible, and automated lipid analysis using chip-based nanoelectrospray infusion

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Product Note

LESA – Liquid Extraction Surface Analysis

More analytes and higher sensitivity Developed in collaboration with Oak Ridge National Laboratory*, the liquid extraction surface analysis (LESA) capability of the TriVersa Nanomate® enables simple, direct ESI mass spectrometric analysis from a variety of surfaces.

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Product Note

Glycosylation Research Using the TriVersa NanoMate®

Fully characterize oligosaccharides that are missed by LC/MS/MS. Download this product note to find out how.

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Product Note

FTMS/ECD Analysis with the TriVersa NanoMate®

Don’t compromise resolution, mass accuracy and sensitivity. Download this product note to find out how.

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Product Note

Chip-Mate

Robust & reliable nano-LC ion source The Chip-Mate is a nan0-electrospray ion source that uses the ESI Chip® technology and couples it to a nano-LC column. The proven ESI Chip performance along with automated spray sensing and next nozzle switching capabilities improves the sample analysis workflow and reduces the number of failed nano-LC runs. Download…

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Montclair State University

"The expression CMS is easily serviceable by a non-expert."

David Rotella, PhD, Professor, Chemistry & Biochemistry

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Merck KGaA and Merck Millipore

"The CMS has shortened product development times allowing us to deliver quickly valuable applications for new products."

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Application Note

Peptide/Protein Analysis in Less than One Minute

The expression compact mass spectrometer (CMS) is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

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Application Note

Protein Analysis Using Compact Mass Spectrometry

The expression compact mass spectrometer (CMS) is a high performance, easy to use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other systems, the CMS brings the analytical benefits of mass spectrometry to more scientists than ever before.

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Webinar

The Latest in Liquid Extraction Surface Analysis – LESA Clarity for AB SCIEX Mass Spec Systems

Presented by: Dr. Tom Covey In this web presentation Dr. Tom Covey describes how researchers can incorporate the fast, simple & direct method of LESA Clarity for AB SCIEX Mass Spec Systems into their labs. He shows data that illustrates how you can see more analytes with better sensitivity.

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Webinar

Profiling Complex Mixtures Using a TriVersa NanoMate Assisted SYNAPT G2 Hybrid QTof Ion-Mobility Mass Spectrometry

Presented by: John P. Shockcor, Director of Life Sciences Business Development, Waters Corp., Visiting Fellow, Dept. of Biochemistry, University of Cambridge, UK Description: Profiling low level components in a complex mixture of small molecules can be a challenging task. Although it may be possible to detect many low level components in a complex mixture, characterization…

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Webinar

Nano-LCMS in Routine Bioanalysis Application to Human NGF Biomarker Studies

Presented by: Gary A. Schultz, Ph.D., Senior Director, Biomarkers, Advion BioServices, Inc. The number of monoclonal antibodies under development as therapeutic agents has risen significantly. Tracking the concentration profile of the total target biomarker during therapy provides an important contribution to understanding the pharmacokinetic/ pharmacodynamic relationship This presentation highlights the performance of an immunoaffinity nanoLC-MS/MS…

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Webinar

Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) Novel Profiling Tool for Drug Distribution & Metabolism Analysis

Presented by: Dr. Daniel Eikel, Sr. Application Scientist – Advion, Inc. Description: Liquid extraction surface analysis mass spectrometry (LESA-MS) is a novel mass spectrometry-based surface-profiling technique (Kertez, et al., 2009) that can be utilized in drug distribution and metabolism studies. Potential advantages of LESA-MS are as follows: No radiolabeled compound is required Its overall sensitivity…

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Webinar

LESA™ – Liquid Extraction Surface Analysis: A New Surface Analysis Technique Using the Advion TriVersa NanoMate

Presented by: Thomas Covey, Principal Research Scientist at AB SCIEX Thomas Covey describes how various organizations are incorporating the fast, simple, and direct method of LESA – Liquid Extraction Surface Analysis – into their labs. He shows data that illustrates how you can see more analytes with better sensitivity by combining LESA with mass spectrometry…

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Webinar

Automation of Multidimensional Mass Spectrometry-based Shotgun Lipidomics

In this webinar, Dr. Han describes how he uses the TriVersa NanoMate’s chip-based nanoelectrospray ionization capabilities in infusion mode to obtain more information from complex samples and faster lipids analysis with no sample-to-sample carryover. The interests of Dr. Han’s laboratory have been focused on the altered lipid metabolism, trafficking, and homeostasis under patho(physio)logical conditions. Currently,…

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Webinar

HRMS, Chemical Modification and Liquid Extraction Surface Analysis for Lipidome Profiling of Colon Adenocarcinom

Presented by: Gavin Reid, Associate Professor at Michigan State University A large number of studies have demonstrated that disruption of lipid metabolism or signaling pathways can play a key role in the onset and progression of human disease, including cancer and diabetes. Thus, a comparative analysis of changes in individual lipids or lipid profiles (i.e.,…

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Webinar

Developing Photochemical Methods in Flow

Despite the potential to achieve novel and interesting chemical transformations through highly reactive photo-excited substrates, photochemistry still remains largely underutilized by the organic chemistry community. One reason for this is the difficulty in achieving sufficient control of wavelength, UV penetration, and reaction temperature in photochemical reactions. This presentation will highlight photochemistry in flow to overcome…

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Virginia Tech

"There is no substitute for having a mass spectrometer a few steps away from your bench."

John Matson, PhD, Assistant Professor

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Application Note

Routine detection and identification of PET radiopharmaceuticals

The rapid identification of radiolabeled compounds would clearly be beneficial for applied clinical and preclinical tracers used for imaging with positron emission tomography (PET). The limited uptake of mass spectrometry in the imaging field has been due to several factors including concerns regarding adequate sensitivity, instrument footprint in the highly constrained space requirements for the…

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Application Note

Improved efficiency and faster answers — Compact mass spectrometry and U(H)PLC

Ultra (high) performance liquid chromatography (UPLC/UHPLC) is a relatively new technique, and is valued for its speed, efficiency and the quality of information provided. Many synthetic and medicinal chemistry laboratories are moving to this process to improve their workflows and save time.

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Application Note

Real Time Reaction Monitoring of a Solution Phase Peptide Synthesis

Real-time reaction monitoring based on the expression compact mass spectrometer (CMS) can support the synthetic chemist to overcome synthesis challenges and optimize the reaction time on-line. Peptides of pharmaceutical interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected amino acid building blocks 1. A simple model for such…

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Application Note

Mass Directed Fraction Collection

The Advion expression Compact Mass Spectrometer (CMS) was coupled to a Normal Phase Flash Chromatography system for mass directed fraction collection. Typically a UV detector is used to monitor compounds eluting from Normal Phase columns. A limitation of the UV detector is that it relies on compounds having a chromophore in the chemical structure, hence…

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Webinar

Integrated Top-down/Bottom-up Proteomics for the Characterization of Protein Isoforms

Presented by: Ljiljana Paša-Tolić, Ph.D., Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory Description: Obtaining extended sequence coverage of intact proteins and characterizing multiple post-translational modification (PTM) sites can pose key technical challenges. In this webinar, we describe how we have implemented Advion’s TriVersa NanoMate® and RePlay® technologies to address these issues using an integrated…

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Poster

Advantages in sensitivity and robustness for nLC

Advantages of nanoelectrospray ionization (nESI) are primarily the higher ionization efficiency and the direct interfacing with nano liquid chromatography (nLC), which itself offers significant sensitivity gains when coupled to mass spectrometry (MS). However, nLC-nESI-MS is perceived as difficult to handle, less reliable and robust than LC-ESI-MS and hence is still primarily a research tool for…

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Northeastern State University, Tahlequah, Oklahoma

"Our students no longer wait a month for results."

Jessica Martin , PhD, Associate Professor, Chemistry

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Poster

Ready when and where you need it

The expression compact mass spectrometer (CMS) was developed based on decades of chemistry and mass spectrometry experience specifically to meet the needs of chemists.  Many chemists are asked to perform their work in the field, and the CMS was built to be versatile. It is available with a TACOM-compliant Mobile Attenuation Mounting (MAM) system.  This…

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Max-Planck-Institute for Coal Research, Mülheim an der Ruhr, Germany

"An easy to operate, robust and reliable mass spectrometer"

Dr. Roberto Rinaldi, Group Leader Heterogeneous Catalysis, Biomass and Coal

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Application Note

Simple, high-performance coupling of SFC to CMS for mass-directed fraction collection

Recently, Advion co-authored with a major pharmaceutical partner to create two application notes highlighting the benefits of supercritical fluid chromatography (SFC) coupled to a compact mass spectrometer for mass directed fraction collection.  The application notes conclude that mass‐directed fraction collection with a simplified passive splitter on the Preparative JASCO SFC coupled with expression CMS system…

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Product Note

Ultimate in Analytical Flexibility. Multi-Mode expression CMS

The expression CMS was developed with the chemist’s objectives and laboratory workflow in mind. Organic, Natural Product and Peptide chemists utilize many techniques to determine the progress, yield and purity of their reactions.

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Product Note

expression – a versatile (U)HPLC detector with Clarity software

Clarity software from DataApex now supports the expression CMS line of mass spectrometers to provide full integration to a broad range of LC and Prep-LC systems. Many chemists focus on one area of research but operate several platforms and utilize different workflows.

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Product Note

Prep scale SFC/CMS Interface – passive split

Supercritical fluid chromatography (SFC) is a fast growing technique. Initially used almost exclusively for only thermally labile and chiral compounds it is now becoming accepted as a versatile analytical technique applied across a broad range of compounds. It is faster and higher-throughput than regular HPLC and Preparative LC and becoming popular as a ‘green’ technique, with far lower solvent…

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Poster

Application with Mass Directed Preparative SFC Utilizing the JASCO Preparative SFC platform and Advion expression Compact Mass Spectrometer

In this study we evaluated the performance of a Preparative SFC‐MS system combining the JASCO Preparative SFC with the Advion expression CMS (Compact Mass Spectrometer) utilizing a simplified passive splitter for mass‐directed fraction collection. The initial test explored a wide range of flow rates both isocratic and gradient to test performance and reliability of the…

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Product Note

Integration with Agilent Technologies’ (U)HPLC Liquid Chromatography Systems

The expression CMS was designed by expert mass spectroscopists and chemists to create the ideal platform for scientists to get the most out of their research. Full integration (control, data acquisition, and analysis) with Agilent Technologies’ LC systems allows users a streamlined approach for their LC/CMS methods.

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Poster

Ion Chromatography Determination of Inorganic Anions Coupled With the Advion Compact Mass Spectrometer (CMS)

There is a concerted effort by regulatory bodies, such as the EPA to reduce the exposure of environmental contaminants, such as inorganic anions to humans and the environment. Achieving lower analytical detection limits of hazardous compounds in environmental matrices such as water, soils and sediments allows regulatory bodies to make better informed decisions on the…

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Poster

Mass spectrometry guided purification for efficient isolation of natural products at semi- and preparative scale

In natural product research the isolation of compounds from crude extracts is a key element. An increase in the efficiency of the purification process, by improvement of instrumental and methodological approaches, remains a crucial point. In this respect, modern flash chromatography, has evolved and uses 15 μm spherical particles for efficient separation at moderate pressures.…

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Presentation

Positive Ion APCI LC/MS Analysis of Enlite Herbicides

There must be better ways to do sample preparation for food matrices! And with good sample prep better analyses occur. It is human nature to resist change. Let us embrace new ways of doing things if they can be shown to be better, faster and easier.

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Poster

Real-Time monitoring of a Suzuki reaction utilizing a hood-based compact mass spectrometer

A novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions. Medical chemists are routinely faced with personally over a hundred new chemical entities (NCE’s) each year for testing as future pharmaceutical drug candidates. The goal is to prepare a high yield, relatively pure product via an optimized synthetic route.

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Application Note

Real-time monitoring of Suzuki reaction using compact mass spectrometry via LC/MS and flow injection (FI)/MS

Advion demonstrates a novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions employing either LC/MS or flow injection (FIA).

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Publication

Synthesis of 13N-labelled radiotracers by using microfluidic technology

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Product Note

TriVersa NanoMate: The System for Post-Translational Modifications (PTMs)

Fully characterize PTM’s missed by LC/MS/MS. Download this product note to find out how.

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