Resource Center

 

Application Note

Toluene-Assisted APCI and Elemental Composition Prediction Using a Compact Mass Spectrometer

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective…

Learn More »

Application Note

iASAP Analysis of Air-Sensitive Compounds via Inert Sampling Techniques

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®)…

Learn More »

Application Note

Flow Chemistry Monitoring & Optimization Using Compact Mass Spectrometry

This note covers work carried out at Leeds University with co-workers from Durham University in the area of flow chemical synthesis using the expression CMS (Advion, Ithaca, NY). Two different reactions are described.

Learn More »

Application Note

Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS

Co-authored with Merck Millipore in Darmstadt, Germany, this application note provides an example of TLC/CMS (thin-layer chromatography-compact mass spectrometry) for the determination of 4-aminobiphenyl in its reaction mixture.

Learn More »

Application Note

Analysis of 4-Aminobiphenyl and 4-Bromoanilin on reversed phase TLC using TLC/MS

Co-authored with Merck Millipore in Darmstadt, Germany, this application note demonstrates a TLC/CMS (thin-layer chromatography-compact mass spectrometry) technique for the rapid determination of 4-aminobiphenyl in its reaction mixture.

Learn More »

Application Note

Real-Time Reaction Monitoring of a Solution-Phase Peptide Synthesis using the PlateExpress and expression TLC/CMS

Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions in the modern laboratory.  Peptides of pharmaceutical  interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected…

Learn More »

Application Note

Suzuki Reaction Monitoring Using Compact Mass Spectrometry with TLC Interface

This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion expression compact mass spectrometer (CMS) and Plate ExpressTM interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination of reaction…

Learn More »

Application Note

Analysis of Two Reaction Products by Direct Analysis Probe on a Compact Mass Spectrometer

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, low cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile and semivolatile…

Learn More »

Application Note

Reaction Monitoring by Direct Analysis Probe on a Compact Mass Spectrometer

The expression CMS provides essential compound information quickly and improves the chemist’s workflow. The Atmospheric Solids Analysis Probe (ASAP®) permits fast analysis of solid and liquid samples and is a simple, faster and lower cost alternative to LC/MS methods. This direct analysis probe method has been shown to be useful for the analysis of volatile…

Learn More »

Application Note

Real-time monitoring of Suzuki reaction using compact mass spectrometry via LC/MS and flow injection analysis (FIA)/MS

Advion demonstrates a novel compact single quadrupole mass spectrometer for hood-based applications in the analysis of chemical reactions employing either LC/MS or flow injection analysis (FIA).

Learn More »