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Brochure

Plate Express: Direct Mass Analysis from TLC Plates

Provides simple, automated MS analysis in seconds, directly from TLC plates The Plate Express is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique, chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

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Brochure

AVANT HPLC & (U)HPLC Chromatography Systems

Providing simple, high-performance, LC/CMS with the expression CMS Modular, stackable design, with many options provides custom solutions for both HPLC and UHPLC needs. From the simplest manual injection HPLC to a fully automated, streamlined UHPLC system and everything in-between, the Avant series can be configured to fit your analytical requirements and your budget. The AVANT…

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Brochure

Touch Express Open Port Sampling Interface

For One-Touch Mass Analysis of Solids, Liquids, Surfaces and Fibers with the expression CMS  The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of surfaces, solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. …

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Poster

Direct Analysis of Intact Proteins Using the Advion Touch Express™ Open Port Sampling Interface (OPSI) with the Advion expressionL Compact Mass Spectrometer

Introduction Electrospray mass spectrometry (ESI-MS) is a versatile analytical tool for biomolecular protein analysis and proteomics. One important area is to study protein structure and composition in which peptides and proteins can be ionized with multiple charges via electrospray ionization. Based on the charge envelope, the molecular weight can be easily determined using manual or…

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Webinar

Webinar featuring Advion Touch ExpressTM Open Port Sampling Interface (OPSI)

The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression Compact Mass Spectrometer, the product…

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Video

Touch ExpressTM Open Port Sampling Interface (OPSI) – How it Works

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture. Watched the video and ready to learn more? View More Touch Express Details

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Product Note

Touch ExpressTM Open Port Sampling Interface (OPSI) – Direct analysis of solids, liquids, surfaces and fibers with the expression CMS

The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression Compact Mass Spectrometer, the product…

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Webinar

Peptide-Based Materials for Controlled Delivery of Hydrogen Sulfide

Shared live at the 254th ACS National Meeting in Washington, D.C. – John Matson, Ph. D., Matson Research Group on Macromolecular and Supramolecular Chemistry, Assistant Professor, Virginia Tech. Listen to the recorded workshop session highlighting the role of H2S in the human body and how compact mass spectrometry is used to assay peptides via direct injection for reaction…

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Poster

Compact mass spectrometer (CMS) analysis of uniformly 13C-labeled amino acids to identify authentic therapeutic drugs and protect against counterfeits

Cost effective, multidimensional GRAS (generally recognized as safe) counterfeit protection of drugs based on uniformly 13C labeled amino acids with compact mass spectrometry detection.

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Video

Plate Express: How it Works

Advion’s Plate Express is ideal for fast, easy TLC/MS analysis. Coupled with the expression compact mass spectrometer, the TLC plate reader allows prep-free sampling and data in less than 30 seconds.

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Application Note

Protein analysis via LC/CMS with automated charge state deconvolution

The Advion deconvolution algorithm employs a combination of predictive charge envelope generation, overlap calculation with actual MS data acquired utilizing a maximum entropy goodness of fit approach followed by artifact removal through determination of peak significance. This novel approach allows for a rapid deconvolution over a wide mass range in seconds. It also allows a…

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Poster

Compact Mass Spectrometry (CMS) for Reaction Monitoring and Quality Control of Modern Solid Phase Peptide Synthesis (SPPS)

A recent development in mass spectrometry is the design of smaller sized MS systems with full analytical capability (compact mass spectrometry, CMS). CMS systems with fragmentation analysis are very cost effective analysis solutions and ideally suited for reaction and quality control in SPPS including detailed product characterization3. Here, we evaluate the utility of a system…

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Application Note

Complete Reaction-Monitoring Solution

Reaction monitoring is a key aspect in a range of chemistry environments from chemical synthesis to drug discovery to understanding natural products and protein synthesis. To understand the optimal time to quench a reaction for maximum yield as well as to monitor a reaction real-time is vital to many medicinal and synthetic organic chemists. The…

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Product Note

’TIDES EXPRESS – A Fast, Affordable Proteins & Peptides Analysis System

The ’tides express combines an extended mass range, compact mass spectrometer (expression L CMS) with an easy-to-use HPLC gradient system with manual sample injector for rapid, real-time analysis of large molecules at the point-of-need.

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Application Note

Recommendations for Transferring Peptide Mapping Methods to LC/MS Using Core-Shell Columns

With the emergence of new protein therapeutics, including biosimilars, biobetters and ADCs, peptide mapping by LC/MS is becoming more commonly used for the identification of post-translational modifications (PTMs), glycosylation, and conjugation sites, as well as primary sequence confirmation. The purpose of this study is to provide guidelines for developing optimal LC running conditions with Aeris™…

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Application Note

Real-Time Reaction Monitoring of a Solution-Phase Peptide Synthesis using the PlateExpress and expression TLC/CMS

Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions in the modern laboratory.  Peptides of pharmaceutical  interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected…

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Brochure

Mass Spec for Teaching Brochure

Developed for chemistry students  to gain industry-relevant mass spectrometry skills, Advion offers a plug and play, compact, single quadrupole mass spectrometer designed specifically with the academic chemistry laboratory in mind. When teaching undergraduates the basics of chemistry, it is important to keep the spark of learning alive. The expression CMS takes learning to a new…

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Application Note

LC/MS Determination of Amino Acids Using Compact Mass Spectrometry

A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.

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Application Note

Protein Analysis

Via Manual Injection using a Compact Mass Spectrometer with extended mass range (CMS-L) The CMS-L is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — ideal for large molecule applications such as the analysis of proteins. Its small foot print makes it the…

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Application Note

LC/MS Analysis of Proteins

Using the expression CMS-L compact mass spectrometer The CMS-L is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — well-suited for large molecule applications such as the analysis of proteins. Its small foot print makes it the instrument of choice for space restricted…

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Application Note

Peptide/Protein Analysis in Less than One Minute

The expression compact mass spectrometer (CMS) is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

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Application Note

Protein Analysis Using Compact Mass Spectrometry

The expression compact mass spectrometer (CMS) is a high performance, easy to use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other systems, the CMS brings the analytical benefits of mass spectrometry to more scientists than ever before.

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Virginia Tech

"There is no substitute for having a mass spectrometer a few steps away from your bench."

John Matson, PhD, Assistant Professor

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Application Note

Real Time Reaction Monitoring of a Solution Phase Peptide Synthesis

Real-time reaction monitoring based on the expression compact mass spectrometer (CMS) can support the synthetic chemist to overcome synthesis challenges and optimize the reaction time on-line. Peptides of pharmaceutical interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected amino acid building blocks 1. A simple model for such…

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