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Brochure

Plate Express: Direct Mass Analysis from TLC Plates

Provides simple, automated MS analysis in seconds, directly from TLC plates The Plate Express is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique, chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.

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Brochure

AVANT HPLC & (U)HPLC Chromatography Systems

Providing simple, high-performance, LC/CMS with the expression CMS Modular, stackable design, with many options provides custom solutions for both HPLC and UHPLC needs. From the simplest manual injection HPLC to a fully automated, streamlined UHPLC system and everything in-between, the Avant series can be configured to fit your analytical requirements and your budget. The AVANT…

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Brochure

Touch Express Open Port Sampling Interface

For One-Touch Mass Analysis of Solids, Liquids, Surfaces and Fibers with the expression CMS  The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of surfaces, solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. …

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Poster

Direct Analysis of Intact Proteins Using the Advion Touch Express™ Open Port Sampling Interface (OPSI) with the Advion expressionL Compact Mass Spectrometer

Introduction Electrospray mass spectrometry (ESI-MS) is a versatile analytical tool for biomolecular protein analysis and proteomics. One important area is to study protein structure and composition in which peptides and proteins can be ionized with multiple charges via electrospray ionization. Based on the charge envelope, the molecular weight can be easily determined using manual or…

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ETH, Laboratory of Organic Chemistry, Zurich, Switzerland

“The expression CMS allows us to efficiently analyze the mass of newly formed compounds in (almost) real time.”

Wennemers Research Group

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Webinar

Webinar featuring Advion Touch ExpressTM Open Port Sampling Interface (OPSI)

The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression Compact Mass Spectrometer, the product…

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Video

Touch Express™ Open Port Sampling Interface (OPSI) – How it Works

Direct sample analysis of liquids, solids and powders without chromatography is as easy as it sounds, and provides mass spectral information within seconds. The video demonstrates analysis of a reaction mixture. Watched the video and ready to learn more? View More Touch Express Details

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Application Note

Direct Analysis of Intact Proteins using the Advion Touch Express© Open Port Sampling Interface (OPSI) with the expressionL Compact Mass Spectrometer

Touch ExpressTM is a new sampling device for mass spec analysis using a technique developed by Gary Van Berkel and Vilmos Kertesz of Oak Ridge National Laboratory – the Open Port Sample Interface (OPSI). This fast, versatile sample inlet paired with the expression Compact Mass Spectrometer (CMS) provides simple molecular weight determination of surfaces, solids and liquids in < 30s.

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Product Note

Touch ExpressTM Open Port Sampling Interface (OPSI) – Direct analysis of solids, liquids, surfaces and fibers with the expression CMS

The Touch ExpressTM Open Port Sampling Interface (OPSI), is designed for simple sampling of solids, liquids and sample preparation tips and fibers. The novel ambient sampling technique was developed by Gary Van Berkel and Vilmos Kertesz, of Oak Ridge National Laboratory. Paired with the electrospray ion source of the expression Compact Mass Spectrometer, the product…

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Customer Profile

Technical University Munich, Garching, Germany

“The expression CMS is the perfect MS system for any research laboratory involved in synthetic organic chemistry and chemical analytics or small molecules to proteins.”

Dr. Tobias A.M. Gulder, Professor

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Webinar

Peptide-Based Materials for Controlled Delivery of Hydrogen Sulfide

Shared live at the 254th ACS National Meeting in Washington, D.C. – John Matson, Ph. D., Matson Research Group on Macromolecular and Supramolecular Chemistry, Assistant Professor, Virginia Tech. Listen to the recorded workshop session highlighting the role of H2S in the human body and how compact mass spectrometry is used to assay peptides via direct injection for reaction…

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Poster

Compact mass spectrometer (CMS) analysis of uniformly 13C-labeled amino acids to identify authentic therapeutic drugs and protect against counterfeits

Cost effective, multidimensional GRAS (generally recognized as safe) counterfeit protection of drugs based on uniformly 13C labeled amino acids with compact mass spectrometry detection.

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Video

ASAP: How it Works

Advion’s direct atmospheric solids analysis probe, otherwise known as ASAP, permits chemists fast and reliable sample analysis of liquid and solid samples such as reaction mixtures, food samples, natural products and tablets.

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Video

Plate Express™: How it Works

Advion’s Plate Express is ideal for fast, easy TLC/MS analysis. Coupled with the expression compact mass spectrometer, the TLC plate reader allows prep-free sampling and data in less than 30 seconds.

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Creighton University, Department of Chemistry

“It’s easy, walk-up use with straightforward swapping of ESI and APCI sources make it a reliable, productive tool for determining synthetic success.”

Dr. Martin Hulce, Department of Chemistry, Creighton University

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Application Note

Protein analysis via LC/CMS with automated charge state deconvolution

The Advion deconvolution algorithm employs a combination of predictive charge envelope generation, overlap calculation with actual MS data acquired utilizing a maximum entropy goodness of fit approach followed by artifact removal through determination of peak significance. This novel approach allows for a rapid deconvolution over a wide mass range in seconds. It also allows a…

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Center for Free-Electron Laser Science (CFEL), Hamburg, Germany

"We are able to follow the process of most of our reactions which greatly facilitates our research."

Dr. Marta Sans, Research group of Prof. Dr. Arwen Pearson

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University of Ljubljana, Slovenia

"We recommend this to every medicinal chemistry department."

Dr. Janez Ilaš, Associate Professor, The Chair of Pharmaceutical Chemistry, Faculty of Pharmacy

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University of Hull, Chemistry Department

"A cost effective way to introduce practical LCMS studies to the undergraduate laboratory class."

Kevin Welham, Department of Chemistry

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Poster

Compact Mass Spectrometry (CMS) for Reaction Monitoring and Quality Control of Modern Solid Phase Peptide Synthesis (SPPS)

A recent development in mass spectrometry is the design of smaller sized MS systems with full analytical capability (compact mass spectrometry, CMS). CMS systems with fragmentation analysis are very cost effective analysis solutions and ideally suited for reaction and quality control in SPPS including detailed product characterization3. Here, we evaluate the utility of a system…

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University of Hull, Archibald Group

"The expression CMS has undoubtedly saved our group a great deal of time and has advanced our research."

Rhiannon Lee, Ph.D., Department of Chemistry and Positron Emission Tomography Research Centre

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Application Note

Recommendations for Transferring Peptide Mapping Methods to LC/MS Using Core-Shell Columns

With the emergence of new protein therapeutics, including biosimilars, biobetters and ADCs, peptide mapping by LC/MS is becoming more commonly used for the identification of post-translational modifications (PTMs), glycosylation, and conjugation sites, as well as primary sequence confirmation. The purpose of this study is to provide guidelines for developing optimal LC running conditions with Aeris™…

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Application Note

LC/MS Determination of Amino Acids Using Compact Mass Spectrometry

A combination of ion-ion interaction chromatography and a compact mass spectrometer presents a cost effective and powerful analysis system for the detection and quantification of amino acids in complex mixtures without the need for extra sample processing steps such as derivatizations.

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Application Note

Protein Analysis

Via Direct Injection using a Compact Mass Spectrometer with extended mass range (CMSL) The CMSL is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — ideal for large molecule applications such as the analysis of proteins. Its small footprint makes it the instrument…

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Application Note

LC/MS Analysis of Proteins

Using the expression CMSL compact mass spectrometer The CMSL is a high performance, easy to use, single quadrupole mass spectrometer with an extended mass range analysis capability to m/z 2000 — well-suited for large molecule applications such as the analysis of proteins. Its small footprint makes it the instrument of choice for space-restricted laboratories and…

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Montclair State University, Rotella Lab

"The expression CMS is easily serviceable by a non-expert."

David Rotella, PhD, Professor, Chemistry & Biochemistry

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Application Note

Peptide/Protein Analysis in Less than One Minute

The expression compact mass spectrometer (CMS) is a high performance, easy-to-use single quadrupole mass spectrometer with a small footprint to fit in space restricted labs. Priced substantially lower than other available systems, the CMS brings the analytical benefits of FIA/CMS and LC/CMS within the reach of more scientists than ever before.

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Virginia Tech, Matson Research Group

"There is no substitute for having a mass spectrometer a few steps away from your bench."

John Matson, PhD, Assistant Professor

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