expressionS CMS

for synthetic chemistry

The expression family of compact mass spectrometers provide essential information quickly and improves the chemist’s workflow. Designed with the synthetic organic chemist in mind, the expressionS is a flexible, transportable mass detector for small molecule analysis.

Unrivalled utility and flexibility

Reaction Monitoring

  • Compound identification for batch and flow chemistry
  • Confirm identity and purity quickly and accurately

Purification

  • Mass directed fraction collection for flash chromatography, Prep-LC and SFC

A versatile mass detector for:

  • Coupling to any (U)HPLC systems
  • Food safety
  • Water purity
  • Clinical diagnostics

VIDEO: How to Perform Easy & Rapid Compound ID

VIDEO: Mass Analysis from Liquids and Solids

VIDEO: Mass Analysis from TLC Plates

My recent initiative in providing and finding research funding has resulted in the purchase of the first Advion expression compact mass spectrometer to be installed in Australia in our research laboratory. This will improve the quality of the decision making process of my PG students in the research place leading to more efficient research outcomes and provide a mass spectral service to disciplines in our college at RMIT University.” Helmut Hugel – RMIT University, Australia

expression CMS Success Stories

See more success stories »

Purdue University

I was so impressed with the user-friendly interface and instrument setup that we installed a 4th expression CMS to be used in the undergraduate organic teaching lab.

Flaherty Lab

Read More »

Institute of Pharmaceutical Sciences, Eberhard Karls University, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

Read More »

Mass Spectrometry Facility, Department of Chemistry University of Birmingham

“The Chemists are spending significantly more time running reactions.”

Chi Tsang, Experimental Officer

Read More »

Technical University Munich, Garching, Germany

“The expression CMS is the perfect MS system for any research laboratory involved in synthetic organic chemistry and chemical analytics or small molecules to proteins.”

Dr. Tobias A.M. Gulder, Professor

Read More »

Recent expression CMS Publications

See more publications »

expression CMS Application Notes

See more application notes »

Simple LC/MS Analysis of Carbohydrates

Introduction There are many separation and detection methods are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, hydrophilicity…

Read More »

Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although…

Read More »

Toluene-Assisted APCI and Elemental Composition Prediction Using a Compact Mass Spectrometer

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective…

Read More »

Rapid Screening for Fentanyl in Urine using the Advion expressionL CMS with the Touch Express™ Open Port Sampling Interface (OPSI)

Quick and easy analysis methods for drugs of abuse are in high demand from health practitioners and law enforcement agencies on a global scale. In 2017, it was found that fentanyl, a fast-acting synthetic painkiller that is nearly 100 times stronger than morphine, has become the most widely abused synthetic opioid medicine – to the…

Read More »