Version 5.1 Release

Advion has just released a new version of Mass Express and Data Express – Version 5.1.

Advion has just released version 5.1 of its Mass Express software suite including updates to Mass Express, Data Express, Quant Express, and the much-anticipated Peak Express™ software for a robust package offering chemists the expertise of a dedicated mass spectroscopist, digging deep in to the data to find small, unknown peaks, as well as the ability to easily obtain quantitative LC/MS data.

The new Peak Express™ software featuring ΔS offers an ultra-sensitive technique that is able to detect even the smallest peaks amongst much larger signals from contaminants and chemical noise. It detects change, not absolute intensity, and zooms in on tiny rapid movements in a field of much larger static or slow-moving signals.

Quant Express, an addition to Advion’s user-friendly Mass Expres 4.0 software suite, is a full feature quantitation application for LC/MS data. The quantitation method can be configured in Mass Express before the analysis or in Quant Express post-analysis and it supports calibration curves, internal standards, QCs and unknowns using SIM or scan mode data. An enhanced peak detection algorithm ensures highest accuracy and ease of use.

Features implemented and improved in Mass Express:

  • Control of gradient/binary pump
  • Flow chemistry support
  • Support staggered heating: prevent source gas and transfer line heaters from turning on before capillary heater is equilibrated
  • Features implemented and improved in Data Express
  • Multiple charge deconvolution; automatic and manual
  • Improvements to CheMS

To see what version you are running, click on the ‘i’ button in the System page in Mass Express.

If you wish to upgrade to the new software please contact info@advion.com for upgrade instructions.

expression CMS Success Stories

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Purdue University

I was so impressed with the user-friendly interface and instrument setup that we installed a 4th expression CMS to be used in the undergraduate organic teaching lab.

Flaherty Lab

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Institute of Pharmaceutical Sciences, Eberhard Karls University, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

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Mass Spectrometry Facility, Department of Chemistry University of Birmingham

“The Chemists are spending significantly more time running reactions.”

Chi Tsang, Experimental Officer

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Technical University Munich, Garching, Germany

“The expression CMS is the perfect MS system for any research laboratory involved in synthetic organic chemistry and chemical analytics or small molecules to proteins.”

Dr. Tobias A.M. Gulder, Professor

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Recent expression CMS Publications

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expression CMS Application Notes

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Simple LC/MS Analysis of Carbohydrates

Introduction There are many separation and detection methods are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, hydrophilicity…

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Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although…

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Toluene-Assisted APCI and Elemental Composition Prediction Using a Compact Mass Spectrometer

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective…

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Rapid Screening for Fentanyl in Urine using the Advion expressionL CMS with the Touch Express™ Open Port Sampling Interface (OPSI)

Quick and easy analysis methods for drugs of abuse are in high demand from health practitioners and law enforcement agencies on a global scale. In 2017, it was found that fentanyl, a fast-acting synthetic painkiller that is nearly 100 times stronger than morphine, has become the most widely abused synthetic opioid medicine – to the…

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