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Mass Analysis of Air-Sensitive Samples Without Sample Prep

The Atmospheric Solids Analysis Probe (ASAP™) allows chemists to directly analyze liquid and solid samples by mass spectrometer without the need for sample preparation. The inert ASAP (iASAP) is a modification of this technique, allowing easy sampling of air-sensitive compounds, such as metal catalysts and organometallics, from reactions that are carried out in a glove box or Schlenk line to prevent oxidation. The iASAP probe is designed to provide:

Mass analysis without sample decomposition
Real-time reaction monitoring
No sample preparation
Atmospheric pressure chemical ionization (APCI)
Publication quality data in < 30 seconds

Watch the video: Advion’s Inert Atmospheric Solids Analysis Probe

expression CMS Success Stories

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University of Cambridge, Ley Group

“I would recommend the system to any group that works with continuous flow chemistry, especially those that need real time analysis of stream compositions.”

Daniel E. Fitzpatrick, Ph. D Candidate, Student Researcher & Founder, ChemInventory

Research Analyst – University of Leiden

“I incorporated the expression CMS as a TLC/MS system because of its simplicity, low cost and the brilliant combination with the Plate Express.”

Dr. Hans van den Elst, Research Analyst, University of Leiden

Department of Chemistry – Creighton University

“It’s easy, walk-up use with straightforward swapping of ESI and APCI sources make it a reliable, productive tool for determining synthetic success.”

Dr. Martin Hulce, Department of Chemistry, Creighton University

Cyclotron and Radiochemistry Research Program – UNC School of Medicine

“The convenience of having a mass spectrometer in our laboratory means that we can increase working efficiencies.”

Dr. Zibo Li, Department of Radiology UNC School of Medicine

Recent expression CMS Publications

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A metabolite profiling method for diagnosis of precancerous cervical lesions and HPV persistence

Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer

Synthesis and full characterization of an iridium B–H activation intermediate of the monocarba-closo-dodecaborate anion

A diagnostic test for controlled substances in urine and oral fluid using portable mass spectrometry

expression CMS Application Notes

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iASAP Analysis of Air-Sensitive Compounds via Inert Sampling Techniques

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®)…

Identification of a Pesticide Used in Lawn Care by vAPCI Compact Mass Spectrometry

At regular intervals throughout the year a local lawn service applies pesticides to the lawn surrounding the Advion headquarters in Ithaca, NY. The grass is very uniform and not a single dandelion or crabgrass plant is visible – so we wondered, what chemical do they use? After an application in the early spring, we sampled…

Analyses of Different Grades of Olive Oil by Volatile Mass Spectrometry

In this application note, we demonstrate the use of the Advion expression CMS with a volatile APCI (vAPCI) ion source to analyze extra-virgin, virgin, and lampante olive oil samples. We show statistical analysis allowing us to categorize and identify olive oil samples by their grade. This technique allows us to test individual olive oil samples and…

Classifying Cheeses by vAPCI Compact Mass Spectrometry

Cheese is one of the world’s most popular food types, with a wide variety available for consumers. The scents and flavors of cheeses, so characteristic to each type of cheese, stem from a complex mixture of chemicals, including free fatty acids. While this mixture is affected by a wide variety of factors we can use…