Direct mass analysis from solid and liquid samples

The expression CMS provides essential information quickly and improves the chemist’s workflow. Modern organic labs have become automated, yet real-time mass assays remain out of reach using conventional LC/MS systems. The direct analysis probe, otherwise known as ASAP® (Atmospheric Solids Analysis Probe) permits chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.

  • No sample preparation
  • No chromatography
  • Publication quality data in < 1 minute
  • Affordable sample analysis

photo_product_expression-chem-diagramChemists dip the closed end of the capillary into the sample of interest (even complex mixtures) or scrape the surface of a solid, and then place the capillary into the CMS for analysis. Clean-up and analysis is a single step. Involatile buffers and salts remain on the capillary ensuring they do not suppress ionization or interfere with the measurement, while the compounds of interest are identified by the CMS.

Ideal for:

  • Reaction monitoring
  • Compound ID
  • Food safety
  • Natural products

Watch the video: Advion’s Atmospheric Solids Analysis Probe

expression CMS Success Stories

See more success stories »

Mass Spectrometry Facility, Department of Chemistry University of Birmingham

“The Chemists are spending significantly more time running reactions.”

Chi Tsang, Experimental Officer

Read More »

Technical University Munich, Garching, Germany

“The expression CMS is the perfect MS system for any research laboratory involved in synthetic organic chemistry and chemical analytics or small molecules to proteins.”

Dr. Tobias A.M. Gulder, Professor

Read More »

New Path Molecular Ltd, United Kingdom

“expression CMS meets our requirements for an instrument that is intuitive to use, robust and capable of being maintained, expanded and serviced without manufacturer call outs.”

Dr. Gary Tarver, Lead Chemist

Read More »

Corden Pharma Switzerland LLC, Liestal, Switzerland

"We use the Advion expression CMS as a robust and versatile detector in our chromatographic processes, both MPLC and HPLC."

Dr. Markus Juza, Purification Expert

Read More »

Recent expression CMS Publications

See more publications »

expression CMS Application Notes

See more application notes »

Fast Identification of Artificial Vanilla Flavor in Vanilla Extract by ASAP® Compact Mass Spectrometry

The expression CMS coupled with the Atmospheric Solids Analysis Probe (ASAP®) is used to quickly identify the presence of artificial vanilla, as well as confirm the purity of products marketed as such. This technique provides a fast and easy method for purity analysis.

Read More »

Fast Screening for Purity and Adulterants in Coconut Oil by ASAP® Compact Mass Spectrometry

The expression CMS coupled with the Atmospheric Solids Analysis Probe (ASAP®) is used to determine purity and detect adulterants in coconut oil. In this application note, pure coconut oil is tested against a sample of coconut oil adulterated with canola oil for comparative data analysis and a fast and easy method for purity analysis.

Read More »

iASAP Analysis of Air-Sensitive Compounds via Inert Sampling Techniques

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®)…

Read More »

Identification of a Pesticide Used in Lawn Care by vAPCI Compact Mass Spectrometry

At regular intervals throughout the year a local lawn service applies pesticides to the lawn surrounding the Advion headquarters in Ithaca, NY. The grass is very uniform and not a single dandelion or crabgrass plant is visible – so we wondered, what chemical do they use? After an application in the early spring, we sampled…

Read More »