CheMS

Software for simplified mass spectrometer operation and compound identification

The CheMS user interface simplifies the mass spectrometry experience and makes it more  accessible in chemistry and biochemistry laboratories. The user interface allows users to quickly select the workflow and type of compound they wish to analyze in just a few clicks  of the mouse and the software automatically optimizes the ion source and data acquisition parameters to ensure they get the data they need for decision-making. This allows the chemist to obtain optimal data without needing to be an expert in mass spectrometry.

  • Effortless method and instrument set-up for a range of sample
    introduction techniques, optimized for your sample type.
  • Simplified mass spectral interpretation with automatic identification
    of peaks related to your compounds of interest.
  • Flexibility to scan across the full mass range to search for unkowns, or
    to focus on a specific area for a compound of interest.
  • Integrated with Advion sampling techniques; direct syringe injection,
    Plate Express (TLC/CMS) and ASAP direct probe analysis.
  • Works in conjunction with Mass Express for fully versatile software.

Download CheMS Product Note

expression CMS Success Stories

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University of Minnesota, Therapeutics Discovery Development

We have been extremely happy with our Advion system and predict that it will quickly become a workhorse in any synthetic organic or medicinal chemistry laboratory.

Rebecca Cuellar, PhD

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Purdue University

I was so impressed with the user-friendly interface and instrument setup that we installed a 4th expression CMS to be used in the undergraduate organic teaching lab.

Flaherty Lab

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ETH, Laboratory of Organic Chemistry, Zurich, Switzerland

“The expression CMS allows us to efficiently analyze the mass of newly formed compounds in (almost) real time.”

Wennemers Research Group

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Eberhard Karls University, Institute of Pharmaceutical Sciences, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

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Recent expression CMS Publications

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expression CMS Application Notes

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UHPLC/CMS Analysis of Casein Proteins in Milk

In this application note, the Advion UHPLC/CMS system is used to analyze casein proteins in whole milk extract to separate and detect β-casein-B, -A1, and -A2, as well as K-casein and αs1-casein variants. This method is also suitable for a quick, relative quantitation of the β-casein-B, -A1, and -A2 variants in standards of β-casein. 

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LC/MS Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum

In this application note, a simple and cost-effective SIM LC/MS analytical approach employing the Advion expression Compact Mass Spectrometer (CMS) is described for the quantitation of 25-hydroxyvitamin D2 and D3 in human serum.

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Simple LC/MS Analysis of Carbohydrates

Introduction There are many separation and detection methods are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, hydrophilicity…

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Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although…

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