Specifications

  • Ion Source: ESI, APCI, or APCI/ASAP
  • Polarity: Positive & negative ion switching in a single analysis
  • Flow Rate Range: ESI: 10 µL/min to 1 mL/min
    APCI: 10 µL/min to 2 mL/min
  • m/z Range: expressionS m/z 10 to 1,200
    expressionL m/z 10 to 2,000
  • Acquisition Speed: 10,000 m/z units/sec
  • Sensitivity (ESI): 10 pg reserpine (FIA – 5 µL injection at 100 µL/min) 100:1 S/N (RMS) with SIM of m/z 609.3
  • Accuracy: ±0.1 m/z units of the entire acquisition range
  • Stability0.1 m/z units at m/z 1,200 over 12 hour period operating temperature of 20ºC ±1ºC
  • Polarity Switching Speed: 50 ms
  • Dynamic Range: 4.5 orders of magnitude

expression CMS Success Stories

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University of Minnesota, Therapeutics Discovery Development

We have been extremely happy with our Advion system and predict that it will quickly become a workhorse in any synthetic organic or medicinal chemistry laboratory.

Rebecca Cuellar, PhD

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Purdue University

I was so impressed with the user-friendly interface and instrument setup that we installed a 4th expression CMS to be used in the undergraduate organic teaching lab.

Flaherty Lab

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ETH, Laboratory of Organic Chemistry, Zurich, Switzerland

“The expression CMS allows us to efficiently analyze the mass of newly formed compounds in (almost) real time.”

Wennemers Research Group

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Eberhard Karls University, Institute of Pharmaceutical Sciences, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

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Recent expression CMS Publications

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expression CMS Application Notes

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Simple LC/MS Analysis of Carbohydrates

Introduction There are many separation and detection methods are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, hydrophilicity…

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Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although…

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Toluene-Assisted APCI and Elemental Composition Prediction Using a Compact Mass Spectrometer

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective…

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Rapid Screening for Fentanyl in Urine using the Advion expressionL CMS with the Touch Express™ Open Port Sampling Interface (OPSI)

Quick and easy analysis methods for drugs of abuse are in high demand from health practitioners and law enforcement agencies on a global scale. In 2017, it was found that fentanyl, a fast-acting synthetic painkiller that is nearly 100 times stronger than morphine, has become the most widely abused synthetic opioid medicine – to the…

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