Direct mass analysis from solid and liquid samples

For full product details and specs, please download our product note featuring the ASAP sample technology:

The expression CMS provides essential information quickly and improves the chemist’s workflow. Modern organic labs have become automated, yet real-time mass assays remain out of reach using conventional LC/MS systems. The direct analysis probe, otherwise known as ASAP® (Atmospheric Solids Analysis Probe) permits chemists affordable and reliable sample analysis of solid and liquid samples such as reaction mixtures, food samples, natural products and tablets.

  • No sample preparation
  • No chromatography
  • Publication quality data in < 1 minute
  • Affordable sample analysis

photo_product_expression-chem-diagramChemists dip the closed end of the capillary into the sample of interest (even complex mixtures) or scrape the surface of a solid, and then place the capillary into the CMS for analysis. Clean-up and analysis is a single step. Involatile buffers and salts remain on the capillary ensuring they do not suppress ionization or interfere with the measurement, while the compounds of interest are identified by the CMS.

Ideal for:

  • Reaction monitoring
  • Compound ID
  • Food safety
  • Natural products

Watch the video: Advion’s Atmospheric Solids Analysis Probe

expression CMS Success Stories

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University of Minnesota, Therapeutics Discovery Development

We have been extremely happy with our Advion system and predict that it will quickly become a workhorse in any synthetic organic or medicinal chemistry laboratory.

Rebecca Cuellar, PhD

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Purdue University

I was so impressed with the user-friendly interface and instrument setup that we installed a 4th expression CMS to be used in the undergraduate organic teaching lab.

Flaherty Lab

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ETH, Laboratory of Organic Chemistry, Zurich, Switzerland

“The expression CMS allows us to efficiently analyze the mass of newly formed compounds in (almost) real time.”

Wennemers Research Group

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Eberhard Karls University, Institute of Pharmaceutical Sciences, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

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Recent expression CMS Publications

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expression CMS Application Notes

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UHPLC/CMS Analysis of Casein Proteins in Milk

In this application note, the Advion UHPLC/CMS system is used to analyze casein proteins in whole milk extract to separate and detect β-casein-B, -A1, and -A2, as well as K-casein and αs1-casein variants. This method is also suitable for a quick, relative quantitation of the β-casein-B, -A1, and -A2 variants in standards of β-casein. 

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LC/MS Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum

In this application note, a simple and cost-effective SIM LC/MS analytical approach employing the Advion expression Compact Mass Spectrometer (CMS) is described for the quantitation of 25-hydroxyvitamin D2 and D3 in human serum.

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Simple LC/MS Analysis of Carbohydrates

Introduction There are many separation and detection methods are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, hydrophilicity…

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Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although…

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