expression CMS

High performance compact mass spectrometer

The expression CMS provides essential information quickly and improves the chemist’s workflow. Modern organic labs have become automated; faster and more critical reactions require co-located versatile analytics — the expression CMS solves this at an affordable price.

"Our laboratory has recently purchased an Advion expression Compact Mass Spectrometer. Our choice was not only related to the small footprint but also to the versatility of the system. The Advion expression CMS provides the quality of results necessary to improve research outcomes in our hit and lead discovery efforts."

Tiago Rodrigues – ETH Zürich, Switzerland

Versatility

Few laboratories analyze one type of sample or one technique all day, every day. Most require the ability to analyze a range of samples using more than one technique. This allows for a more complete identification and characterization of samples. The expression CMS integrates with nearly every chemistry technique.

  • Thin-layer Chromatography (TLC by Plate Express)
  • Atmospheric Solids Analysis Probe (ASAP)
  • Inert Atmospheric Solids Analysis Probe (iASAP)
  • Touch Express Open Port Sampling Interface (OPSI)
  • Volatile APCI (vAPCI)
  • AVANT Customizable (U)HPLC Systems
  • Flow Injection
  • Flow Chemistry
  • Flash Chromatography
  • Preparative Liquid Chromatography (Prep-LC)
  • Supercritical Fluids Chromatography (SFC)

VIDEO: How to Perform Easy & Rapid Compound ID

"My recent initiative in providing and finding research funding has resulted in the purchase of the first Advion expression compact mass spectrometer to be installed in Australia in our research laboratory. This will improve the quality of the decision making process of my PG students in the research place leading to more efficient research outcomes and provide a mass spectral service to disciplines in our college at RMIT University." Helmut Hugel - RMIT University, Australia

expression CMS Success Stories

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University of Minnesota, Therapeutics Discovery Development

We have been extremely happy with our Advion system and predict that it will quickly become a workhorse in any synthetic organic or medicinal chemistry laboratory.

Rebecca Cuellar, PhD

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Purdue University

I was so impressed with the user-friendly interface and instrument setup that we installed a 4th expression CMS to be used in the undergraduate organic teaching lab.

Flaherty Lab

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ETH, Laboratory of Organic Chemistry, Zurich, Switzerland

“The expression CMS allows us to efficiently analyze the mass of newly formed compounds in (almost) real time.”

Wennemers Research Group

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Eberhard Karls University, Institute of Pharmaceutical Sciences, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

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Recent expression CMS Publications

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expression CMS Application Notes

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UHPLC/CMS Analysis of Casein Proteins in Milk

In this application note, the Advion UHPLC/CMS system is used to analyze casein proteins in whole milk extract to separate and detect β-casein-B, -A1, and -A2, as well as K-casein and αs1-casein variants. This method is also suitable for a quick, relative quantitation of the β-casein-B, -A1, and -A2 variants in standards of β-casein. 

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LC/MS Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum

In this application note, a simple and cost-effective SIM LC/MS analytical approach employing the Advion expression Compact Mass Spectrometer (CMS) is described for the quantitation of 25-hydroxyvitamin D2 and D3 in human serum.

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Simple LC/MS Analysis of Carbohydrates

Introduction There are many separation and detection methods are available for the determination of saccharides. These include GC-MS with derivatization, HPLC-UV with derivatization, HPAEC-PAD (High-performance anion-exchange chromatography coupled with pulsed amperometric detection), and LC-MS. The availability of a sensitive and accurate method is still a challenge. For an LC-MS method, given the high polarity, hydrophilicity…

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Urinary Cortisol Quantitation Using Ultra High Pressure Liquid Chromatography/Compact Mass Spectrometry

Introduction Cortisol is an important steroid hormone produced from cholesterol in the adrenal cortex. Its secretion is closely regulated by the Adrenocorticotropic hormone (ACTH). Most cortisol is protein-bound, and only unbound cortisol is excreted in urine. Measurement of cortisol in urine is typically used in the diagnosis of Cushing’s syndrome, a disorder of hypercortisolism. Although…

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