Join us for a webinar with Chris Horbaczewskyj from the University of Leeds and Jack Henion, Advion’s Chief Scientific Founder on Thursday, April 26, 2018. Chris is working on the self-optimisation of continuous flow reactions using online mass spectrometry. Continuous flow and process optimisation are relatively new methods involved in chemical synthesis. This webinar outlines the workflow of the Bourne group at the University of Leeds for process development applications.
Register for this webinar to learn more!
Join us for a Webinar with Chris Horbaczewskyj of the University of Leeds and Jack Henion, Advion’s Chief Scientific Founder, on Thursday, April 26, 2018 at 10am EST / 3PM GMT.
This presentation outlines the work carried out within the Bourne group at the University of Leeds for process development applications:
- Use of flow chemistry with online HPLC in the self-optimisation of reactions
- Use of online mass spectrometry for the optimisation of continuous flow reactions using an experimental design approach
- The development of new algorithms for multiple variable optimisation in chemical systems
Join us on the expo floor September 27-28 in Las Vegas, NV! If you’re attending the expo, analytical testing for ingredients is essential for every supplier and buyer. Stop by to learn how Advion’s instruments can streamline your internal labs and help you ensure you have pure, quality, pesticide-free product.
Please stop by booth #XX117 to learn more about Advion’s full array of mass spec testing tools, featuring easy-to-use, novel sample techniques for maximum efficiency in the lab.Find out more »
Join us on the expo floor August 20-22 in Washington, DC for the annual Fall American Chemical Society conference. Here you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques. Please stop by booth #1401 to learn more about Advion’s full array of MS tools for chemists.
This year, we are hosting a workshop titled, “Mass Spectrometry for Chemists – Direct Analysis of TLC Plates, Solids, Liquids and Gases.”
Date/Time/Location: Tuesday, August 22, 9:30a-12p — Room 4 on the Conference Floor, complimentary breakfast will be servedFind out more & register for the workshop now »
ASMS 2017 brought nearly 7,000 attendees under one roof, ready to learn the newest products and latest applications in the world of mass spec. The Advion CMS and TriVersa NanoMate were both a topic for discussion, featured during Advion poster sessions, and also included in posters from customers who have found the instruments an essential part of their mass spec workflow.See the Highlights »
Join us in Indy for the annual ASMS Conference on Mass Spectrometry (MS) and Allied Topics. From posters to short courses, you will have many opportunities to learn about Advion’s suite of mass spec products and novel sample techniques. Please stop by booth #506 during the show to learn more about Advion’s full array of MS tools for chemists.Read More »
The 100th Annual Canadian Chemistry Conference – A Celebration of Chemistry, May 28 – June 1, Toronto
Join us at the Canadian Chemistry Conference for several days’ worth of education, instrumentation news and networking. Our team will be both exhibiting and giving an oral presentation during the event. Visit booth #603 to view the latest advancements in single-quadrupole mass spectrometry.Read More »
“We have the expression linked to an HPLC instrument and it is used as an open access system. The combination of UV purity data along with MS confirmation is incredibly powerful for our chemists. The instrument is networked so our chemists can then process and review data from their desks.”Download the customer profile »
DYESTUFF ANALYSIS OF CULTURAL HERITAGE OBJECTS by Direct Analysis Probe on a Compact Mass Spectrometer
The scientific investigation of cultural heritage objects is the only access to knowledge about long-gone, ancient societies and their cultural, technological as well as their social stage of development. In addition, the materials used by our ancestors, e.g. their textiles and the organic dyestuff to colorize these materials, allow researchers to draw some conclusions about cultural exchanges and trading routes. But in-depth knowledge about materials and dyestuff is also of highest importance for proper conservation and restauration of these materials. Specimens, however, are rare and available only in minute amounts. For their investigation preferentially non-destructive or at least minimal invasive methods have to be used.Download the application note »
Compact Mass Spectrometry (CMS) for the Detection and Quantification of Chemical Compounds Related to Cannabis
The cannabinoid makeup of cannabis has significantly changed over the past few decades. Efforts to increase the psychotropic effects of cannabis have resulted in a THC content for current strains of the crop of 30 to 40 percent compared with only 5 percent 30 years ago. Up-regulating the THC content of the plant causes a loss of other cannabinoids the plant is producing. Some of these other cannabinoids, such as CBD, are believed to be responsible for its medical benefits.Watch the video »
Plate ExpressTM is a device that provides a simple, automated means of obtaining mass spectra directly from TLC plates, creating a technique known as TLC/MS. Combined with Advion’s expression® compact mass spectrometer (CMS) this becomes TLC/CMS. Using this technique chemists can quickly and confidently identify products even in complex mixtures without additional sample preparation.Download the product note »
Natural products, the underlying active components and their use in traditional medicine are of increased interest in the field of pharmaceutical research. The naturally occurring active ingredients are ideal chemical starting structures to improve upon in the pharmaceutical drug development process and consequently half of all currently approved drugs in the US are based on natural products. It is therefore not surprising that natural product analysis is a field of major interest world wide. Here, we present a simple example of the added benefits of mass spectrometry in typical natural product analysis workflows based on an alcoholic extract of nutmeg.Download the application note »
This application note presents an online thin-layer chromatography (TLC)/CMS technique using the Advion expression compact mass spectrometer (CMS) and Plate ExpressTM interface to provide compound structural information without sample preparation after TLC separation. A Suzuki reaction for the synthesis of 4-aminobiphenyl will be demonstrated. The online TLC/CMS technique provides rapid and accurate determination of reaction mixture components without the need for off-line TLC sample preparation procedures.Download the application note »
THC PLANT MATERIAL ANALYSIS Using Compact Mass Spectrometry for Product Control and Law Enforcement of cannabis-related Plant Products
Analysis of the active components of the cannabis sativa plant is required both for law enforcement where these compounds are illegal and also as a tool for product control and optimization in the increasing number of legal markets for cannabis plant products. Whenever simple, unequivocal and legally defensible analysis methods for the detection and quantification of plant metabolites are required, mass spectrometry is the detector of choice.Download the application note »
Sudan Dyes are synthesized azo-dyes which are widely used to generate color in plastics, leather, fabrics, oil, waxes, etc. They are classified as Group 3 carcinogens by the International Agency for Research on Cancer (IARC) and are banned as food additives worldwide. However, in some countries these dyes are still occasionally used in order to intensify the color in products. In this note, a TLC/CMS method using expression compact mass spectrometer (CMS) coupled with the Plate ExpressTM Interface (Advion, Ithaca, NY) is introduced for the detection of 7 Sudan dyes in a chili matrix. The primary advantage of TLC/CMS analysis is the ability to sample directly from the TLC plate without further sample preparation after the TLC separation is done. Molecular weight information of sample components can be determined by the mass spectra from the eluted TLC spots.Download the application note »
With over 20 years of mass spectrometry and chemistry expertise, Advion has produced a family of compact mass spectrometers designed for the chemist. The affordability, small size and ease of use make them ideal for use directly at the chemist’s bench, giving immediate answers and informed decisions instead of waiting.Download the brochure »
Expanded application note. DIRECT SAMPLE ANALYSIS: Detecting THC/Cannabinoids in Contraband by Compact Mass Spectrometry
This is an expanded application note with more data regarding direct sample analysis of THC in suspected contraband and on skin. Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.Download the application note »
Screening of explosives residues without sample preparation using a direct sample analysis probe on the expression CMS
The ability to effectively screen passengers with minimal personal contact is critical. Ion mobility detectors used at many airports can be inaccurate and provide many false-positives and false-negatives. Advanced Imaging Technology (AIT) screening techniques are very useful for detecting concealed weapons and explosive devices located on passengers and/or in their belongings, however are unable to detect trace amounts of explosive residues.Download the application note »
Direct sample analysis is possible via an Atmospheric Solids Analysis Probe (ASAP®) combined with atmospheric pressure chemical ionization (APCI) on a compact mass spectrometer (CMS). This technique allows for the rapid investigation (<30 sec) of material suspected of containing THC/cannabinoids.Download the application note »
Quantitative spatial analysis of the mouse brain lipidome by pressurized liquid extraction surface analysis (PLESA)
Here we describe a novel surface sampling technique termed pressurized liquid extraction surface analysis (PLESA), which in combination with a dedicated high resolution shotgun lipidomics routine enables both quantification and in-depth structural characterization of molecular lipid species extracted directly from tissue sections.Read the abstract »