Reaction monitoring

Real-time reaction monitoring answers

The expression CMS addresses the need of organic and synthetic chemists to understand the optimal time to quench a reaction mixture. They can obtain answers within minutes rather than hours or days. Additionally, the multiple inlet techniques of the atmospheric samples analysis probe (ASAP), Plate Express – TLC Plate Reader, or direct injection provides the ultimate in flexibility for sample analysis without the need for complex sample preparation.

expression CMS Success Stories

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Therapeutics Discovery & Development, University of Minnesota

We have been extremely happy with our Advion system and predict that it will quickly become a workhorse in any synthetic organic or medicinal chemistry laboratory.

Rebecca Cuellar, PhD

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Institute of Pharmaceutical Sciences, Eberhard Karls University, Tübingen, Germany

"The expression CMS/Plate Express™ couple can be recommended to organic or medicinal chemistry groups in general since it seamlessly integrates into organic synthesis workflows."

Dr. Stefan Laufer, Professor of Pharmaceutical Sciences

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Department for Homogeneous Catalysis, Max-Planck-Institut für Kohlenforschung

“Rapid characterization of reaction products combined with the lowest effort of sample preparation”

List Research Group, Max-Planck-Institut für Kohlenforschung

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Center for Free-Electron Laser Science (CFEL), Hamburg, Germany

"We are able to follow the process of most of our reactions which greatly facilitates our research."

Dr. Marta Sans, Research group of Prof. Dr. Arwen Pearson

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Recent expression CMS Publications

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expression CMS Application Notes

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Toluene-Assisted APCI and Elemental Composition Prediction Using a Compact Mass Spectrometer

OVERVIEW Toluene-assisted APCI (TAPCI) can generate (M)+· and (M+H)+ ions from analytes that cannot be ionized by ESI or APCI. Elemental formula prediction at 250 ppm accuracy and isotope distribution matching by TAMI (Tal Aviv Molecule Identifier) supports analyte identification. Combining both TAPCI and TAMI on the expression compact mass spectrometer (CMS) provides a cost-effective…

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iASAP Analysis of Air-Sensitive Compounds via Inert Sampling Techniques

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®)…

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Flow Chemistry Monitoring & Optimization Using Compact Mass Spectrometry

This note covers work carried out at Leeds University with co-workers from Durham University in the area of flow chemical synthesis using the expression CMS (Advion, Ithaca, NY). Two different reactions are described.

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Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS

Co-authored with Merck Millipore in Darmstadt, Germany, this application note provides an example of TLC/CMS (thin-layer chromatography-compact mass spectrometry) for the determination of 4-aminobiphenyl in its reaction mixture.

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