Reaction monitoring

Real-time reaction monitoring answers

The expression CMS addresses the need of organic and synthetic chemists to understand the optimal time to quench a reaction mixture. They can obtain answers within minutes rather than hours or days. Additionally, the multiple inlet techniques of the atmospheric samples analysis probe (ASAP), Plate Express – TLC Plate Reader, or direct injection provides the ultimate in flexibility for sample analysis without the need for complex sample preparation.

expression CMS Success Stories

See more success stories »

Department for Homogeneous Catalysis, Max-Planck-Institut für Kohlenforschung

“Rapid characterization of reaction products combined with the lowest effort of sample preparation”

List Research Group, Max-Planck-Institut für Kohlenforschung

Read More »

Center for Free-Electron Laser Science (CFEL), Hamburg, Germany

"We are able to follow the process of most of our reactions which greatly facilitates our research."

Dr. Marta Sans, Research group of Prof. Dr. Arwen Pearson

Read More »

Albert-Ludwigs-University, Freiburg, Germany

"We can now analyse highly air sensitive compounds without difficulty and outside a glove box."

Prof. Dr. Ingo Krossing, Institute for Inorganic and Analytical Chemistry

Read More »

Polish Academy of Sciences

"Instant feedback about the reaction progress and aid in isolation of the product saves a lot of time."

Prof. Dr. Janusz Jurczak, Stereo-controlled Organic Synthesis and Supramolecular Chemistry, Institute of Organic Chemistry

Read More »

Recent expression CMS Publications

See more publications »

expression CMS Application Notes

See more application notes »

iASAP Analysis of Air-Sensitive Compounds via Inert Sampling Techniques

Many chemical reactions carried out by synthetic chemists involve air-sensitive compounds such as metal catalysts and organometallics and must therefore be carried out in a glove box or using a Schlenk line to prevent oxidation and hydrolysis. Sampling and transportation of these samples to a mass spectrometer by an Atmospheric Solids Analysis Probe (ASAP ®)…

Read More »

Complete Reaction-Monitoring Solution

Reaction monitoring is a key aspect in a range of chemistry environments from chemical synthesis to drug discovery to understanding natural products and protein synthesis. To understand the optimal time to quench a reaction for maximum yield as well as to monitor a reaction real-time is vital to many medicinal and synthetic organic chemists. The…

Read More »

Flow Chemistry Monitoring & Optimization Using Compact Mass Spectrometry

This note covers work carried out at Leeds University with co-workers from Durham University in the area of flow chemical synthesis using the expression CMS (Advion, Ithaca, NY). Two different reactions are described.

Read More »

Analysis of 4-Aminobiphenyl and 4-Bromoanilin on normal phase TLC using TLC/MS

Co-authored with Merck Millipore in Darmstadt, Germany, this application note provides an example of TLC/CMS (thin-layer chromatography-compact mass spectrometry) for the determination of 4-aminobiphenyl in its reaction mixture.

Read More »