Conduct fast and complete protein identification and PTM characterization, including glycan analysis

Using the TriVersa NanoMate® as a versatile ion-source to support both top-down as well as bottom-up proteomics, utilize the benefit of nano-electrospray to fully characterize a protein of interest including its PTMs and glycan structure.

  • Combined top-down and bottom up workflow support
  • Simultaneous fraction collection and on-line LC/MS for further infusion re-analysis of fractions
  • Long infusion spray times allow for multiple MS modes such as fragmentation (ECD, ETD, CID, IRMPD), precursor or neutral loss analysis or MSn tree experiments
  • Improved signal-to-noise due to the power of signal averaging
  • Automated protein analysis in 96 or 384 well plate format

Please also visit our technical resource page for details and examples.

TriVersa NanoMate Success Stories

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University of Birmingham, Cooper Mass Spectrometry Group

"The TriVersa NanoMate revolutionized nanospray."

Dr. Helen Cooper, Senior Lecturer, School of BioSciences

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Max Planck Institute of Molecular Plant Physiology Golm, Germany

"I can’t imagine running these analyses without the TriVersa NanoMate"

Dr. Patrick Giavalisco, Research Group Leader

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University of Bristol, School of Chemistry

"Advion’s technology gives you what you want very quickly."

John Crosby, Senior Lecturer, Organic & Biological Chemistry

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Institute for Research in Biomedicine (IRB Barcelona), Spain

"If I could, I would have a TriVersa NanoMate on all of our mass spectrometers."

Marta Vilaseca, PhD, Mass Spectrometry Core Facility Manager

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Recent TriVersa NanoMate Publications

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TriVersa NanoMate Application Notes

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Using the TriVersa NanoMate® for Rapid Analyte Identification Based on Static nESI-MS/MS (Infusion MS/MS) Employing Polarity Switching Experiments

Automated static nano-ESI/MS/MS (Infusion MS/MS) is an easy-to-use and high-throughput approach to analyte identification. It is particularly useful in the field of shotgun lipidomics, which itself has great potential for biomarker discovery and gained some significant attention in the last couple of years (Schuhmann et al. 2012; Jung et al. 2011; Han et al. 2011).…

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Using the TriVersa NanoMate® for Rapid Analyte Identification Based on Static nESI-MS/MS (Infusion MS/MS)

In many cases of routine protein identification, processing times become the major bottleneck at the core facility. Although a nano-LC/MS/MS approach is recognized as a general strategy for protein identification, the typical 30-120 min run-time prohibits fast turnaround times. The TriVersa NanoMate offers a more rapid approach for the infusion of the protein digest, with…

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