The ESI Chip
The ESI Chip unleashes the power of mass spectrometry through miniaturization. This microfluidics chip contains an array of nanoelectrospray nozzles, each one-fifth the diameter of a human hair, etched in a silicon wafer. The fabrication method is highly reproducible to ensure the integrity of each nozzle. The unique field strength created by the nanoelectrospray nozzles allows for a more efficient ionization and stable electro-spray.
The TriVersa NanoMate is controlled with a dedicated software program. ChipSoft 10 allows users to control all aspects of the system including spray volumes, spray pressure, sample temperatures, and sequence of sample analysis. The software also integrates with a spray sensor to automatically change nozzles if no spray is detected.
Developer’s kit – this option for ChipSoft 10 allows users to mix protein and ligand quantitatively prior to infusion for fully automated Kd determinations. It also allows control of reaction conditions such as incubation time and temperature, surface modifications or digestions.
Developer’s kit also uses the novel LESA PLUS workflow a surface analysis with nano LC separations from – 600µ locations.