photo_triversa-nanomate

TriVersa NanoMate®

The TriVersa NanoMate is the latest in chip-based electrospray ionization technology from Advion. It combines the strengths of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated system. It allows analysts to obtain more information from complex samples than with LC/MS alone.

The ESI Chip

The ESI Chip unleashes the power of mass spectrometry through miniaturization. This microfluidics chip contains an array of nanoelectrospray nozzles, each one-fifth the diameter of a human hair, etched in a silicon wafer. The fabrication method is highly reproducible to ensure the integrity of each nozzle. The unique field strength created by the nanoelectrospray nozzles allows for a more efficient ionization and stable electro-spray.

Software

The TriVersa NanoMate is controlled with a dedicated software program. ChipSoft 10 allows users to control all aspects of the system including spray volumes, spray pressure, sample temperatures, and sequence of sample analysis. The software also integrates with a spray sensor to automatically change nozzles if no spray is detected.

Software Options:

Developer’s kit – this option for ChipSoft 10 allows users to mix protein and ligand quantitatively prior to infusion for fully automated Kd determinations. It also allows control of reaction conditions such as incubation time and temperature, surface modifications or digestions.

Developer’s kit also uses the novel LESA PLUS workflow a surface analysis with nano LC separations from – 600µ locations.

TriVersa NanoMate Success Stories

See more success stories »
photo_profile_ejsing

University of Southern Denmark

"Essential for any Lipidomics Laboratory."

Christer S. Ejsing, PhD, Associate Professor

Read More »
photo_profile_cooper

University of Birmingham

"The TriVersa NanoMate revolutionized nanospray."

Dr. Helen Cooper, Senior Lecturer, School of BioSciences

Read More »
photo_profile_giavalisco

Max Planck Institute of Molecular Plant Physiology Golm, Germany

"I can’t imagine running these analyses without the TriVersa NanoMate"

Dr. Patrick Giavalisco, Research Group Leader

Read More »
photo_profile_crosby

School of Chemistry, University of Bristol – Bristol, UK

"Advion’s technology gives you what you want very quickly."

John Crosby, Senior Lecturer, Organic & Biological Chemistry

Read More »

Recent TriVersa NanoMate Publications

See more publications »

TriVersa NanoMate Application Notes

See more application notes »

Microorganism Surface Analysis Using the TriVersa NanoMate for Liquid Extraction Surface Analysis of Bacteria and Fungi

Liquid Extraction Surface Analysis Mass Spectrometry (LESA-MS) has been utilized for determination of small molecules, lipids and proteins from a variety of surfaces such as tissue sections, plant material, medical devices, TLC plates or DBS cards. It allows direct surface analysis without sample preparation from spot sizes of 1 mm diameter by aspiration of extraction…

Read More »

Pesticides from Food Surfaces Using LESA PLUS Liquid Extraction Surface Analysis PLUS LC Separation

Residues and contaminants in the food chain are an increasing problem due to high production volumes, large area distribution and import/export of food items across the world. The novel LESAPLUS surface analysis approach combines the standard liquid extraction surface analysis with an additional step of a nano liquid chromatography separation. This combination is ideally suited…

Read More »

Using the TriVersa NanoMate with LESA for Analyte Profiling in Material Science

Surface analysis techniques have gained significant attention over the last couple of years with LESA being an interesting alternative to techniques such as SIMS or MALDI imaging. This note demonstrates practical applications for LESA in the material sciences.

Read More »