A Microfluidic Flow-Chemistry System

The NanoTek is a modular, microfluidic synthesis system with the ability to  undertake both microscale and macroscale synthesis of both PET and SPECT imaging probes using a variety of isotopes. Modular components give the user maximum flexibility producing  tracers for both research and clinical applications. The NanoTek produces higher-yielding, higher-purity   compounds using substantially less starting materials than possible with conventional vial based reactors.  Initial optimization of synthesis conditions is typically completed in 1 – 2 minutes and the unique configuration of the system allows the user to undertake multiple syntheses in one day with one delivery of activity and using ugm quantities of reagent.

[ Animation: Automated Fluoride Drying and Resolubilization ]

Microfluidic Flow-Chemistry offers:

  • Speed –  Novel tracer optimization experiments are typically completed in one to two days.  Depending on the isotope as many as 30 to 50 reactions can be completed within one day.
  • Flexible – Research, Pre-Clinical and Clinical production (including dose-on-demand) processes can all be undertaken using the one platform.
  • Efficient – Final product yields have been reported as typically twice and in some instances as much as ten times possible using conventional systems. Precursor usage is often just 10% of that required conventionally and for biomolecules has been reported as being as low as 1%.
  • Expandable – The NanoTek is capable of including in line tracer concentration and purification steps  to maximize RAC and add MS characterization
  • Integration – In line purification and compound characterization can be seamlessly undertaken.
  • Versatility –  Publications and applications to date have reported successful tracer synthesis using a variety of isotopes including 11C, 13N, 18F, 99mTc, 111In, 211At. In excess of 40 novel tracers have been produced using the system.  All possible using one configuration.
  • Extended synthesis capabilities – The reactor(s) can operate at pressures up to 400psi (28 Bar) and temperatures in excess of 200C enabling experiments to be conducted under conditions not possible with conventional vial based systems including microwave reactors.
  • Purification using Analytical HPLC  –  Reduced product volumes and reduced by product formation, a consequence of microflow chemistry combined with post synthesis concentration enables tracers to be purified using analytical HPLC columns reducing final product volumes to 1ml or less and optimizing RAC for preclinical studies.

NanoTek Success Stories

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Vanderbilt University, Institute of Imaging Science, Nashville, TN

"Establish in one day what traditionally takes weeks."

H. Charles Manning, Ph.D., Director of Molecular Imaging Research

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Recent NanoTek Publications

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NanoTek Application Notes

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Sequential Back-to-Back Preparation of Two Radiotracers from One Delivery of 18F

The NanoTek Microfluidic Synthesis System provides a flexible platform for offering dual benefits of high efficiency and fast synthesis. This application note describes how the NanoTek system can be configured for the sequential back-to-back preparation of two different radiotracers from one delivery of [18F]fluoride.

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