• Ion Source: ESI, APCI, or APCI/ASAP (direct analysis probe)
  • API interface: orthogonal ion sampling from heated capillary – allows for small single turbo pump (Patents pending)
  • Flow rate range: 10 µL/min to 1 mL/min ESI; 10 µL/min to 2 mL/min APCI
  • Polarity: Positive & Negative ion switching in single analysis
  • Polarity Switching Speed: 50 ms
  • m/z Range: -E model m/z 80 to m/z 800; -S model m/z 10 to m/z 1,200; -L model m/z 10 to m/z 2,000
  • Acquisition speed: 10,000 m/z units sec-1 (compatible with UHPLC)
  • Resolution: 0.5-0.7 m/z units (FWHM) at 1000 m/z units sec-1 over entire acquisition range
  • SIM sensitivity: 10 pg Reserpine (FIA – 5µL sample injection volume at 100 µL/min) 100:1 S/N (RMS) with SIM of m/z 609.28
  • Accuracy: ± 0.1 m/z units over entire acquisition range
  • Dynamic Range: 4.5 orders of magnitude

expression CMS Success Stories

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Cyclotron and Radiochemistry Research Program – UNC School of Medicine

“The convenience of having a mass spectrometer in our laboratory means that we can increase working efficiencies.”

Dr. Zibo Li, Department of Radiology UNC School of Medicine

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Department for Homogeneous Catalysis, Max-Planck-Institut für Kohlenforschung

“Rapid characterization of reaction products combined with the lowest effort of sample preparation”

List Research Group, Max-Planck-Institut für Kohlenforschung

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Center for Free-Electron Laser Science (CFEL), Hamburg, Germany

"We are able to follow the process of most of our reactions which greatly facilitates our research."

Dr. Marta Sans, Research group of Prof. Dr. Arwen Pearson

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Albert-Ludwigs-University, Freiburg, Germany

"We can now analyse highly air sensitive compounds without difficulty and outside a glove box."

Prof. Dr. Ingo Krossing, Institute for Inorganic and Analytical Chemistry

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Recent expression CMS Publications

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expression CMS Application Notes

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Screening of Dietary Supplements by ASAP® Compact Mass Spectrometry

In this application note, we demonstrate the use of the Advion expressionL CMS with an atmospheric solids analysis probe (ASAP) ion source to analyze two supplements (figure 1) that contain DMBA, a synthetic stimulant that has not been tested on humans. The substance is the chemical cousin to drug DBAA, which is currently banned by…

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Chemically Tracking Spoilage of Meat Using Vapor Mass Spectrometry

This application note demonstrates the use of the Advion expression CMS (compact mass spectrometer) coupled with a vapor APCI (vAPCI) ion source to directly detect several key chemicals given off of meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured  over several days as meat spoiled.

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Protein analysis via LC/CMS with automated charge state deconvolution

The Advion deconvolution algorithm employs a combination of predictive charge envelope generation, overlap calculation with actual MS data acquired utilizing a maximum entropy goodness of fit approach followed by artifact removal through determination of peak significance. This novel approach allows for a rapid deconvolution over a wide mass range in seconds. It also allows a…

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LC/MS Screening For EDTA In Fresh Blood Swabs Using the Advion expression CMS System

This application note suggests that a simple LC/MS screen of a relatively fresh sample of human whole blood collected from a lavender capped potassium EDTA anticoagulant blood sample applied to a cotton swab can be analyzed by full-scan positive ion or negative ion LC/MS using a compact single quadrupole mass spectrometer (expression CMS).

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