expression CMS

High performance compact mass spectrometer

The expression CMS provides essential information quickly and improves the chemist’s workflow. Modern organic labs have become automated; faster and more critical reactions require co-located versatile analytics — the expression CMS solves this at an affordable price.

"Our laboratory has recently purchased an Advion expression Compact Mass Spectrometer. Our choice was not only related to the small footprint but also to the versatility of the system. The Advion expression CMS provides the quality of results necessary to improve research outcomes in our hit and lead discovery efforts."

Tiago Rodrigues – ETH Zürich, Switzerland


Few laboratories analyze one type of sample or one technique all day, every day. Most require the ability to analyze a range of samples using more than one technique. This allows for a more complete identification and characterization of samples. The expression CMS integrates with nearly every chemistry technique.

  • Atmospheric Solids Analysis Probe (ASAP)
  • Thin-layer Chromatography (TLC by Plate Express)
  • 'Tides (peptide and other biomolecule analysis system)
  • Flow Injection
  • Flow Chemistry
  • Flash Chromatography
  • Preparative Liquid Chromatography (Prep-LC)
  • Supercritical Fluids Chromatography (SFC)

VIDEO: How to Perform Easy & Rapid Compound ID

"My recent initiative in providing and finding research funding has resulted in the purchase of the first Advion expression compact mass spectrometer to be installed in Australia in our research laboratory. This will improve the quality of the decision making process of my PG students in the research place leading to more efficient research outcomes and provide a mass spectral service to disciplines in our college at RMIT University." Helmut Hugel - RMIT University, Australia

expression CMS Success Stories

See more success stories »

Cyclotron and Radiochemistry Research Program – UNC School of Medicine

“The convenience of having a mass spectrometer in our laboratory means that we can increase working efficiencies.”

Dr. Zibo Li, Department of Radiology UNC School of Medicine

Read More »

Department for Homogeneous Catalysis, Max-Planck-Institut für Kohlenforschung

“Rapid characterization of reaction products combined with the lowest effort of sample preparation”

List Research Group, Max-Planck-Institut für Kohlenforschung

Read More »

Center for Free-Electron Laser Science (CFEL), Hamburg, Germany

"We are able to follow the process of most of our reactions which greatly facilitates our research."

Dr. Marta Sans, Research group of Prof. Dr. Arwen Pearson

Read More »

Albert-Ludwigs-University, Freiburg, Germany

"We can now analyse highly air sensitive compounds without difficulty and outside a glove box."

Prof. Dr. Ingo Krossing, Institute for Inorganic and Analytical Chemistry

Read More »

Recent expression CMS Publications

See more publications »

expression CMS Application Notes

See more application notes »

Screening of Dietary Supplements by ASAP® Compact Mass Spectrometry

In this application note, we demonstrate the use of the Advion expressionL CMS with an atmospheric solids analysis probe (ASAP) ion source to analyze two supplements (figure 1) that contain DMBA, a synthetic stimulant that has not been tested on humans. The substance is the chemical cousin to drug DBAA, which is currently banned by…

Read More »

Chemically Tracking Spoilage of Meat Using Vapor Mass Spectrometry

This application note demonstrates the use of the Advion expression CMS (compact mass spectrometer) coupled with a vapor APCI (vAPCI) ion source to directly detect several key chemicals given off of meat as it spoils at ambient temperature. Evolution of putrescine, cadaverine, and indole were measured  over several days as meat spoiled.

Read More »

Protein analysis via LC/CMS with automated charge state deconvolution

The Advion deconvolution algorithm employs a combination of predictive charge envelope generation, overlap calculation with actual MS data acquired utilizing a maximum entropy goodness of fit approach followed by artifact removal through determination of peak significance. This novel approach allows for a rapid deconvolution over a wide mass range in seconds. It also allows a…

Read More »

LC/MS Screening For EDTA In Fresh Blood Swabs Using the Advion expression CMS System

This application note suggests that a simple LC/MS screen of a relatively fresh sample of human whole blood collected from a lavender capped potassium EDTA anticoagulant blood sample applied to a cotton swab can be analyzed by full-scan positive ion or negative ion LC/MS using a compact single quadrupole mass spectrometer (expression CMS).

Read More »