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LESA - Liquid Extraction Surface Analysis

 

 

Combining the Ease and Speed of Direct Surface Analysis with the

Power and Soft Ionization of Chip-based Nanoelectrospray Mass Spectrometry

 

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Simultaneously identify drugs and their
phase I & II metabolites directly from tissue samples

The TriVersa NanoMate now has a sampling mode capable of extracting samples directly from a variety of surfaces for analysis by infusion through the high performance nanoelectrospray ESI Chip. This new mode of analysis is in addition to the already well-established methods of NanoMate operation: zero carry-over infusion, chip-based LC/MS, coupling and fraction collection.

 

Use the TriVersa NanoMate to sample directly from:                                               

  •    Thin tissue sections
  •    Dried blood spots on paper                                                                                      
  •    MALDI plates for complementary information by ESI
  •    TLC plates and other planar separation media

This technique has a wide range of applications for both small and large molecules.

PRODUCT NOTE

REFERENCES

Correlation of Skin Blanching and Percutaneous Absorption for Glucocorticoid Receptor Agonists by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Liquid Extraction Surface Analysis with Nanoelectrospray Ionization Mass Spectrometry

Marshall, P.; Toteu-Djomte, V.; Bareille, P.; Perry, H.; Brown, G.; Baumert, M.; Biggadike, K.

Anal. Chem. 2010 [Epub ahead of print]

Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform

Kertesz, V.; Van Berkel, G.J. J Mass Spectrom. 2009 Dec 17. [Epub ahead of print]

Journal Abstract

 

LESA Kit                      LESA

 

  LESA kit (software, custom solvent reservoirs,

  special sample plate, lightbox and TriVersa NanoMate)

               Surface sampling of thin tissue section                via LESA and the TriVersa NanoMate

A New Direction in Sample Analysis is Surfacing!

Register for a WEBINAR

LESA Route

LESA - Liquid Extraction
             Surface Analysis via
             TriVersa NanoMate

Click Here to Register

Presented by Thomas Covey, Principal Research Scientist

of AB SCIEX

Fast. Simple. Direct.

See more analytes with better sensitivity by combining LESA with mass spectrometry and chip-based nanoESI via Advion’s TriVersa NanoMate. Applications include sample analysis from a variety of surfaces e.g.

tissue slices, TLC plates, MALDI plates, and

Dried Blood Spots.

Click here for more information.